Browsing by Author "Carmona, Thais"

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    Functionalization using biocompatible carboxylated cyclodextrins of iron-based nanoMIL-100
    (2021) Carmona, Thais; Marco, Jose F.; Gimenez-Marques, Monica; Canon-Mancisidor, Walter; Gutierrez-Cutino, Marlen; Hermosilla-Ibanez, Patricio; Perez, Edwin G.; Minguez Espallargas, Guillermo; Venegas-Yazigi, Diego
    Here we report the first example of nanoMIL-100 particles modified with monomeric cyclodextrin derivatives of different length by exploiting strong interactions between non-saturated iron trimers at the external surface and carboxylate functionalities located at the end of biocompatible and flexible linkers of cyclodextrins. The main results revealed that, after the functionalization, the cyclodextrins are selectively located at the external surfaces covering the nanoparticles. Z potential measurements show that this functionalization induced changes respect to the bare nanoMIL-100 particles, however, the presence of the cyclodextrins does not modify the size neither porosity of the nanoparticles. The amount of cyclodextrins attached, investigated by thermogravimetry, increases with the length of the linker between CD cavity and nanoparticle surface, reaching up a 9 % wt. Auger spectroscopy suggested a clear predominant sp(3) character after the functionalizations (vs. sp(2) predominance in the unmodified nanoMIL-100). This study supposes the creation of an alternative family of hybrids based on carboxylated monomeric cyclodextrins.
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    The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions
    (2023) Salazar Muñoz, Javier Alonso; Carmona, Thais; Zacconi, Flavia C. M.; Venegas Yazigi, Diego; Cabello Verrugio, Claudio; Il Choi, Won; Vilos, Cristian
    Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, and its contribution to skin physiology is critical due to its diverse cellularity, vasculature, and release of molecular mediators involved in the extracellular matrix maintenance and modulation of the immune response. Skin structure and complexity limit the transport of substances, promoting the study of different types of nanoparticles that penetrate the skin layers under different mechanisms intended for skin illness treatments and dermo-cosmetic applications. In this work, we present a detailed morphological description of the dermis in terms of its structures and resident cells. Furthermore, we analyze the role of the dermis in regulating skin homeostasis and its alterations in pathophysiological conditions, highlighting its potential as a therapeutic target. Additionally, we describe the use of nanoparticles for skin illness treatments focused on dermis release and promote the use of metal-organic frameworks (MOFs) as an integrative strategy for skin treatments.