Browsing by Author "Duarte, Ignacio"

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    Colitis de Crohn: Resultados del tratamiento quirúrgico y evolución alejada
    (2018) Imigo Gueregat, Felipe Andrés; Molina Pezoa, María Elena; Álvarez Lobos, Manuel; Quintana Villar, Carlos; Klaassen Lobos, Julieta Isabel; Torres Montes, Paula Javiera; Duarte, Ignacio; Bellolio R., Felipe; Zúñiga Díaz, Alvaro
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    Conversion to mycophenolate mofetil monotherapy in liver recipients: Calcineurin inhibitor levels are key
    (2017) Norero, Blanca; Serrano Honeyman, Carolina; Sánchez Fueyo, A.; Duarte, Ignacio; Torres Montes, Paula Javiera; Ocqueteau Tachini, Mauricio; Barrera Martínez, Francisco José; Arrese Jiménez, Marco; Soza, Alejandro; Benítez, Carlos
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    Effect of losartan on early liver fibrosis development in a rat model of nonalcoholic steatohepatitis
    (WILEY, 2007) Ibanez, Patricio; Solis, Nancy; Pizarro, Margarita; Aguayo, Gloria; Duarte, Ignacio; Miquel, Juan Francisco; Accatino, Luigi; Arrese, Marco
    Background and aim: Nonalcoholic steatohepatitis (NASH) is a metabolic disorder of the liver that may evolve into fibrosis or cirrhosis. Recent studies have shown reduction of experimental liver fibrosis with the use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor antagonists. The aim of this study was to determine whether losartan can influence the early phase of fibrogenesis in an animal model of NASH.
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    La escrófula en el siglo XIX.
    (2017) Duarte, Ignacio
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    From scrophula to mycobacterial lymphadenitis
    (SOC CHILENA INFECTOLOGIA, 2017) Duarte, Ignacio
    In the 19th century it was widely believed that both tuberculosis and cervical lymph node swelling, known as scrophula, affected individuals predisposed to an inherited "diathetic constitution". In 1882 Robert Koch proved that human tuberculosis and scrophulous lesions were caused by the bacillus Mycobacterium tuberculosis. In the early twentieth century it was stated that Mycobacterium bovis, the bacillus of cattle tuberculosis, could also cause cervical lymphoadenitis in humans, especially in children, by the intake of milk from sick cows. The incidence of this condition decreased after the infection was controlled in cattle and pasteurization of the milk was introduced. A type of granulomatous necrotizing and suppurative cervico-facial lymphadenitis associated to non-tuberculous mycobacteria was described in 1956. It mainly affects children younger than 5 years old, particularly those born in countries with non-endemic tuberculosis. Tuberculous cervical lymphadenitis is prevalent in young adults from tuberculosis-endemic countries and in HIV-infected subjects. Infectious etiology displaced the importance of a personal disposition in the development of scrophula. Nevertheless, mutations that confer susceptibility to mycobacterial infection are currently investigated.
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    Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency
    (2013) Harris D., Paul R.; Serrano Honeyman, Carolina; Villagrán Torres, Andrea Alejandra; Walker, Marjorie M.; Thomson, Melanie; Duarte, Ignacio; Windle, Henry J.; Crabtree, Jean E.
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    Historia de la escrófula : de la discrasia humoral a la consunción
    (2016) Duarte, Ignacio; Chuaqui Farrú, Claudia
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    ¿Influye el medio de preservación del injerto en los resultados y costos del trasplante hepático de donante fallecido? comparación de dos soluciones de preservación
    (2014) Martínez Castillo, Jorge; Bachler, J.; Moisan, F.; Torres Montes, Paula Javiera; Duarte, Ignacio; Pérez Ayuso, Rosa María; Benítez, Carlos; Arrese Jiménez, Marco; Domínguez, P.; Guerra Castro, Juan Francisco; Jarufe Cassis, Nicolás
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    Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-beta
    (LIPPINCOTT WILLIAMS & WILKINS, 2011) Serrano, Carolina A.; Talesnik, Eduardo; Pena, Alfredo; Rollan, Antonio; Duarte, Ignacio; Torres, Javiera; Majerson, Daniela; Einisman, Helly; Viviani, Paola; Harris, Paul R.
    Objectives We evaluated allergy/hypersensitivity clinical markers and their correlation with Helicobactor pylori infection in children and adults to analyze how early acquisition of H. pylori could modulate allergic disorder expression.
