Browsing by Author "Contreras, Renato"
Now showing 1 - 18 of 18
Results Per Page
Sort Options
- ItemActivation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a snar Reaction(2018) Sanchez, Bruno; Calderon, Cristian; Tapia Apati, Ricardo; Contreras, Renato; Campodónico Galdames, Paola Rossana
- ItemChanges in the SNAr reaction mechanism brought about by preferential solvation(2015) Alarcon-Esposito, Jazmin; Tapia Apati, Ricardo; Contreras, Renato; Campodónico Galdames, Paola Rossana
- ItemEffect of the nature of the nucleophile and solvent on an SNAr reaction(2018) Gazitúa López, Marcela Ivonne; Tapia Apati, Ricardo; Contreras, Renato; Campodónico Galdames, Paola Rossana
- ItemElectrofugality index for benzhydryl derivatives(2007) Campodónico Galdames, Paola Rossana; Perez, Claudio; Aliaga Miranda, Margarita Elly; Gazitúa López, Marcela Ivonne; Contreras, Renato
- ItemExperimental and Theoretical Studies on the Nucleofugality Patterns in the Aminolysis and Phenolysis of S-Aryl O-Aryl Thiocarbonates(2009) Castro R., Enrique; Aliaga Miranda, Margarita Elly; Campodónico Galdames, Paola Rossana; Cepeda Plaza, Marjorie Valeria; Contreras, Renato; Santos Blanco, José Guillermo
- ItemExperimental and theoretical study on the oxidation mechanism of dopamine in n-octyl pyridinium based ionic liquids-carbon paste modified electrodes(2013) Díaz Navarro, Carlos Patricio; García, Camilo; Iturriaga Vásquez, Patricio; Aguirre, María Jesús; Muena, Juan; Contreras, Renato; Ormazabal Toledo, Rodrigo; Isaacs Casanova, Mauricio
- ItemGlobal and local analysis of the gas-phase acidity of haloacetic acids(2000) Perez, Patricia; Toro Labbé, Alejandro; Contreras, Renato
- ItemHydrogen Bond Contribution to Preferential Solvation in SNAr Reactions(2013) Ormazabal Toledo, Rodrigo; Santos, José G.; Ríos Santana, Paulina Loreto; Castro R., Enrique; Campodónico Galdames, Paola Rossana; Contreras, Renato
- ItemLewis Molecular Acidity of Ionic Liquids from Empirical Energy-Density Models(2013) Contreras, Renato; Aizman, Arie; Cerda Monje, Andrea; Tapia Apati, Ricardo
- ItemN-Heterocyclic carbene copper(I) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles(2016) Urzúa, Julio I.; Contreras, Renato; Salas Sánchez, Cristián Osvaldo; Tapia Apati, Ricardo
- ItemPhenoxy- and Phenylamino-Heterocyclic Quinones: Synthesis and Preliminary Anti-Pancreatic Cancer Activity(WILEY-V C H VERLAG GMBH, 2022) Sanchez, Patricio; Salas, Cristian O.; Gallardo-Fuentes, Sebastian; Villegas, Alondra; Veloso, Nicolas; Honores, Jessica; Inman, Martyn; Isaacs, Mauricio; Contreras, Renato; Moody, Christopher J.; Cisterna, Jonathan; Brito, Ivan; Tapia, Ricardo A.The successful application of fragment-based drug discovery strategy for the efficient synthesis of phenoxy- or phenylamino-2-phenyl-benzofuran, -benzoxazole and -benzothiazole quinones is described. Interestingly, in the final step of the synthesis of the target compounds, unusual results were observed on the regiochemistry of the reaction of bromoquinones with phenol and aniline. A theoretical study was carried out for better understanding the factors that control the regiochemistry of these reactions. The substituted heterocyclic quinones were evaluated in vitro to determine their cytotoxicity by the MTT method in three pancreatic cancer cell lines (MIA-PaCa-2, BxPC-3, and AsPC-1). Phenoxy benzothiazole quinone 26a showed potent cytotoxic activity against BxPC-3 cell lines, while phenylamino benzoxazole quinone 20 was the most potent on MIA-PaCa-2 cells. Finally, electrochemical properties of these quinones were determined to correlate with a potential mechanism of action. All these results, indicate that the phenoxy quinone fragment led to compounds with increased activity against pancreatic cancer cells.
- ItemPredicting the reaction mechanism of nucleophilic substitutions at carbonyl and thiocarbonyl centres of esters and thioesters(2012) Ormazábal Toledo, Rodrigo; Castro R., Enrique; Santos Blanco, José Guillermo; Millán Retamal, Daniela Andrea; Cañete Molina, Álvaro; Contreras, Renato; Campodónico Galdames, Paola Rossana
- ItemReactivity of benzohydrazide derivatives towards acetylation reaction. Experimental and theoretical studies(2010) Campodónico Galdames, Paola Rossana; Aliaga Miranda, Margarita Elly; Santos Blanco, José Guillermo; Castro R., Enrique; Contreras, Renato
- ItemRelationship between nucleophilicity electrophilicity indices and reaction mechanisms for the nucleophilic substitution reactions of carbonyl compounds(2004) Campodónico Galdames, Paola Rossana; Andrés, J.; Contreras, Renato
- ItemRelationships between the electrophilicity index and experimental rate coefficients for the aminolysis of thiolearbonates and dithiocarbonates(2005) Campodónico Galdames, Paola Rossana; Fuentealba, Patricio; Castro R., Enrique; Santos Blanco, José Guillermo; Contreras, Renato
- ItemSolvent effects in ionic liquids : empirical linear energy-density relationships(2012) Cerda Monje, A.; Aizman, Andrés; Tapia Apati, Ricardo; Chiappe, Cinzia; Contreras, Renato
- ItemSolvent effects on electrophilicity(2001) Pérez, Patricia; Toro Labbé, Alejandro; Contreras, Renato
- ItemSynthesis and characterization of poly (ionic liquid) derivatives of N-alkyl quaternized poly(4-vinylpyridine)(2018) Briones O., Ximena; Tapia Apati, Ricardo; Campodónico Galdames, Paola Rossana; Urzúa, Marcela; Leiva Campusano, Ángel; Contreras, Renato; González Navarrete, Javier