Browsing by Author "Espinosa Bustos, Christian Marcelo"
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- Item2-Phenylaminonaphthoquinones and related compounds : synthesis, trypanocidal and cytotoxic activities(2014) Sieveking, Ivan; Thomas Riveros, Pablo Ignacio; Estévez, Juan C.; Quiñones, Natalia; Cuéllar, Mauricio A.; Villena, Juan; Espinosa Bustos, Christian Marcelo; Fierro Huerta, Angélica; Tapia Apati, Ricardo; Salas, Cristian A.
- ItemA convenient and simple synthesis of N-arylpirrolopyrimidines using boronic acids and promoted by copper (II) acetate(2017) Espinosa Bustos, Christian Marcelo; Villegas Menares, Alondra Elena; Salas Sánchez, Cristián Osvaldo
- ItemComparative Study of Phenolic Content and Antioxidant and Hepatoprotective Activities of Unifloral Quillay Tree (Quillaja saponaria Molina) and Multifloral Honeys from Chile(2024) Núñez Pizarro, Paula; Montenegro Rizzardini, Gloria; Núñez Quijada, Gabriel Israel; Andía Kohnenkampf, Marcelo Edgardo; Espinosa Bustos, Christian Marcelo; de Camargo, Adriano Costa; Oyarzún Isamitt, Juan Esteban; Bridi, RaquelHoney is a natural sweet element that bees make with flower nectar, revered for its distinct flavor, nutritional value, and potential health benefits. Chilean beekeeping has a diverse range of honey varieties, many of which are unique. The quillay (Quillaja saponaria Molina, soapbark tree) is a Chilean endemic tree whose honey has not been studied in depth. We characterized various Chilean honeys with different botanical origins, with a particular focus on quillay tree honey, analyzing its total phenolic and flavonoid content and its antioxidant activities. Cytotoxicity and hepatoprotective activity were also evaluated using HuH-7 cells. The Spearman correlation between the percentage of quillay pollen in the honey samples and the total phenolic content (R = 0.72; p < 0.05), plus the oxygen radical absorbance capacity, suggests that compounds from quillay contribute to the overall antioxidant capacity of honey. Unifloral quillay honey extracts also protect hepatic cells from oxidative damage induced by peroxyl radicals generated by AAPH. This analysis sheds light on the potential of quillay tree honey, underscoring its significance as a natural source of bioactive phenolic compounds with possible hepatoprotective effects.
- ItemDesign, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1(2015) Espinosa Bustos, Christian Marcelo; Lagos, Carlos F.; Romero Parra, Javier Hernán; Zárate Méndez, Ana María; Mella Raipán, Jaime Alberto; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo; Iturriaga Vásquez, Patricio; Tapia Apati, Ricardo; Pessoa Mahana, Carlos David
- ItemDesign, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstituted-1,2,4,5-tetrazine derivatives as potential antitumor agents(2017) Cañete Molina, Álvaro; Espinosa Bustos, Christian Marcelo; González Castro, Marcos; Faundez, Mario; Mella, Jaime; Tapia Apati, Ricardo; Cabrera Caballero, Alan Raúl; Brito, Iván; Aguirre, Adam; Salas Sánchez, Cristián Osvaldo
- ItemdsDNA sensing capabilities of metallopolymers electrochemically deposited from ruthenium-pyrrole and - thiophene complexes(2019) Valle de la Cortina, María Angélica del; González Del Castillo, Beatriz; Espinosa Bustos, Christian Marcelo; Ramirez, A.M.; Gacitúa Santelices, Manuel Alejandro; Hernandez, L.A.
- ItemEnrofloxacin behavior in presence of soil extracted organic matter : an electrochemical approach(2017) Antilen, Mónica; Valencia, C.; Peralta, E.; Canales, C.; Espinosa Bustos, Christian Marcelo; Escudey, M.
- ItemEvaluation of the Membrane Permeability (PAMPA and Skin) of Benzimidazoles with Potential Cannabinoid Activity and their Relation with the Biopharmaceutics Classification System (BCS)(2011) Alvarez Figueroa, María Javiera; Pessoa Mahana, Carlos David; Palavecino-Gonzalez, M. Elisa; Mella Raipán, Jaime Alberto; Espinosa Bustos, Christian Marcelo; Lagos-Munoz, Manuel E.