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    Lack of Diagnostic Utility of Specific Immunoglobulin M in Helicobacter pylori Infection in Children
    (LIPPINCOTT WILLIAMS & WILKINS, 2008) Serrano, Carolina A.; Gonzalez, Carmen G.; Rollan, Antonio R.; Duarte, Ignacio; Torres, Javiera; Pena, Alfredo J.; Harris, Paul R.
    Background: Helicobacter pylori infection results in ill a systemic immune response characterized by the initial rise of immunoglobulin (Ig) M followed by the elevation of IgG and IgA-specific antibody levels in serum. Age and regional considerations may modify the accuracy of serological tests.
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    Long-term survival in carcionoid tumour of the appendix. An analysis of 8903 appendectomies
    (ELSEVIER DOYMA SL, 2009) Michel Butte, Jean; Angelica Garcia Huidobro, Maria; Torres, Javiera; Duarte, Ignacio; Zuniga, Alvaro; Llanos, Osvaldo
    Introduction: Appendiceal carcinoids are the most frequent tumors of the appendix and are usually detected as an incidental finding in the final pathology report. The aim of this study was to evaluate the clinical and pathological characteristics, surgical treatment and long-term survival in patients with an appendiceal carcinoid tumor.
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    Overexpression of p73 as a Tissue Marker for High-Risk Gastritis
    (AMER ASSOC CANCER RESEARCH, 2010) Carrasco, Gonzalo; Diaz, Jose; Valbuena, Jose R.; Ibanez, Paulina; Rodriguez, Paz; Araya, Gabriela; Rodriguez, Carolina; Torres, Javiera; Duarte, Ignacio; Aravena, Edmundo; Mena, Fernando; Barrientos, Carlos; Corvalan, Alejandro H.
    Purpose: Histologic assessment of high-risk gastritis for the development of gastric cancer is not well defined. The identification of tissue markers together with the integration of histologic features will be required for this assessment.
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    Peptic Ulcer Disease in Helicobacter pylori-Infected Children : Clinical Findings and Mucosal Immune Response
    (2014) Hernández C.; Serrano Honeyman, Carolina; Einisman, H.; Villagrán, A.; Peña Villegas, Alfredo Javier; Duarte, Ignacio; Torres Montes, Paula Javiera; Riera Cassorla, Francisca Paz; Harris D., Paul R.; Hernández C.; Serrano Honeyman, Carolina; Einisman, H.; Villagrán, A.; Peña Villegas, Alfredo Javier; Duarte, Ignacio; Torres Montes, Paula Javiera; Riera Cassorla, Francisca Paz; Harris D., Paul R.
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    Portal hypertension and acute liver failure as uncommon manifestations of primary amyloidosis
    (2014) Norero, B.; Perez Ayuso, Rosa Maria; Duarte, Ignacio; Ramírez Villanueva, Pablo Antonio; Soza, Alejandro; Arrese Jiménez, Marco; Benítez, Carlos
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    Scrofula in the 19th century
    (SOC CHILENA INFECTOLOGIA, 2017) Duarte, Ignacio
    In the 19th century scrofula or scrofulous adenitis was a frequent condition estimated by the finding of swollen cervical lymph nodes or scars, occurring in both sexes at all epochs of life, mainly in children. It was thought that it principally affected people with an inherited phlegmatic constitution that involved a scrofulous disposition or "diathesis". The disease would be triggered by environmental agents, bad habits or excesses in style of life. Besides injuring cervical lymph nodes, in some cases scrofula could compromise other groups of lymph nodes, bones, joints, lungs or other viscera. In some of its clinical presentations the disease could be healed while others were often lethal disorders. The finding of multiorgan compromise, caseation and "tuberculization" of the lesions originated discussion whether scrofula and tuberculosis were one or two different diseases and if they affected subjects with a common diathesis or people with a distinct scrofulous or tuberculous diathesis. Along the 19th century, before the discovery of Koch's bacillus, the notion of contagion as a cause of scrofula and tuberculosis was not predominant in Europe.
