Browsing by Author "Carrasco, Rodrigo"

Now showing 1 - 4 of 4
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    S-Nitrosation of β-Catenin and p120 Catenin A Novel Regulatory Mechanism in Endothelial Hyperpermeability
    (2012) Marin, Natalie; Zamorano, Patricia; Carrasco, Rodrigo; Mujica, Patricio; Gonzalez, Francisco G.; Quezada, Claudia; Meininger, Cynthia J.; Boric, Mauricio P.; Duran, Walter N.; Sanchez, Fabiola A.
    Rationale: Endothelial adherens junction proteins constitute an important element in the control of microvascular permeability. Platelet-activating factor (PAF) increases permeability to macromolecules via translocation of endothelial nitric oxide synthase (eNOS) to cytosol and stimulation of eNOS-derived nitric oxide signaling cascade. The mechanisms by which nitric oxide signaling regulates permeability at adherens junctions are still incompletely understood.
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    S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability
    (2016) Guequén, Anita; Carrasco, Rodrigo; Zamorano, Patricia; Rebolledo, Lorena; Burboa, Pía; Sarmiento, José; Boric P., Mauricio; Korayem, Adam; Durán, Walter N.; Sánchez, Fabiola A.
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    Seminal plasma nerve growth factor signaling on the reproductive physiology of female llamas
    (BRAZILIAN COLL ANIMAL REPRODUCTION, 2022) Paiva, Luis; Silva, Mauricio; Carrasco, Rodrigo; Ratto, Vicente; Goicochea, Jose; Ratto, Marcelo
    The ovulation mechanism is one of the fascinating physiological processes in reproductive biology in mammals. From the reproductive point of view, the species have been classified as spontaneous or induced ovulators. Although the release of GnRH followed by the preovulatory LH surge is shared between both types of ovulation, the stimulus to initiate GnRH release varies between both categories. In spontaneous ovulators, ovulation depends on the systemic concentration of ovarian steroids, however, in induced ovulators, different stimuli such as copulation, environmental, and social cues can facilitate or induce ovulation regardless of the increases in systemic estradiol concentration. In this review, we document evidence that a male-derived protein is the main factor responsible for inducing ovulation and also modulating the ovarian function in the domestic South American camelid, the llama. The neurotrophin beta-Nerve Growth Factor (beta-NGF) is the principal factor present in the semen of llamas responsible for inducing ovulation in this species. After the intrauterine deposit of semen during mating, beta-NGF is absorbed through the endometrium to reach the circulatory system, where it reaches the hypothalamus and stimulates GnRH release. The potential site of action of this neurotrophin at the brain has not been elucidated, however, hypotheses are raised that the factor may cross the blood-brain barrier and stimulate upstream neuronal networks that lead to the stimulation of GnRH-secreting neurons. It is possible that beta-NGF could be sensed at the median eminence without crossing the blood-brain barrier. Finally, it has been observed that this factor is not only a powerful stimulator of ovulation but also has a luteotrophic effect, resulting in the development of a corpus luteum capable of secreting more progesterone when compared to other ovulation-stimulating analogues.
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    The ovulatory and luteotropic actions of the male-derived beta-nerve growth factor in South American camelids
    (OXFORD UNIV PRESS INC, 2022) Paiva, Luis; Silva, Mauricio; Carrasco, Rodrigo; Hector Ratto, Marcelo