Browsing by Author "Arrazola Tello, Macarena Soledad."
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- ItemCalcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway(2009) Arrazola Tello, Macarena Soledad.; Varela Nallar, Lorena Patricia; Colombres Raby, Marcela.; Inestrosa Cantín, Nibaldo
- ItemCanonical Wnt signaling protects hippocampal neurons from A beta oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics(2013) Silva Alvarez, Carmen.; Arrazola Tello, Macarena Soledad.; Godoy Zeballos, Juan Alejandro; Inestrosa Cantín, Nibaldo
- ItemIs L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice(2015) Tapia Rojas, Cheril Cecilia; Lindsay, Carolina B.; Montecinos Oliva, Carla; Arrazola Tello, Macarena Soledad.; Retamales, Rocio M.; Inestrosa Cantín, Nibaldo; Bunout, Daniel; Hirsch, Sandra.Abstract Background L-methionine, the principal sulfur-containing amino acid in proteins, plays critical roles in cell physiology as an antioxidant and in the breakdown of fats and heavy metals. Previous studies suggesting the use of L-methionine as a treatment for depression and other diseases indicate that it might also improve memory and propose a role in brain function. However, some evidence indicates that an excess of methionine can be harmful and can increase the risk of developing Type-2 diabetes, heart diseases, certain types of cancer, brain alterations such as schizophrenia, and memory impairment. Results Here, we report the effects of an L-methionine-enriched diet in wild-type mice and emphasize changes in brain structure and function. The animals in our studypresented 1) higher levels of phosphorylated tau protein, 2) increased levels of amyloid-β (Aβ)-peptides, including the formation of Aβ oligomers, 3) increased levels of inflammatory response,4) increased oxidative stress, 5) decreased level of synaptic proteins, and 6) memory impairment and loss. We also observed dysfunction of the Wnt signaling pathway. Conclusion Taken together, the results of our study indicate that an L-methionine-enriched diet causes neurotoxic effects in vivo and might contribute to the appearance of Alzheimer’s-like neurodegeneration.
- ItemWASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by A beta oligomers(2015) Vargas Galarce, Jessica Yelena; Arrazola Tello, Macarena Soledad.; Inestrosa Cantín, Nibaldo
- ItemWnt-5a Ligand Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons(2014) Godoy Zeballos, Juan Alejandro; Arrazola Tello, Macarena Soledad.; Inestrosa Cantín, Nibaldo