Browsing by Author "Brito, Ivan"

Now showing 1 - 6 of 6
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    A Family of Ir(III) Complexes with High Nonlinear Optical Response and Their Potential Use in Light-Emitting Devices
    (2015) Loeb Luschow, Bárbara; Gonzalez, Ivan A.; Cortes Arriagada, Diego; Dreyse, Paulina A.; Caramori, Stefano; Ledoux Rak, Isabelle; Andrade, Daniel; Brito, Ivan; Soto Arriaza, Marco; Toro Labbé, Alejandro; Sanhueza Vega, Luis
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    Crystal structure of 4-chloro-2-methyl-6-(4-(trifluoromethoxy)phenyl)pyrimidine, c12h8clf3n2o
    (2018) Bertrand, Jean-Luc; Salas, Cristian O.; Brito, Ivan
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    High Performance of Mn2O3 Electrodes for Hydrogen Evolution Using Natural Bischofite Salt from Atacama Desert: A Novel Application for Solar Saline Water Splitting
    (2024) Galleguillos-Madrid, Felipe M.; Salazar-Avalos, Sebastian; Fuentealba, Edward; Leiva-Guajardo, Susana; Caceres, Luis; Portillo, Carlos; Sepulveda, Felipe; Brito, Ivan; Cobos-Murcia, Jose Angel; Rojas-Moreno, Omar F.; Jimenez-Arevalo, Victor; Schott, Eduardo; Soliz, Alvaro
    Solar saline water splitting is a promising approach to sustainable hydrogen production, harnessing abundant solar energy and the availability of brine resources, especially in the Atacama Desert. Bischofite salt (MgCl26H2O) has garnered significant attention due to its wide range of industrial applications. Efficient hydrogen production in arid or hyper arid locations using bischofite solutions is a novel and revolutionary idea. This work studied the electrochemical performance of Mn2O3 electrodes using a superposition model based on mixed potential theory and evaluated the superficial performance of this electrode in contact with a 0.5 M bischofite salt solution focusing on the hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) that occur during saline water splitting. The application of the non-linear superposition model provides valuable electrochemical kinetic parameters that complement the understanding of Mn2O3, this being one of the novelties of this work.
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    Novel Hydrophobic Functionalized UiO-66 Series: Synthesis, Characterization, and Evaluation of Their Structural and Physical-Chemical Properties
    (2024) Narea, Pilar; Brito, Ivan; Quintero, Yurieth; Camu, Esteban
    A novel set of four functionalized hydrophobic UiO-66-NHR series were synthesized through postsynthetic procedures, utilizing various benzoyl chlorides and UiO-66-NH2 as starting materials. This synthesis method was carried out by employing p- (1) and o-toluoyl (2), as well as 2- (3) and 4-fluorobenzoyl (4) substituents. The analysis of the resulting compounds was performed using conventional spectroscopic methods such as FT-IR and 1H NMR to quantify the conversion rate into amide. Furthermore, SEM and XPS techniques were employed for morphological and surface analysis. Finally, the evaluation of the chemical stability and contact angle using the sessile drop method was performed to evaluate the technological potential of these compounds for application in aqueous and acidic media (such as selective separation of different metals and wastewater recovery).
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    Phenoxy- and Phenylamino-Heterocyclic Quinones: Synthesis and Preliminary Anti-Pancreatic Cancer Activity
    (WILEY-V C H VERLAG GMBH, 2022) Sanchez, Patricio; Salas, Cristian O.; Gallardo-Fuentes, Sebastian; Villegas, Alondra; Veloso, Nicolas; Honores, Jessica; Inman, Martyn; Isaacs, Mauricio; Contreras, Renato; Moody, Christopher J.; Cisterna, Jonathan; Brito, Ivan; Tapia, Ricardo A.
    The successful application of fragment-based drug discovery strategy for the efficient synthesis of phenoxy- or phenylamino-2-phenyl-benzofuran, -benzoxazole and -benzothiazole quinones is described. Interestingly, in the final step of the synthesis of the target compounds, unusual results were observed on the regiochemistry of the reaction of bromoquinones with phenol and aniline. A theoretical study was carried out for better understanding the factors that control the regiochemistry of these reactions. The substituted heterocyclic quinones were evaluated in vitro to determine their cytotoxicity by the MTT method in three pancreatic cancer cell lines (MIA-PaCa-2, BxPC-3, and AsPC-1). Phenoxy benzothiazole quinone 26a showed potent cytotoxic activity against BxPC-3 cell lines, while phenylamino benzoxazole quinone 20 was the most potent on MIA-PaCa-2 cells. Finally, electrochemical properties of these quinones were determined to correlate with a potential mechanism of action. All these results, indicate that the phenoxy quinone fragment led to compounds with increased activity against pancreatic cancer cells.
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    (-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones
    (2018) Quinones, Natalia; Hernandez, Santiago; Espinoza Catalan, Luis; Villena, Joan; Brito, Ivan; Cabrera Caballero, Alan Raúl; Salas, Cristian O.; Cuellar Fritis, Mauricio Alcides