Browsing by Author "Alberti Reus, Gigliola Loredana"

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    Actualización en el manejo de pacientes con insuficiencia intestinal
    (2014) Alberti Reus, Gigliola Loredana; Le Roy Olivos, Catalina María; Cofré Dougnac, Colomba Del Carmen; Pattillo Silva, Juan Carlos; Domínguez Bustamante, María del Pilar; Guerra Castro, Juan Francisco
    Intestinal failure is defined as the reduction of a functional gut mass below the minimal necessary for adequate digestion and absorption of nutrients and fluids. Intestinal failure is the final result of a number of different causes, being short bowel syndrome the most recognized. Its prevalence is low, but the impact in quality of life among patients and their families is critical. Furthermore, is associated with high economic costs, both for the patient and the health provider. Its main feature is the need for long-term parenteral nutritional support with high morbidity and mortality associated complications, such as line-derived bloodstream infections and liver disease. The management of these patients should be performed by a multidisciplinary team, and be aimed at promoting adaptation and recovery of bowel function to achieve intestinal autonomy.
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    Copy number polymorphism of the salivary amylase gene: Implications in human nutrition research
    (2012) Santos Martín, José Luis; Saus, E.; Smalley Meylan, Susan Valerie; Cataldo Bascuñan, Luis Rodrigo; Alberti Reus, Gigliola Loredana; Parada, J.; Gratacòs, M.; Estivill, X.
    The salivary alpha-amylase is a calcium-binding enzyme that initiates starch digestion in the oral cavity. The alpha-amylase genes are located in a cluster on the chromosome that includes salivary amylase genes (AMY1), two pancreatic alpha-amylase genes (AMY2A and AMY2B) and a related pseudogene. The AMY1 genes show extensive copy number variation which is directly proportional to the salivary alpha-amylase content in saliva. The alpha-amylase amount in saliva is also influenced by other factors, such as hydration status, psychosocial stress level, and short-term dietary habits. It has been shown that the average copy number of AMY1 gene is higher in populations that evolved under high-starch diets versus low-starch diets, reflecting an intense positive selection imposed by diet on amylase copy number during evolution. In this context, a number of different aspects can be considered in evaluating the possible impact of copy number variation of the AMY1 gene on nutrition research, such as issues related to human diet gene evolution, action on starch digestion, effect on glycemic response after starch consumption, modulation of the action of alpha-amylases inhibitors, effect on taste perception and satiety, influence on psychosocial stress and relation to oral health. Copyright (C) 2012 S. Karger AG, Basel
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    Prevalence of Fatty Pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study
    (Elsevier Editora Ltda, 2024) Alberti Reus, Gigliola Loredana; Cantillo Rocha, Thelma De Jesús; Pereira, Ana; De Barbieri Magnone, Florencia Beatriz; Garcia Bruce, Cristian Jorge; Dinamarca Villarroel, Luis Antonio; Gana Ansaldo, Juan Cristobal
    Objective: Nonalcoholic Fatty Pancreas Disease (NAFPD) is characterized by excessive lipid accumulation within the pancreas in the absence of alcohol intake, potentially leading to pancreatic dysfunction and metabolic complications, including type 2 diabetes mellitus, acute and chronic pancreatitis, and pancreatic carcinoma. The authors aim to estimate the prevalence of NAFPD and its association with anthropometric parameters in a cohort of Chilean adolescents. Method: The authors conducted a cross-sectional analysis of the "Growth and Obesity Chilean Cohort Study" (GOCS), a longitudinal study involving nearly 1000 children, followed yearly since 2006. All participants underwent anthropometric measurements and abdominal ultrasonography. Results: A total of 741 adolescents were included; 30 exhibited ultrasonography findings compatible with fatty pancreas (4 %). Adolescents with NAFPD had higher BMI z-score (2.33 (1.52–2.69) vs 0.67 (-0.2–1.4), p < 0.001), waist circumference (WC) (90.9 (81.53–98.58) vs 72.2 (67.55–79.83), p < 0.001), waist-to-height ratio (0.55 (0.48–0.6) vs 0.44 (0.41–0.49), p < 0.001), triponderal index (17.35 (15.14–19.25) vs 13.62 (12.07–15.54), p < 0.001), subcutaneous fat (32.4 (21.77–44.95) vs 16.2 (9.3 - 25.3), p < 0.001), visceral fat (45.15 (36.92–62.08) vs 35.5 (28.55–44.25), p < 0.001), systolic blood pressure (p = 0.009), and diastolic blood pressure but only in boys (p = 0.004) compared with controls. The prevalence of liver steatosis was significantly higher in the NAFPD group (63.3% vs 5.2 %, p < 0.001). After adjusting for sex and BMI, only the association with waist circumference and liver steatosis remains statistically significant. Conclusion: In adolescents, NAFPD has a prevalence of 4 % and is associated with a higher BMI z-score, WC, superficial fat, and blood pressure levels. Liver steatosis exhibited a strong association with NAFPD.