Browsing by Author "Eugenin, J."
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- ItemD-serine regulation of the timing and architecture of the inspiratory burst in neonatal mice(2020) Beltrán Castillo, S.; Olivares, M. J.; Ochoa, M.; Barria, J.; Chacón, Matías F.; Bernhardi Montgomery, Rommy von; Eugenin, J.
- ItemDevelopment and pH sensitivity of the respiratory rhythm of fetal mice in vitro(PERGAMON-ELSEVIER SCIENCE LTD, 2006) Eugenin, J.; Von Bernhardi, R.; Muller, K. J.; Llona, I.In newborn and adult mammals, chemosensory drive exerted by CO2 and H+ provides an essential tonic input: without it the rhythm of respiration is abolished. It is not known, however, whether this chemosensory drive and the respiratory rhythm appear simultaneously during development. In isolated brainstem-spinal cord preparations from fetal mice, we determined at what stage of fetal life the respiratory rhythm appeared in third to fifth cervical ventral roots (phrenic motoneurons) and whether this fetal rhythm was sensitive to chemosensory inputs. A respiratory-like rhythm consisting of short duration bursts of discharges recurring at 2-16 min(-1) was detected in two of nine embryonic day 13 fetuses; it was abolished by transection of the spinal cord between the first to second cervical segments and was phase-related to rhythmic activity from medullary units of the ventral respiratory group. At embryonic day 13, it coexisted with a slow rhythm (0.1-2.0 min(-1)) of long duration bursts of action potentials which was generated by the spinal cord. At later fetal stages, the respiratory-like rhythm became more robust and of higher frequency, while the spinal cord rhythm became less obvious. At all fetal stages, acidification of the superfusion medium from pH 7.5-7.2 or 7.4-7.3 or 7.4 to 7.2 increased the frequency of both the respiratory-like and the spinal cord rhythms. In addition, acidification reduced the amplitude of the integrated burst activity of the spinal cord rhythm of embryonic day 13-embryonic day 16 fetuses and the respiratory-like rhythm of embryonic day 17 and older fetuses. Our results indicate that the rhythms transmitted by phrenic motoneurons during fetal development are chemosensitive from early fetal stages. Through its effects on induction and patterning of the rhythm, chemosensory drive may play a role in activity-dependent formation of respiratory neural networks. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.
- ItemExpression Pattern of Scavenger Receptors and Amyloid-beta Phagocytosis of Astrocytes and Microglia in Culture are Modified by Acidosis: Implications for Alzheimer's Disease(2016) Eugenin, J.; Vecchiola Cárdenas, Andrea Paola; Murgas, P.; Arroyo, P.; Cornejo, F.; Bernhardi Montgomery, Rommy von
- ItemFunctional Recovery of the Ventilatory Chemoreflexes After Partial Chronic Denervation of the Nucleus Tractus Solitarius(1990) Eugenin, J.; Zapata, Patricio
- ItemGlial Cells and Integrity of the Nervous System(2016) Bernhardi Montgomery, Rommy von; Eugenin, J.; Flores, B.; Leon, J.
- ItemImpact of Aging in Microglia-Mediated D-Serine Balance in the CNS(2018) Beltran-Castillo, S.; Eugenin, J.; Bernhardi Montgomery, Rommy von
- ItemTGF beta 1-Smad3 signaling mediates the formation of a stable serine racemase dimer in microglia(2020) Beltrán Castillo, S.; Trivino, J. J.; Eugenin, J.; von Bernhardi, R.