Browsing by Author "Castro, J."
Now showing 1 - 9 of 9
Results Per Page
Sort Options
- ItemCaracterísticas e impacto de la sedación, la analgesia y el bloqueo neuromuscular en los pacientes críticos que recibieron ventilación mecánica prolongada(2009) Tobar, E.; Bugedo Tarraza, Guillermo; Andresen Hernández, Max; Aguirre, M.; Lira, M. T.; Godoy, J.; González, H.; Hernández, A.; Tomicic, V.; Castro, J.; Jara, J.; Ugarte, H.
- ItemCOVID-19 L·OVE REPOSITORY IS HIGHLY COMPREHENSIVE AND CAN BE USED AS A SINGLE SOURCE FOR COVID-19 STUDIES(2021) Verdugo Paiva, Francisca; Vergara, C.; Ávila, Camila; Castro, J.; Cid, J.; Contreras, V.; Jara, I.; Jiménez, Valentina; Ha Lee, Min; Muñoz, Magdalena; Rojas Gómez, Ana María; Roson Rodríguez, P.; Serrano Arevalo, K.; Silva Ruz, Ivan; Vásquez Laval, J.; Zambrano Achig, Paula; Zavadzki, Giovanna; Rada G., GabrielObjective: COVID-19 Living OVerview of Evidence (COVID-19 L·OVE) is a public repository and classification platform for COVID-19 articles. The repository contains over 430,000 articles as of 20 September 2021 and intends to provide a one-stop shop for COVID-19 evidence. Considering that systematic reviews conduct high-quality searches, this study assesses the comprehensiveness and currency of the repository against the total number of studies in a representative sample of COVID-19 systematic reviews. Methods: Our sample was generated from all the studies included in the systematic reviews of COVID-19 published during April 2021. We estimated the comprehensiveness of COVID-19 L·OVE repository by determining how many of the individual studies in the sample were included in the COVID-19 L·OVE repository. We estimated the currency as the percentage of studies that were available in the COVID-19 L·OVE repository at the time the systematic reviews conducted their own search. Results: We identified 83 eligible systematic reviews that included 2132 studies. COVID-19 L·OVE had an overall comprehensiveness of 99.67% (2125/2132). The overall currency of the repository, that is, the proportion of articles that would have been obtained if the search of the reviews was conducted in COVID-19 L·OVE instead of searching the original sources, was 96.48% (2057/2132). Both the comprehensiveness and the currency were 100% for randomised trials (82/82). Conclusion: The COVID-19 L·OVE repository is highly comprehensive and current. Using this repository instead of traditional manual searches in multiple databases can save a great amount of work to people conducting systematic reviews and would improve the comprehensiveness and timeliness of evidence syntheses. This tool is particularly important for supporting living evidence synthesis processes.
- ItemElectrodes based on zeolites modified with cobalt and/or molybdenum for pesticide degradation : part II—2,4,6-trichlorophenol degradation(2020) Castro, J.; Fernández, F.; Olivares, F.; Berríos, C.; Garrido-Ramírez, E.; Blanco, E.; Escalona, Néstor; Aspée, A.; Barrías, P.; Ureta-Zañartu, M. S.
- ItemGrowth, yield and iron deficiency tolerance level of six peach rootstocks grown on calcareous soil(2014) Sotomayor Sercka, Carlos; Ruiz S., Rafael; Castro, J.
- ItemHIV Testing Among Heterosexual Hispanic Women in South Florida(2019) Cianelli A., Rosina; Villegas, N.; Irarrázabal Vargas, Lisette Paola; Castro, J.; Ojukwu, E.N.; Adebayo, O.W.; Ferrer Lagunas, Lilian Marcela; Montano, N.P.
