Browsing by Author "Alcorta, Jaime"

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    High-Quality Draft Genome Sequence of the Siderophilic and Thermophilic Leptolyngbyaceae Cyanobacterium JSC-12
    (2021) Brown, Igor; Tringe, Susannah G.; Ivanova, Natalia; Goodwin, Lynne; Shapiro, Nicole; Alcorta, Jaime; Pan, Donald; Chistoserdov, Andrei; Sarkisova, Svetlana; Woyke, Tanja
    The siderophilic, thermophilic Leptolyngbyaceae cyanobacterium JSC-12 was isolated from a microbial mat in an iron-depositing hot spring. Here, we report the high-quality draft genome sequence of JSC-12, which may help elucidate the mechanisms of resistance to extreme iron concentrations in siderophilic cyanobacteria and lead to new remediation biotechnologies.
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    Rickettsia felis DNA recovered from a child who lived in southern Africa 2000 years ago
    (2023) Rifkin, Riaan F. F.; Vikram, Surendra; Alcorta, Jaime; Ramond, Jean-Baptiste; Cowan, Don A. A.; Jakobsson, Mattias; Schlebusch, Carina M. M.; Lombard, Marlize
    The Stone Age record of South Africa provides some of the earliest evidence for the biological and cultural origins of Homo sapiens. While there is extensive genomic evidence for the selection of polymorphisms in response to pathogen-pressure in sub-Saharan Africa, e.g., the sickle cell trait which provides protection against malaria, there is inadequate direct human genomic evidence for ancient human-pathogen infection in the region. Here, we analysed shotgun metagenome libraries derived from the sequencing of a Later Stone Age hunter-gatherer child who lived near Ballito Bay, South Africa, c. 2000 years ago. This resulted in the identification of ancient DNA sequence reads homologous to Rickettsia felis, the causative agent of typhus-like flea-borne rickettsioses, and the reconstruction of an ancient R. felis genome.