Browsing by Author "Caeiro, Francisco"

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    Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
    (2022) Martin-Nares, Eduardo; Federico Baenas, Diego; Cuellar Gutierrez, Maria Carolina; Hernandez-Molina, Gabriela; Christian Ortiz, Alberto; Neira, Oscar; Gutierrez, Miguel A.; Calvo, Romina; Jose Saad, Emanuel; Elgueta Pinochet, Sergio; Gallo, Jesica; Herrera Moya, Alejandra; Mansilla Aravena, Bellanides Agustina; Crespo Espindola, Maria Elena; Cairoli, Ernesto; Maria Bertoli, Ana; Cordoba, Mercedes; Wurmann Kiblisky, Pamela; Basualdo Arancibia, Washington Javier; Badilla Pineiro, Maria Natalia; Andrea Gobbi, Carla; Ariel Berbotto, Guillermo; Pisoni, Cecilia N.; Juarez, Vicente; Ana Cosatti, Micaela; Aste, Nora Maria; Airoldi, Carla; Llanos, Carolina; Vergara Melian, Cristian Fabian; Erlij Opazo, Daniel; Goecke, Annelise; Pastenes Montano, Paula Andrea; Tate, Patricio; Pablo Pirola, Juan; Stange Nunez, Lilith; Burgos, Paula, I; Mezzano Robinson, Maria Veronica; Michalland, Susana H.; Silva Labra, Francisco; Labarca Solar, Cristian Humberto; Veronica Lencina, Maria; Izquierdo Loaiza, Jorge Hernan; Del Castillo Gil, David Julian; Caeiro, Francisco; Paira, Sergio
    Background/Objective Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts from Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, and association with sex, ethnicity, and serological markers in a large cohort of Latin American patients with IgG4-RD. Methods We performed a multicenter medical records review study including 184 Latin American IgG4-RD patients. We assigned patients to clinical phenotypes: group 1 (pancreato-hepato-biliary), group 2 (retroperitoneal/aortic), group 3 (head and neck-limited), group 4 (Mikulicz/systemic), and group 5 (undefined). We focused the analysis on how sex, ethnicity, and clinical phenotype may influence the clinical and serological presentation. Results The mean age was 50.8 +/- 15 years. Men and women were equally affected (52.2% vs 48.8%). Fifty-four patients (29.3%) were assigned to group 1, 21 (11.4%) to group 2, 57 (30.9%) to group 3, 32 (17.4%) to group 4, and 20 (10.8%) to group 5. Male sex was associated with biliary tract (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.36-8.26), kidney (OR, 3.4; 95% CI, 1.28-9.25), and retroperitoneal involvement (OR, 5.3; 95% CI, 1.45-20). Amerindian patients presented more frequently with atopy history and gallbladder involvement. Group 3 had a female predominance. Conclusions Latin American patients with IgG4-RD were younger, and men and women were equally affected compared with White and Asian cohorts. They belonged more commonly to group 1 and group 3. Retroperitoneal and aortic involvement was infrequent. Clinical and serological features differed according to sex, ethnicity, and clinical phenotype.
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    Factors predictive of serious infections over time in systemic lupus erythematosus patients: data from a multi-ethnic, multi-national, Latin American lupus cohort
    (2019) Pimentel-Quiroz, V. R.; Ugarte-Gil, M. F.; Harvey, G. B.; Wojdyla, D.; Pons-Estel, G. J.; Quintana, R.; Esposto, A.; Garcia, M. A.; Catoggio, L. J.; Cardiel, M. H.; Barile, L. A.; Amigo, M-C; Sato, E., I; Bonfa, E.; Borba, E.; Lavras Costallat, L. T.; Neira, O. J.; Massardo, L.; Guibert-Toledano, M.; Chacon-Diaz, R.; Alarcon, G. S.; Pons-Estel, B. A.; Soriano, Enrique R.; Ceballos Recalde, Maria Flavia; Velozo, Edson; Manni, Jorge A.; Grimaudo, Sebastian; Sarano, Judith; Maldonado-Cocco, Jose A.; Arriola, Maria S.; Gomez, Graciela; Ines Marcos, Ana; Carlos Marcos, Juan; Scherbarth, Hugo R.; Lopez, Jorge A.; Motta, Estela L.; Drenkard, Cristina; Gamron, Susana; Buliubasich, Sandra; Onetti, Laura; Caeiro, Francisco; Alvarellos, Alejandro; Saurit, Veronica; Gentiletti, Silvana; Quagliatto, Norberto; Gentiletti, Alberto A.; Machado, Daniel; Abdala, Marcelo; Palatnik, Simon; Berbotto, Guillermo A.; Battagliotti, Carlos A.; Souza, Alexandre Wagner S.; Bertolo, Manoel Barros; Coimbra, Ibsen Bellini; Tavares Brenol, Joao C.; Monticielo, Odirlei; Xavier, Ricardo; Cavalcanti, Fernando de Souza; Branco Duarte, Angela Luzia; Lopes Marques, Claudia Diniz; da Silva, Nilzio Antonio; de O e Silva, Ana Carolina; Pacheco, Tatiana Ferracine; Fernando Molina-Restrepo, Jose; Molina-Lopez, Javier; Vasquez, Gloria; Ramirez, Luis A.; Uribe, Oscar; Iglesias-Gamarra, Antonio; Iglesias-Rodriguez, Antonio; Egea-Bermejo, Eduardo; Guzman-Moreno, Renato A.; Restrepo-Suarez, Jose F.; Alberto Reyes-Llerena, Gil; Hernandez-Martinez, Alfredo; Jacobelli, Sergio; Guzman, Leonardo R.; Garcia-Kutzbach, Abraham; Castellanos, Claudia; Cajas, Erwin; Pascual-Ramos, Virginia; Silveira, Luis H.; Garcia De La Torre, Ignacio; Orozco-Barocio, Gerardo; Estrada-Contreras, Magali L.; Sauza del Pozo, Maria Josefina; Aranda Baca, Laura E.; Urenda Quezada, Adelfia; Huerta-Yanez, Guillermo F.; Acevedo-Vazquez, Eduardo M.; Luis Alfaro-Lozano, Jose; Cucho-Venegas, Jorge M.; Ines Segami, Maria; Chung, Cecilia P.; Alva-Linares, Magaly; Abadi, Isaac; Rangel, Neriza; Al Snih Al Snih, Soham; Esteva-Spinetti, Maria H.; Vivas, Jorge
