Browsing by Author "Copaja, M"

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    Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic heart failure
    (WILEY, 2005) Castro, P; Vukasovic, JL; Chiong, M; Diaz Araya, G; Alcaino, H; Copaja, M; Valenzuela, R; Greig, D; Perez, O; Corbalan, R; Lavandero, S
    Background: Our previous studies suggest that the increase in heart rate from rest to peak exercise is reduced in patients with chronic heart failure (CHF) and this is associated with increased oxidative stress, as determined by malondialdehyde (MDA) plasma levels.
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    Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure
    (EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2005) Castro, PF; Mc Nab, P; Quintana, JC; Bittner, A; Greig, D; Vergara, I; Vukasovic, JL; Corbalan, R; Copaja, M; Diaz Araya, G; Chiong, M; Troncoso, R; Alcaino, H; Lavandero, S
    Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 months of treatment with maximal tolerated doses of carvedilol. Patients with HF had significant ventricular dyssynchrony compared with a normal population. The 50th percentile of patients with the greatest dyssynchrony at baseline showed significant improvement in ventricular synchrony after receiving carvedilol, and this was correlated positively with a reduction in end-diastolic LV volumes. (c) 2005 Elsevier Inc. All rights reserved.