Browsing by Author "Cuevas, Ada"

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    A High-Fat Diet induces and red wine counteracts endothelial dysfuntion in human volunteers
    (2000) Cuevas, Ada; Germain Aravena, Alfredo M.; Leighton, Federico
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    Efficacy and safety of a very-low-calorie diet in a group of overweight or obese Chilean women
    (SOC MEDICA SANTIAGO, 2011) Cuevas, Ada; Cordero, Maria J.; Olivos, Cristina; Ghiardo, Daniella; Alvarez, Veronica
    Background: Very low calorie diets (VLCDs) have been used to induce a rapid decrease in total body weight. Aim: To evaluate the efficacy and safety of a VLCD in a group of overweight and obese Chilean women. Material and Methods: Thirty women with a body mass index (BMI) > 27 kg/m(2) were enrolled to a 4 weeks intervention with a VLCD (using liquid meal replacement). Anthropometric and metabolic parameters were evaluated at baseline and at the end of the intervention. Results: Twenty five women (83%) completed the total intervention period. Average weight loss was 5.7 +/- 1.5 kg (-6.9% of the initial weight) corresponding to a 34.7 +/- 13.4% of the excess of weight. Significant improvements in triglycerides, total cholesterol and LDL cholesterol (Low Density Lipoproteins) were observed. Insulin resistance determined by Homeostasis model assessment (HOMA), decreased significantly from 3.3 +/- 1.8 to 2.0 +/- 0.9 (p = 0.003). No serious adverse events were reported. Conclusions: Short term use of VLCDs is safe and effective to induce rapid weight loss in Chilean women. (Rev Med Chile 2011; 139: 1286-1291).
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    Molecular diagnosis and combined lipid lowering therapy of heterozygous familial hypercholesterolemia. Report of one case
    (SOC MEDICA SANTIAGO, 2007) Arteaga, Antonio; Cuevas, Ada; Rigotti, Attilio; Gonzalez, Francisco; Castillo, Sergio; Mata, Pedro; Alonso, Rodrigo
    Heterozygous familial hypercholesterolemia affects one every 400 individuals, is caused by mutations in the LDL receptor gene and is associated with premature coronary artery disease. Nowadays, LDL cholesterol can be efficiently reduced with the new therapies to reduce blood lipids. We report a female patient who consulted in 1975, when she was 46 years old, for severe hypercbolesterolemia. In 2003, a sample of leukocyte DNA was obtained and the uncommon 1705 + 1G > A mutation of the LDL receptorgene was detected. No mutations in the apolipoprotein B gene were,found. The patient was treated successfully with simvastatin SO mg/day and ezetimibe 10 mg/day and LDL cholesterol levels were reduced below 200 mg/dl.
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    Trends in obesity and diabetes prevalence in a Chilean urban population: 1993-2001
    (2008) Cuevas, Ada; Molina, Alfredo; Rigotti Rivera, Attilio; Miquel P., Juan Francisco; Marshall Rivera, Guillermo; Reyes, Soledad; Nervi, Flavio
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    Wine, Diet, Antioxidant Defenses, and Oxidative Damage
    (2002) Pérez, Druso D.; Cuevas, Ada; Leighton, Federico