Browsing by Author "Cisternas, M"

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    Cardiovascular risk factors in Chilean patients with rheumatoid arthritis
    (J RHEUMATOL PUBL CO, 2002) Cisternas, M; Gutierrez, MA; Klaassen, J; Acosta, AM; Jacobelli, S
    Objective. Epidemiologic studies have shown an increased mortality rate in patients with rheumatoid arthritis (RA). The most common cause of death in these patients is cardiovascular disease. We estimated the frequency of and examined risk factors for coronary artery disease in Chilean patients with RA.
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    Catastrophic antiphospholipid syndrome associated with crescentic glomerulonephritis
    (2000) Cisternas, M; Gutiérrez, MA; Rosenberg, H; Jara, A; Jacobelli, S
    The association of renal failure with catastrophic antiphospholipid syndrome has been reported in the context of microvascular occlusions and/or malignant hypertension. We describe a 36-year-old woman who died of multiorgan failure with the laboratory, clinical and histopathological characteristics of catastrophic antiphospholipid syndrome associated with a crescentic glomerulonephritis and renal failure.
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    Clinical features of Wegener granulomatosis and microscopic polyangiitis in Chilean patients
    (SOC MEDICA SANTIAGO, 2005) Cisternas, M; Soto, L; Jacobelli, S; Marinovic, MA; Vargas, A; Sobarzo, E; Saavedra, J; Chauan, K; Melendez, G; Foster, C; Pacheco, D; Wainstein, E; Sociedad Chilena de Reumatologia
    Background Systemic vasculitis are a group of heterogeneous diseases characterized by inflammation and necrosis of blood vessel walls. The etiology is not known, but geographic and environmental, factors are implicated. Aim: To describe the clinical features of microscopic polyangiitis (MPA) and Wegener's granulomatosis (WG) in a Chilean cohort of patients. Patients and methods: Retrospective review of the medical records of 123 patients with the diagnosis of systemic vasculitis (65 MPA and 58 WG), seen from 1990 to 2001. The diagnosis were made based on the American College of Rheumatology and Chapel Hill criteria. Results: The mean follow-up for MPA was 15 months (1-120) and for WG, 20 months (1-120). The median age (years) at diagnosis for MPA was 61 (19-82) and WG 50 (20-82). Gender distribution was similar in both groups (male: 68% and 57% respectively). The main clinical features in the MPA group were renal involvement (68%), peripheral nervous system involvement (57%), pulmonary hemorrhage (28%), and skin disease (32%). In the WG group were alveolar hemorrhage (62%), renal involvement (78%); paranasal sinus involvement (57%); and ocular disease (26%). In both, creatinine levels above 2.0 mg/dl were associated with a higher mortality (p < 0.01). ANCA by immunofluorescence was performed in 56 MPA patients (75% had pANCA, 4% had cANCA and 21% were ANCA negative) and in 55 WG patients (17%, had pANCA, 79% had cANCA and 4% were ANCA negative). Global mortality was 18% and 17% respectively, and the most causes of death were infections. Conclusions: The clinical features of our patients are similar to other-published data. In our WG and MPA patients the main predictor for death was a serum creatinine above 2 mg/dl.
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    Predecessors of the giant 1960 Chile earthquake
    (2005) Cisternas, M; Atwater, BF; Torrejón, F; Sawai, Y; Machuca, G; Lagos, M; Eipert, A; Youlton, C; Salgado, I; Kamataki, T; Shishikura, M; Rajendran, CP; Malik, JK; Rizal, Y; Husni, M
    It is commonly thought that the longer the time since last earthquake, the larger the next earthquake's slip will be. But this logical predictor of earthquake size(1), unsuccessful for large earthquakes on a strike-slip fault(2), fails also with the giant 1960 Chile earthquake of magnitude 9.5 (ref. 3). Although the time since the preceding earthquake spanned 123 years (refs 4, 5), the estimated slip in 1960, which occurred on a fault between the Nazca and South American tectonic plates, equalled 250 - 350 years' worth of the plate motion(3,6-10). Thus the average interval between such giant earthquakes on this fault should span several centuries(3,9,10). Here we present evidence that such long intervals were indeed typical of the last two millennia. We use buried soils and sand layers as records of tectonic subsidence and tsunami inundation at an estuary midway along the 1960 rupture. In these records, the 1960 earthquake ended a recurrence interval that had begun almost four centuries before, with an earthquake documented by Spanish conquistadors in 1575. Two later earthquakes, in 1737 and 1837, produced little if any subsidence or tsunami at the estuary and they therefore probably left the fault partly loaded with accumulated plate motion that the 1960 earthquake then expended.