Browsing by Author "Duran-Aniotz, Claudia"

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    Allostatic-Interoceptive Overload in Frontotemporal Dementia
    (2022) Birba, Agustina; Santamaria-Garcia, Hernando; Prado, Pavel; Cruzat, Josefina; Sainz Ballesteros, Agustin; Legaz, Agustina; Fittipaldi, Sol; Duran-Aniotz, Claudia; Slachevsky, Andrea; Santibanez, Rodrigo; Sigman, Mariano; Garcia, Adolfo M.; Whelan, Robert; Moguilner, Sebastian; Ibanez, Agustin
    BACKGROUND: The predictive coding theory of allostatic-interoceptive load states that brain networks mediating autonomic regulation and interoceptive-exteroceptive balance regulate the internal milieu to anticipate future needs and environmental demands. These functions seem to be distinctly compromised in behavioral variant frontotemporal dementia (bvFTD), including alterations of the allostatic-interoceptive network (AIN). Here, we hypothesize that bvFTD is typified by an allostatic-interoceptive overload.
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    Biomarkers for dementia in Latin American countries: Gaps and opportunities
    (2023) Parra, Mario A.; Orellana, Paulina; Leon, Tomas; Victoria, Cabello G.; Henriquez, Fernando; Gomez, Rodrigo; Avalos, Constanza; Damian, Andres; Slachevsky, Andrea; Ibanez, Agustin; Zetterberg, Henrik; Tijms, Betty M.; Yokoyama, Jennifer S.; Pina-Escudero, Stefanie D.; Cochran, J. Nicholas; Matallana, Diana L.; Acosta, Daisy; Allegri, Ricardo; Arias-Suarez, Bianca P.; Barra, Bernardo; Behrens, Maria Isabel; Brucki, SoniaM. D.; Busatto, Geraldo; Caramelli, Paulo; Castro-Suarez, Sheila; Contreras, Valeria; Custodio, Nilton; Dansilio, Sergio; De la Cruz-Puebla, Myriam; de Souza, Leonardo Cruz; Diaz, Monica M.; Duque, Lissette; Farias, Gonzalo A.; Ferreira, Sergio T.; Guimet, Nahuel Magrath; Kmaid, Ana; Lira, David; Lopera, Francisco; Meza, Beatriz Mar; Miotto, Eliane C.; Nitrini, Ricardo; Nunez, Alberto; O'Neill, Santiago; Ochoa, John; Pintado-Caipa, Maritza; Resende, Elisa de Paula Franca; Risacher, Shannon; Rojas, Luz Angela; Sabaj, Valentina; Schilling, Lucas; Sellek, Allis F.; Sosa, Ana; Takada, Leonel T.; Teixeira, Antonio L.; Unaucho-Pilalumbo, Martha; Duran-Aniotz, Claudia
    Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.
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    Multiscale entropy analysis of retinal signals reveals reduced complexity in a mouse model of Alzheimer's disease
    (NATURE PORTFOLIO, 2022) Araya-Arriagada, Joaquín; Garay, Sebastián; Rojas González, Luis Cristóbal; Duran-Aniotz, Claudia; Palacios, Adrián G.; Chacón, Max; Medina, Leonel E.
    Alzheimer's disease (AD) is one of the most significant health challenges of our time, affecting a growing number of the elderly population. In recent years, the retina has received increased attention as a candidate for AD biomarkers since it appears to manifest the pathological signatures of the disease. Therefore, its electrical activity may hint at AD-related physiological changes. However, it is unclear how AD affects retinal electrophysiology and what tools are more appropriate to detect these possible changes. In this study, we used entropy tools to estimate the complexity of the dynamics of healthy and diseased retinas at different ages. We recorded microelectroretinogram responses to visual stimuli of different nature from retinas of young and adult, wild-type and 5xFAD-an animal model of AD-mice. To estimate the complexity of signals, we used the multiscale entropy approach, which calculates the entropy at several time scales using a coarse graining procedure. We found that young retinas had more complex responses to different visual stimuli. Further, the responses of young, wild-type retinas to natural-like stimuli exhibited significantly higher complexity than young, 5xFAD retinas. Our findings support a theory of complexity-loss with aging and disease and can have significant implications for early AD diagnosis.
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    The impact of SARS-CoV-2 in dementia across Latin America: A call for an urgent regional plan and coordinated response
    (2020) Ibanez, Agustin; Santamaria-Garcia, Hernando; Guerrero Barragan, Alejandra; Kornhuber, Alexander; Marques Ton, Alyne Mendonca; Slachevsky, Andrea; Lucio Teixeira, Antonio; Mar Meza, Beatriz Marcela; Serrano, Cecilia M.; Cano, Carlos; Arias Gonzalez, Carolina; Gonzalez-Billault, Christian; Butler, Christopher; Bustin, Julian; Duran-Aniotz, Claudia; Acosta, Daisy; Matallana, Diana L.; Acosta-Alvear, Diego; Trepel, Dominic; Franca Resende, Elisa De Paula; Ferreira Oliveira, Fabricio; Ibanez, Francisco; De Felice, Fernanda G.; Navarrete, Gorka; Tarnanas, Ioannis; Meier, Irene B.; Smid, Jerusa; Llibre-Guerra, Jorge; Llibre-Rodriguez, Juan J.; Fajersztajn, Lais; Takada, Leonel Tadao; Duque, Lissette; de Oliveira, Maira Okada; Camargos Bicalho, Maria Aparecida; Isabel Behrens, Maria; Pintado-Caipa, Maritza; Parra, Mario; Wilson, Maxwell Z.; De la Cruz Puebla, Myriam; Custodio, Nilton; Santibanez, Rodrigo; Serafim, Rodrigo Bernardo; Tavares, Ronnielly Melo; Pina Escudero, Stefanie Danielle; Leon Rodriguez, Tomas; Dawson, Walter; Miller, Bruce L.; Kosik, Kenneth S.
    The SARS-CoV-2 global pandemic will disproportionately impact countries with weak economies and vulnerable populations including people with dementia. Latin American and Caribbean countries (LACs) are burdened with unstable economic development, fragile health systems, massive economic disparities, and a high prevalence of dementia. Here, we underscore the selective impact of SARS-CoV-2 on dementia among LACs, the specific strain on health systems devoted to dementia, and the subsequent effect of increasing inequalities among those with dementia in the region. Implementation of best practices for mitigation and containment faces particularly steep challenges in LACs. Based upon our consideration of these issues, we urgently call for a coordinated action plan, including the development of inexpensive mass testing and multilevel regional coordination for dementia care and related actions. Brain health diplomacy should lead to a shared and escalated response across the region, coordinating leadership, and triangulation between governments and international multilateral networks.