Browsing by Author "Castillo, L"

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    Intra-arterial thrombolysis in locked-in syndrome. Report of two cases
    (SOC MEDICA SANTIAGO, 2004) Mellado, P; Sandoval, P; Tevah, J; Huete, I; Castillo, L
    Locked-in syndrome is a dramatic clinical condition, the patient is can listen. and breath, but is unable to move any muscle, conserving only The vertical eye movements. The most common cause of locked-in syndrome is the thrombosis of the basilar artery and commonly leads to death, frequently due to pneumonia. Intravenous and intra arterial thrombolysis have been used successfully in a selective group of patients with ischemic stroke. There is only one report of two patients with locked-in syndrome who were treated successfuly with intra arterial thrombolysis. Other authors, based in their experiences, do not recommended this treatment. We report two female patients aged 63 and 26 years, with Locked-in syndrome due to a basilar thrombosis who were treated successfully with intra arterial thrombolysis using ecombinant tissue plasminogen activator (r-TPA). The lapses between the onset of the symptoms and thrombolysis were 5 and 8 hours respectively. A complete recanalization was obtained in both patients during the thrombolysis. One year after, the first patient has only a moderate ataxia, walking with assistance and the other has a normal neurological examination (Rev Med Chile 2004; 132: 357-60).
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    Management of septic shock with a norepinephrine-based haemodynamic algorithm
    (ELSEVIER IRELAND LTD, 2005) Hernandez, G; Bruhn, A; Romero, C; Larrondo, FJ; De La Fuente, R; Castillo, L; Bugedo, G
    Management of septic shock (SS) with a norepinephrine (noradrenaline)-based haemodynamic algorithm. Introduction: The choice of the best vasopressor for haemodynamic management of septic shock is controversial. Nevertheless, very few studies have been focused on evaluating different management algorithms. The aim of this study was to evaluate the performance of a norepinephrine (NE)-based management protocol. Experience with NE as the initial vasopressor, even if not comparative, could bring relevant data for planning future trails. We also wanted to evaluate the compliance of critical care physicians and nurses with haemodynamic management protocol.
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    Use of methylene blue in patients with refractory septic shock: Impact on hemodynamics and gas exchange
    (W B SAUNDERS CO, 1998) Andresen, M; Dougnac, A; Diaz, O; Hernandez, G; Castillo, L; Bugedo, G; Alvarez, M; Dagnino, J
    Purpose: The purpose of this study was to assess the acute effects of methylene blue, an inhibitor of nitric oxide synthesis, on hemodynamics and gas exchange in patients with refractory septic shock in a prospective clinical trial at medical and surgical intensive care units in a tertiary university hospital.