- ItemMassive volume fly-ash concrete : a more sustainable material with fly ash replacing cement and aggregates(2015) Rivera, F.; Martinez, P.; Castro, J.; López Casanova, Mauricio Alejandro
- ItemMilrinone as a Rescue Therapy for Symptomatic Refractory Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage(2009) Romero, C. M.; Morales, D.; Reccius, A.; Mena, F.; Prieto, J.; Bustos, P.; Larrondo, J.; Castro, J.Delayed ischemic neurological deficit associated to cerebral vasospasm is the most common cause of sequelae and death that follows the rupture of an aneurysm. The objective of this study was to evaluate the safety and efficacy of intra-arterial Milrinone in patients with symptomatic refractory cerebral vasospasm.
- ItemMLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content.(2017) Balboa Castillo, Elisa Ivana; Castro, J.; Cancino, G. I.; Matias, N.; Saez P., Jose; Martinez, A.; Álvarez Rojas, Alejandra; Garcia Ruiz, C.; Fernandez Checa, J. C.; Zanlungo Matsuhiro, Silvana; Pinochet, M.
- ItemThe implementation of an analgesia-based sedation protocol reduced deep sedation and proved to be safe and feasible in patients on mechanical ventilation(2013) Bugedo Tarraza, Guillermo; Tobar, E.; Aguirre, M.; Gonzalez, H.; Godoy, J.; Lira, M. T.; Lora, P.; Encalada, E.; Hernandez, A.; Tomicic, V.; Castro, J.; Jara, J.; Andresen Hernández, Max; Ugarte, H.INTRODUCTION: Deep sedation in critically ill patients is associated with a longer duration of mechanical ventilation and a prolonged length of stay in the intensive care unit. Several protocols have been used to improve these outcomes. We implement and evaluate an analgesia-based, goal-directed, nurse-driven sedation protocol used to treat critically ill patients who receive mechanical ventilation. METHODS: We performed a prospective, two-phase (before-after), non-randomized multicenter study that involved 13 intensive care units in Chile. After an observational phase (observational group, n=155), we designed, implemented and evaluated an analgesia-based, goal-directed, nurse-driven sedation protocol (intervention group, n=132) to treat patients who required mechanical ventilation for more than 48 hours. The primary outcome was to achieve ventilator-free days by day 28. RESULTS: The proportion of patients in deep sedation or in a coma decreased from 55.2% to 44.0% in the interventional group. Agitation did not change between the periods and remained approximately 7%. Ventilator-free days to day 28, length of stay in the intensive care unit and mortality were similar in both groups. At one year, post-traumatic stress disorder symptoms in survivors were similar in both groups. CONCLUSIONS: We designed and implemented an analgesia-based, goal-directed, nurse-driven sedation protocol in Chile. Although there was no improvement in major outcomes, we observed that the present protocol was safe and feasible and that it resulted in decreased periods of deep sedation without increasing agitation.INTRODUCTION: Deep sedation in critically ill patients is associated with a longer duration of mechanical ventilation and a prolonged length of stay in the intensive care unit. Several protocols have been used to improve these outcomes. We implement and evaluate an analgesia-based, goal-directed, nurse-driven sedation protocol used to treat critically ill patients who receive mechanical ventilation. METHODS: We performed a prospective, two-phase (before-after), non-randomized multicenter study that involved 13 intensive care units in Chile. After an observational phase (observational group, n=155), we designed, implemented and evaluated an analgesia-based, goal-directed, nurse-driven sedation protocol (intervention group, n=132) to treat patients who required mechanical ventilation for more than 48 hours. The primary outcome was to achieve ventilator-free days by day 28. RESULTS: The proportion of patients in deep sedation or in a coma decreased from 55.2% to 44.0% in the interventional group. Agitation did not change between the periods and remained approximately 7%. Ventilator-free days to day 28, length of stay in the intensive care unit and mortality were similar in both groups. At one year, post-traumatic stress disorder symptoms in survivors were similar in both groups. CONCLUSIONS: We designed and implemented an analgesia-based, goal-directed, nurse-driven sedation protocol in Chile. Although there was no improvement in major outcomes, we observed that the present protocol was safe and feasible and that it resulted in decreased periods of deep sedation without increasing agitation.