    Aim The aim of this study was to identify factors predictive of serious infections over time in patients with systemic lupus erythematosus (SLE). Methods A multi-ethnic, multi-national Latin American SLE cohort was studied. Serious infection was defined as one that required hospitalization, occurred during a hospitalization or led to death. Potential predictors included were sociodemographic factors, clinical manifestations (per organ involved, lymphopenia and leukopenia, independently) and previous infections at baseline. Disease activity (SLEDAI), damage (SLICC/ACR Damage Index), non-serious infections, glucocorticoids, antimalarials (users and non-users), and immunosuppressive drugs use; the last six variables were examined as time-dependent covariates. Cox regression models were used to evaluate the predictors of serious infections using a backward elimination procedure. Univariable and multivariable analyses were performed. Results Of the 1243 patients included, 1116 (89.8%) were female. The median (interquartile range) age at diagnosis and follow-up time were 27 (20-37) years and 47.8 (17.9-68.6) months, respectively. The incidence rate of serious infections was 3.8 cases per 100 person-years. Antimalarial use (hazard ratio: 0.69; 95% confidence interval (CI): 0.48-0.99; p = 0.0440) was protective, while doses of prednisone >15 and <= 60 mg/day (hazard ratio: 4.18; 95 %CI: 1.69-10.31; p = 0.0019) and >60 mg/day (hazard ratio: 4.71; 95% CI: 1.35-16.49; p = 0.0153), use of methylprednisolone pulses (hazard ratio: 1.53; 95% CI: 1.10-2.13; p = 0.0124), increase in disease activity (hazard ratio: 1.03; 95% CI: 1.01-1.04; p = 0.0016) and damage accrual (hazard ratio: 1.22; 95% CI: 1.11-1.34; p < 0.0001) were predictive factors of serious infections. Conclusions Over time, prednisone doses higher than 15 mg/day, use of methylprednisolone pulses, increase in disease activity and damage accrual were predictive of infections, whereas antimalarial use was protective against them in SLE patients.
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    Performance of the 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease in a Latin American Cohort
    (2024) Martin-Nares, Eduardo; Hernandez-Molina, Gabriela; Baenas, Diego Federico; Delgado de la Mora, Jesus; Caeiro, Francisco; Wurmann Kiblisky, Pamela; Pimentel-Quiroz, Victor R.; Ascuna Valdivia, Valery; Faz-Munoz, David; Saad, Emanuel Jose; Cairoli, Ernesto; Elgueta Pinochet, Sergio; Madariaga Charaja, Hugo; Montante-Montes de Oca, Daniel; Gallo, Jesica Romina; Ugarte-Gil, Manuel F.; Neira, Oscar; Burgos, Paula I.; Paira, Sergio
    Background/ObjectiveThe 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria (2019 AECC) for IgG4-related disease (IgG4-RD) is considered a significant advancement in the study of this condition. Most studies evaluating their performance have focused on White and Asian patients, leaving a knowledge gap regarding Latin American populations. Therefore, this study aimed to assess the performance of the 2019 AECC for IgG4-RD in a cohort of Latin American patients.MethodsA multicenter medical records review study was conducted, involving centers from Argentina, Chile, Mexico, Peru, and Uruguay. Data on IgG4-RD patients and mimicker conditions were collected through a standardized online form. The criterion standard for diagnosing IgG4-RD was based on the fulfillment of the Comprehensive Diagnostic Criteria for IgG4-RD and/or the Consensus Statement on Pathology. The 2019 AECC was retrospectively applied.ResultsWe included 300 patients, with 180 (60%) having IgG4-RD and 120 (40%) having mimicker conditions. The 2019 AECC had a sensitivity of 66.7% and a specificity of 100%. Sensitivity increased to 73.3% when disease-specific autoantibody items were removed, without affecting specificity. The true-positive cases had more involved organs, a higher availability of biopsy results, and were more likely to belong to the Mikulicz/systemic and proliferative phenotypes.ConclusionsThe use of the 2019 AECC for IgG4-RD in a Latin American population confirms its high specificity in excluding those without the disease. The presence of concomitant autoimmune diseases and clinically nonsignificant disease-specific autoantibodies excludes a significant number of patients from fulfilling the criteria.
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    Primary cardiac disease in systemic lupus erythematosus patients : protective and risk factors-data from a multi-ethnic Latin American cohort
    (2014) García, Mercedes A.; Alarcón, Graciela S.; Boggio, Gabriela; Hachuel, Leticia; Marcos, Ana Inés; Marcos, Juan Carlos; Gentilett, Silvana; Caeiro, Francisco; Sato, Emilia I.; Massardo Vega, Loreto