- ItemFirst Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H3R Ligands with Antioxidant Properties(2024) Werner T.; Añazco Martínez, Tito Alonso; Osses-Mendoza P.; Castro-Alvarez A.; Salas Sánchez, Cristián Osvaldo; Bridi R.; Stark H.; Espinosa Bustos, Christian MarceloNeurodegenerative diseases are a major public health problem due to the aging population and multifaceted pathology; therefore, the search for new therapeutic alternatives is of the utmost importance. In this sense, a series of six 1-(3-phenoxypropyl)piperidines alkyl-linked to a triphenylphosphonium cation derivative were synthesized as H3R ligands with antioxidant properties to regulate excessive mitochondrial oxidative stress and contribute to potential new therapeutic approaches for neurodegenerative diseases. Radioligand displacement studies revealed high affinity for H3R with Ki values in the low to moderate two-digit nanomolar range for all compounds. Compound 6e showed the highest affinity (Ki H3R = 14.1 nM), comparable to that of pitolisant. Antioxidative effects were evaluated as radical-scavenging properties using the ORAC assay, in which all derivatives showed low to moderate activity. On the other hand, cytotoxic effects in SH-SY5Y neuroblastoma cells were investigated using the colorimetric alamar blue assay, which revealed significant effects on cell viability with an unequivocally structure–toxicity relationship. Finally, docking and molecular simulation studies were used to determine the H3R binding form, which will allow us to further modify the compounds to establish a robust structure-activity relationship and find a lead compound with therapeutic utility in neurodegenerative diseases.
- ItemFluorescence properties of aurone derivatives: an experimental and theoretical study with some preliminary biological applications(2017) Espinosa Bustos, Christian Marcelo; Cortes Arriagada, Diego; Soto Arriaza, Marco; Robinson Duggon, José Luis; Pizarro, Nancy; Cabrera Caballero, Alan Raúl; Fuentealba Patiño, Denis Alberto; Salas Sánchez, Cristián Osvaldo
- ItemHepatoprotective species from the Chilean medicinal flora : Junellia spathulata (Verbenaceae)(2021) Bridi, Raquel; Lino von Poser, G.; Gómez, Miguel; Andía Kohnenkampf, Marcelo Edgardo; Oyarzún Isamitt, Juan Esteban; Núñez, P.; Vasquez Arias, A. J.; Espinosa Bustos, Christian Marcelo
- ItemNature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H-3 receptor(2019) Frank, A.; Meza-Arriagada, F.; Salas Sánchez, Cristián Osvaldo; Espinosa Bustos, Christian Marcelo; Stark, H.
- ItemNew 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia(2020) Bertrand, J; Dostalova, H; Krystof, V; Jorda, R; Castro, A; Mella, J; Espinosa Bustos, Christian Marcelo; Zárate Méndez, Ana María; Salas Sánchez, Cristián Osvaldo
- ItemNew aryloxy-quinone derivatives as potential anti-Chagasic agents : synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis(2015) Vázquez, K.; Espinosa Bustos, Christian Marcelo; Soto, J.; Tapia, R.; Varela, J.; Birriel, E.; Segura Segura, Rodrigo; Pizarro, J.; Cerecetto, H.; González, M.; Paulino, M.; Salas, C.
- ItemNew aryloxy-quinone derivatives with promising activity on Trypanosoma cruzi(2020) Espinosa Bustos, Christian Marcelo; Vazquez, K; Varela, J; Cerecetto, H; Paulino, M; Segura, R; Pizarro, J; Vera, B; Gonzalez, M; Zárate Méndez, Ana María; Salas, CO
- ItemNew imidoyl-indazole platinum (II) complexes as potential anticancer agents: Synthesis, evaluation of cytotoxicity, cell death and experimentaltheoretical DNA interaction studies(2017) Cabrera Caballero, Alan Raúl; Espinosa Bustos, Christian Marcelo; Faundez, Mario; Meléndez Rojel, Jaime Gumercindo; Jaque Olmedo, Pablo César; Daniliuc, Constantin G.; Aguirre Ducler, Adam Jesús; Rojas Guerrero, René; Salas Sánchez, Cristián Osvaldo
- ItemNew lead elements for histamine H3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class(2018) Espinosa Bustos, Christian Marcelo; Frank, Annika; Arancibia Opazo, Sandra; Salas Sánchez, Cristián Osvaldo; Fierro Huerta, Angélica; Stark, Holger
- ItemSynthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents(2014) Tapia Apati, Ricardo; Salas Sánchez, Cristián Osvaldo; Vazquez, K.; Espinosa Bustos, Christian Marcelo; Soto Delgado, J.; Varela, J.; Birriel, E.; Cerecetto, H.; González, M.; Paulino, M.
- ItemSynthesis and electrochemical characterization of new ruthenium-terthiophene complexes(2015) González, B.; Valle Delaware la Cortina, María Angélica del; Díaz, F. R.; Espinosa Bustos, Christian Marcelo; Ramírez, A.; Hernández, L. A.; González, B.; Valle Delaware la Cortina, María Angélica del; Díaz, F. R.; Espinosa Bustos, Christian Marcelo; Ramírez, A.; Hernández, L. A.
- ItemSynthesis and Pharmacophore Modelling of 2.6.9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines(2015) Calderón Arancibia, Jeannette; Espinosa Bustos, Christian Marcelo; Cañete Molina, Álvaro; Tapia Apati, Ricardo; Faúndez Cáceres, Mario; Torres Torres, María José; Aguirre, Adam; Paulino, Margot; Salas Sánchez, Cristián Osvaldo