Browsing by Author "Celis, M."

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    Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America : The ESTAMPA screening study protocol
    (2020) Almonte, M.; Murillo, R.; Sánchez, G. I.; González, P.; Ferrera, A.; Picconi, M. A.; Wiesner, C.; Cruz Valdez, A.; Lazcano Ponce, E.; Ferreccio Readi, Catterina; Jerónimo, J.; Kasamatsu, E.; Mendoza, L.; Rodríguez, G.; Calderón, A.; Venegas, G.; Villagra, V.; Tatti, S.; Fleider, L.; Terán, C.; Baena, A.; Hernández, M. D. L. L.; Rol, M. L.; Lucas, E.; Barbier, S.; Ramírez, A. T.; Arrossi, S.; Rodríguez, M. I.; González, E.; Celis, M.; Martínez, S.; Salgado, Y.; Ortega, M.; Beracochea, A. V.; Pérez, N.; Rodríguez De La Peña, M.; Ramón, M.; Hernández Nevarez, P.; Arboleda Naranjo, M.; Cabrera, Y.; Salgado, B.; García, L.; Retana, M. A.; Colucci, M. C.; Arias Stella, J.; Bellido Fuentes, Y.; Bobadilla, M. L.; Olmedo, G.; Brito García, I.; Méndez Herrera, A.; Cardinal, L.; Flores, B.; Peñaranda, J.; Martínez Better, J.; Soilán, A.; Figueroa, J.; Caserta, B.; Sosa, C.; Moreno, A.; Mural, J.; Doimi, F.; Giménez, D.; Rodríguez, H.; Lora, O.; Luciani, S.; Broutet, N.; Darragh, T.; Herrero, R.
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    The identification of two subgroups of obese women with differing endometrial proliferation levels: potential consequences in the development of endometrial cancer
    (2012) Villavicencio, A.; Aguilar, G.; Acuna, J.; Gabler, F.; Soto, E.; Gaete, F.; Penaloza, P.; Celis, M.; Owen, G. I.
    Enhanced endometrial proliferation correlates obesity to type-I (estrogen-dependent) endometrial cancer (EC). Our aim was to distinguish obese women (without EC) with differing endometrial proliferation. Endometrial and blood samples were obtained from normal-weight and obese women without EC. Type-I EC samples were obtained from obese patients. On measuring endometrial proliferation (Ki67 and phosphorylated histone H3 (p-H3)), two groups of obese women without EC were identified: obese(High Proliferating) (O-HP) and obese(Low Proliferating) (O-LP). Increased Ki67 (88.5%, P<0.001), p-H3 (62.6%, P<0.01), 17 beta-estradiol/progesterone ratio (46.3%, P<0.01) and endometrial estrogen receptor alpha (ER alpha) (82.2%, P<0.001) were observed in O-HP compared with O-LP patients. ECs possessed similar ER alpha and enhanced proliferation as O-HP, suggesting that O-HP women are at higher risk of type-I EC. O-LP women were indistinguishable from normal-weight women regarding these determinants of endometrial proliferation, ER alpha and 17 beta-estradiol/progesterone ratio. Our data may further define the obesity phenotype in regards to type-I EC risk and may help identify obese women more susceptible to develop type-I EC, allowing early intervention and a potential reduction in mortality.