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    Sobrevida alejada de pacientes operados por cáncer gástrico incipiente
    (2008) Butte Barrios, Jean Michel Domingo; Torres Montes, Paula Javiera; Viviani García, Paola; Duarte, Ignacio; Crovari Eulufi, Fernando; Guzmán Karadima, Sergio; Cabrera Valenzuela, José Roberto; Pedemonte Trewhela, Juan Cristóbal; Llanos López, Osvaldo
    Background: Early gastric cancer involves mucosa and submucosa, independent of lymph node involvement. Radical gastrectomy is the standard treatment. Aim: To assess long term survival of patients operated for an early gastric cancer. Material and methods: Retrospective Rev iew of medical and pathology records of patients subjected to a gastrectomy for an early gastric cancer, between 1975 and 2002. All were treated using a standardized protocol and staged according to 2002 TNM classification of the American Joint Committee of Cáncer (AJCC). Demographic and pathologic features, operation performed and long term survival were recorded. Survival was analyzed using Kaplan-Meier method. Results: The series is comprised by 64 males and 41 females aged 61 + 1 years. Tumor was located in the upper third of the stomach on 33 subjects and a total gastrectomy was performed in 53. Pathology showed an intestinal type adenocarcinoma in 82 and a diffuse type in 23. In patients with involvement of mucosa and submucosa, 24 ± 14 and 22 ± 14 lymph nodes were excised, respectively. Lymph node involvement was present in 8% and 22% of patients with involvement of mucosa and submucosa, respectively. Five years survival was 94% and 78% in patients without and with lymph node involvement, respectively. Survival among patients in stage IA and IB was 94% and 76%, respectively. Multivariate analysis showed that the lymph node involvement was an independent mortality risk factor. Conclusions: Total gastrectomy in patients with early gastric cancer is associated with a good survival. Lymph node involvement is a mortality risk factor.
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    Steatotic livers. Can we use them in OLTX? Outcome data from a prospective baseline liver biopsy study
    (MEXICAN ASSOC HEPATOLOGY, 2012) Gabriel, Mauricio; Moisan, Fabrizio; Vidal, Marcela; Duarte, Ignacio; Jimenez, Macarena; Izquierdo, Guillermo; Dominguez, Pilar; Mendez, Javier; Soza, Alejandro; Benitez, Carlos; Perez, Rosa; Arrese, Marco; Guerra, Juan; Jarufe, Nicolas; Martinez, Jorge
    Introduction. Steatotic livers have been associated with greater risk of allograft dysfunction in liver transplantation. Our aim was to determinate the prevalence of steatosis in grafts from deceased donors in Chile and to assess the utility of a protocol-bench biopsy as an outcome predictor of steatotic grafts in our transplant program. Material and methods. We prospectively performed protocol-bench graft biopsies from March 2004 to January 2009. Biopsies were analyzed and classified by two independent pathologists. Steatosis severity was graded as normal from absent to < 6%; grade 1: 6-33%; grade 2: > 33-66% and grade 3: > 66%. Results. We analyzed 58 liver grafts from deceased donors. Twenty-nine grafts (50%) were steatotic; 9 of them (16%) with grade 3. Donor age (p < 0.001) and BMI over 25 kg/m(2) (p = 0.012) were significantly associated with the presence of steatosis. There were two primary non-functions (PNF); both in a grade 3 steatotic graft. The 3-year overall survival was lower among recipients with macrovesicular steatotic graft (57%) than recipients with microvesicular (85%) or non-steatotic grafts (95%) (p = 0.026). Conclusion. Macrovesicular steatosis was associated with a poor outcome in this series. A protocol bench-biopsy would be useful to identify these grafts.
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    Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: A case report with a long term follow-up
    (ELSEVIER ESPANA, 2011) Salech, Felipe; Valderrama, Sebastian; Nervi, Bruno; Carlos Rodriguez, Juan; Oksenberg, Danny; Koch, Alvaro; Smok, Gladys; Duarte, Ignacio; Maria Perez Ayuso, Rosa; Jarufe, Nicolas; Martinez, Jorge; Soza, Alejandro; Arrese, Marco; Riquelme, Arnoldo
    Hepatic epithelioid hemangioendothelioma (HEH) is an unusual, low-grade malignant vascular tumor of the liver. Here we describe a case of a 40-year-old woman who presented with abdominal pain in the upper right quadrant and giant hepatomegaly, in which imaging studies and a fine-needle liver biopsy confirmed the presence of a large EHE with an isolated lung metastasis. After balancing all possible therapeutic modalities the patient was treated conservatively with thalidomide (300 mg/day). The drug was well tolerated with minimal toxicity and the patient continues on therapy 109 months after treatment was started with no disease progression. Current therapeutic options for HEH are discussed in light of the clinical case with particular emphasis on anti-angiogenic therapies.