Browsing by Author "Álvarez Lobos, Manuel"
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- ItemColitis de Crohn: Resultados del tratamiento quirúrgico y evolución alejada(2018) Imigo Gueregat, Felipe Andrés; Molina Pezoa, María Elena; Álvarez Lobos, Manuel; Quintana Villar, Carlos; Klaassen Lobos, Julieta Isabel; Torres Montes, Paula Javiera; Duarte, Ignacio; Bellolio R., Felipe; Zúñiga Díaz, Alvaro
- ItemDo Patients Older Than 60 Years With Inflammatory Bowel Disease Have More Vertebral Fractures Than Age-matched Controls? A Study Using Abdominal and Pelvic CT Scans With Sagittal Reformatting as Screening Tool.(2020) Besa Vial, Pablo José; Meissner, Arturo; Ledermann, Gerardo; Pérez Valenzuela, Javier; Vergara López, María; Álvarez Lobos, Manuel; Urrutia Escobar, Julio OctavioIntroduction: Inflammatory bowel disease (IBD) has been associated with metabolic bone disease and increased fractures. This association is directly influenced by the disease and indirectly influenced by treatment. Therefore, patients with IBD could develop an elevated risk of osteoporotic fractures, particularly vertebral compression fractures (VCFs); however, symptomatic VCFs have not been shown to be more common in these patients. Our study evaluated the prevalence of VCF, independent of the presence of spinal symptoms, in IBD patients. Methods: We assessed IBD patients previously enrolled in a prospective cohort. All patients from that cohort who underwent computed tomography (CT) scans for nonspinal conditions were evaluated to detect the presence of VCFs. VCFs were classified using the Genant scheme. We evaluated whether patients with or without VCF differed in demographic data, type of IBD, treatment received and time from diagnosis. We used logistic regression to assess the independent effect of each variable. Results: In total, 6.5% of these patients had at least one VCF. Most fractures were Genant I (77%) and mostly at the thoracolumbar junction (T11 to L2, 65%). Bivariate and logistic regression analyses showed that age was the only variable independently associated with VCF (OR 1.12, 1.05 to 1.19). Conclusion: VCFs are not unusual in OBD patients. Radiologists and clinicians should specifically look for the presence of VCFs in patients with IBD, particularly the elderly, by using abdominal and pelvic CT scans.
- ItemEscherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome(2014) De La Fuente, M.; Franchi, L.; Araya, D.; Díaz Jimenez, D.; Olivares, M.; Álvarez Lobos, Manuel; Golenbock, D.; Gonzalez, M.
- ItemModulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance(2016) Riquelme Colet, Sebastián Alejandro; Carreno, L.; Espinoza Véliz, Janyra Alejandra; Mackern Oberti, Juan Pablo; Álvarez Lobos, Manuel; Riedel, C.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemPersistent salmonella enterica serovar typhimurium infection increases the susceptibility of mice to develop intestinal inflammation(2018) Schultz, B.; Salazar, G.; Paduro, C.; Pardo Roa, Catalina; Pizarro, D.; Salazar Echegarai, Francisco Javier; Torres Montes, Paula Javiera; Riedel, C.; Kalergis Parra, Alexis Mikes; Álvarez Lobos, Manuel; Bueno Ramírez, Susan
- ItemPredominance of Clostridium difficile ribotypes 012, 027 and 046 in a university hospital in Chile, 2012(2016) Plaza Garrido, Á.; Barra Carrasco, Jonathan Eduardo; Macías, J. H.; Carman, R.; Fawley, W. N.; Wilcox, M. H.; Hernández Rocha, Cristián Antonio; Guzmán Durán, Ana María; Álvarez Lobos, Manuel; Paredes Sabja, D.
- ItemProspective comparison of a commercial multiplex real-time polymerase chain reaction and an enzyme immunoassay with toxigenic culture in the diagnosis of Clostridium difficile-associated infections(2013) Hernández Rocha, Cristián Antonio; Barra Carrasco, Jonathan Eduardo; Álvarez Lobos, Manuel; Paredes Sabja, D.; Guzmán Durán, Ana María
- ItemRendimiento de índices pronósticos en infección asociada a Clostridium difficile grave. Análisis retrospectivo en un hospital universitario(2014) Hernández Rocha, Cristián Antonio; Tejos Sufan, Rodrigo; Plaza Garrido, Ángela; Barra Carrasco, Jonathan Eduardo; Agüero Luengo, Carlos; Inostroza Levy, Gonzalo; Ibáñez Lazo, Patricio Fernando; Guzmán Durán, Ana María; Álvarez Lobos, Manuel; Molina Pezoa, María Elena; Paredes Sabja, Daniel
- ItemRole of Salmonella enterica exposure in Chilean Crohn's disease patients(2013) Álvarez Lobos, Manuel; Pizarro, D.; Espinoza, A.; Sebastian, V.; Alvarado, J.; Ibáñez Lazo, Patricio Fernando; Quintana Villar, Carlos; Díaz Patiño, Orlando; Kalergis Parra, Alexis Mikes; Bueno Ramírez, Susan
- ItemThe absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice.(2019) Berkowitz Fiebich, Loni; Pardo Roa, Catalina; Ramírez Rojas, Gigliola; Vallejos Galvez, Omar Patricio; Sebastián Quijada, Valentina Pilar; Riedel, Claudia A.; Álvarez Lobos, Manuel; Bueno Ramírez, SusanPaneth cells (PCs) are specialized epithelial cells of the small bowel that contain multiple secretory granules filled with antimicrobial peptides and trophic factors, which are essential for the control of the microorganisms growth and maintaining intestinal integrity. Alterations in their function are associated with an imbalance of the normal microbiota, gastrointestinal infections and inflammatory processes, such as Crohn's disease (CD). One of the most common murine models for studying CD is IL-10-/- mouse. IL-10-/- mice when housed in conventional conditions and take contact with commensal microorganisms develop an acute enterocolitis mediated by a Th1 immune response. Even though, alterations in PCs function are related to CD, they had not been characterized yet in this mouse model. Here we show that in specific pathogen free conditions IL-10-/- mice have aberrant granules and a large number of immature PCs at the bottom of the crypt in the ileum of IL-10-/- mice before developing intestinal inflammation, along with a reduced expression of Indian Hedgehog. In addition, IL-10-/- Paneth cells presented a reduced expression of cryptidin-4, and a heterogeneous distribution of lysozyme+ granules. The alterations in the maturation of the PCs at the bottom of the crypt were not modified after the colonization by the conventional microbiota. On the other hand, depletion of microbiota altered the phenotype, but did not normalize PCs. Our results suggest that IL-10 could be necessary for the integrity of PCs. Moreover, our results help to explain why IL-10-/- mice develop enterocolitis in response to microorganisms.