Browsing by Author "Feleszko, Wojciech"

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    Addition of long‐acting beta‐agonists to inhaled corticosteroids for asthma in preschool children: A systematic review
    (W.B. Saunders Ltd, 2024) Ambrozej, Dominika; Cieslik, Cieslik; Feleszko, Wojciech; Rodriguez-Martinez, Carlos E.; Castro Rodríguez, José Antonio
    Inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA) are essential in asthma management, but the guidelines for treatment in preschool children remain heterogeneous worldwide. This systematic review evaluates the efficacy and safety of LABA + ICS therapy in asthmatic children under six years. We searched four databases, identifying six eligible studies (n = 1415 preschoolers), and in all the LABA used was salmeterol. Due to high heterogeneity, quantitative analysis was not feasible. Three before-and-after studies demonstrated significant reductions in unscheduled visits and hospitalizations due to asthma exacerbations with LABA + ICS. One RCT showed fewer exacerbations in the LABA + ICS group compared to ICS alone. Night-time awakenings decreased significantly in two studies but not in one RCT. Improvements in lung function using impulse oscillometry and FeNO levels were noted with LABA+ICS in one RCT. No significant adverse effects were reported. Despite positive findings, high-quality trials are needed to confirm these results, particularly using formoterol as LABA, aligning with the recommendations. Further research is imperative to optimize asthma management in preschool children.
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    Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multinational cohort
    (2021) Papadopoulos, Nikolaos G.; Mathioudakis, Alexander G.; Custovic, Adnan; Deschildre, Antoine; Phipatanakul, Wanda; Wong, Gary; Xepapadaki, Paraskevi; Abou-Taam, Rola; Agache, Ioana; Castro-Rodriguez, Jose A.; Chen, Zhimin; Cros, Pierrick; Dubus, Jean-Christophe; El-Sayed, Zeinab Awad; El-Owaidy, Rasha; Feleszko, Wojciech; Fierro, Vincenzo; Fiocchi, Alessandro; Garcia-Marcos, Luis; Goh, Anne; Hossny, Elham M.; Huerta Villalobos, Yunuen R.; Jartti, Tuomas; Le Roux, Pascal; Levina, Julia; Lopez Garcia, Aida Ines; Ramos, Angel Mazon; Morais-Almeida, Mario; Murray, Clare; Nagaraju, Karthik; Nagaraju, Major K.; Navarrete Rodriguez, Elsy Maureen; Namazova-Baranova, Leyla; Nieto Garcia, Antonio; Pozo Beltran, Cesar Fireth; Ratchataswan, Thanaporn; Rivero Yeverino, Daniela; Rodriguez Zagal, Erendira; Schweitzer, Cyril E.; Tulkki, Marleena; Wasilczuk, Katarzyna; Xu, Dan
    Background The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes.
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    Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden
    (2020) Papadopoulos, Nikolaos G.; Custovic, Adnan; Deschildre, Antoine; Mathioudakis, AleXander G.; Phipatanakul, Wanda; Wong, Gary; Xepapadaki, Paraskevi; Agache, Ioana; Bacharier, Leonard; Bonini, Matteo; Castro-Rodriguez, Jose A.; Chen, Zhimin; Craig, Timothy; Ducharme, Francine M.; El-Sayed, Zeinab AWad; Feleszko, Wojciech; Fiocchi, Alessandro; Garcia-Marcos, Luis; Gern, James E.; Goh, Anne; Gomez, Rene MaXimiliano; Hamelmann, Eckard H.; Hedlin, Gunilla; Hossny, Elham M.; Jartti, Tuomas; Kalayci, Omer; Kaplan, Alan; Konradsen, Jon; Kuna, Piotr; Lau, Susanne; Souef, Peter Le; Lemanske, Robert F.; Makela, Mika J.; Morais-Almeida, Manio; Murray, Clare; Nagaraju, Karthik; Namazova-Baranova, Leyla; Garcia, Antonio Nieto; Yusuf, Osman M.; Pitrez, Paulo M. C.; Pohunek, Petr; Beltran, Cesar Fireth Pozo; Roberts, Graham C.; Valiulis, Arunas; Zar, Heather J.
    BACKGROUND: It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic.
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    Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank
    (2021) Mathioudakis, Alexander G.; Miligkos, Michael; Boccabella, Cristina; Alimani, Gioulinta S.; Custovic, Adnan; Deschildre, A.; Ducharme, Francine Monique; Kalayci, Omer; Murray, Clare; Garcia, Antonio Nieto; Phipatanakul, Wanda; Price, David; Sheikh, Aziz; Agache, Ioana Octavia; Bacharier, Leonard; Beloukas, Apostolos; Bentley, Andrew; Bonini, Matteo; Castro-Rodriguez, Jose A.; De Carlo, Giuseppe; Craig, Timothy; Diamant, Zuzana; Feleszko, Wojciech; Felton, Tim; Gern, James E.; Grigg, Jonathan; Hedlin, Gunilla; Hossny, Elham M.; Ierodiakonou, Despo; Jartti, Tuomas; Kaplan, Alan; Lemanske, Robert F.; Le Souef, Peter N.; Makela, Mika J.; Mathioudakis, Georgios A.; Matricardi, Paolo; Mitrogiorgou, Marina; Morais-Almeida, Mario; Nagaraju, Karthik; Papageorgiou, Effie; Pite, Helena; Pitrez, Paulo M. C.; Pohunek, Petr; Roberts, Graham; Tsiligianni, Ioanna; Turner, Stephen; Vijverberg, Susanne; Winders, Tonya A.; Wong, Gary W. K.; Xepapadaki, Paraskevi; Zar, Heather J.; Papadopoulos, Nikolaos G.
    Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted. Methods and analysis Standard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively. Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence. Ethics and dissemination Ethics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank. PROSPERO registration numbers CRD42020132990, CRD42020171624.
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    Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO
    (2024) Papadopoulos, Nikolaos G.; Custovic, Adnan; Deschildre, Antoine; Gern, James E.; Nieto Garcia, Antonio; Miligkos, Michael; Phipatanakul, Wanda; Wong, Gary; Xepapadaki, Paraskevi; Agache, Ioana; Arasi, Stefania; El-Sayed, Zeinab Awad; Bacharier, Leonard B.; Bonini, Matteo; Braido, Fulvio; Caimmi, Davide; Castro-Rodriguez, Jose A.; Chen, Zhimin; Clausen, Michael; Craig, Timothy; Diamant, Zuzana; Ducharme, Francine M.; Ebisawa, Motohiro; Eigenmann, Philippe; Feleszko, Wojciech; Fierro, Vincezo; Fiocchi, Alessandro; Garcia-Marcos, Luis; Goh, Anne; Gomez, Rene Maximiliano; Gotua, Maia; Hamelmann, Eckard; Hedlin, Gunilla; Hossny, Elham M.; Ispayeva, Zhanat; Jackson, Daniel J.; Jartti, Tuomas; Jesenak, Milos; Kalayci, Omer; Kaplan, Alan; Konradsen, Jon R.; Kuna, Piotr; Lau, Susanne; Le Souef, Peter; Lemanske, Robert F.; Levin, Michael; Makela, Mika J.; Mathioudakis, Alexander G.; Mazulov, Oleksandr; Morais-Almeida, Mario; Murray, Clare; Nagaraju, Karthik; Novak, Zoltan; Pawankar, Ruby; Pijnenburg, Marielle W.; Pite, Helena; Pitrez, Paulo M.; Pohunek, Petr; Price, David; Priftanji, Alfred; Ramiconi, Valeria; Rivero Yeverino, Daniela; Roberts, Graham; Sheikh, Aziz; Shen, Kun-Ling; Szepfalusi, Zsolt; Tsiligianni, Ioanna; Turkalj, Mirjana; Turner, Steve; Umanets, Tetiana; Valiulis, Arunas; Vijveberg, Susanne; Wang, Jiu-Yao; Winders, Tonya; Yon, Dong Keon; Yusuf, Osman M.; Zar, Heather J.
    Monitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural history review. Numerous factors that may affect disease activity and patient well-being need to be monitored: response and adherence to treatment, disease control, disease progression, comorbidities, quality of life, medication side-effects, allergen and irritant exposures, diet and more. However, the prioritization of such factors and the selection of relevant assessment tools is an unmet need. Furthermore, rapidly developing technologies promise new opportunities for closer, or even "real-time," monitoring between visits. Following an approach that included needs assessment, evidence appraisal, and Delphi consensus, the PeARL Think Tank, in collaboration with major international professional and patient organizations, has developed a set of 24 recommendations on pediatric asthma monitoring, to support healthcare professionals in decision-making and care pathway design. image
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    The role of respiratory syncytial virus‐ and rhinovirus‐induced bronchiolitis in recurrent wheeze and asthma—A systematic review and meta‐analysis
    (2022) Makrinioti, Heidi ; Hasegawa, Kohei ; Lakoumentas, John ; Xepapadaki, Paraskevi ; Tsolia, Maria ; Castro‐Rodriguez, Jose A. ; Feleszko, Wojciech ; Jartti, Tuomas ; Johnston, Sebastian L.; Bush, Andrew ; Papaevangelou, Vasiliki ; Camargo, Jr., Carlos A. ; Papadopoulos, Nikolaos G.
    Introduction Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis. RSV-induced bronchiolitis has been associated with preschool wheeze and asthma in cohort studies where the comparison groups consist of healthy infants. However, recent studies identify rhinovirus (RV)-induced bronchiolitis as a potentially stronger risk factor for recurrent wheeze and asthma. Aim This systematic review and meta-analysis aimed to compare the associations of RSV- and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma. Methods We performed a systematic search of the published literature in five databases by using a MeSH term-based algorithm. Cohort studies that enrolled infants with bronchiolitis were included. The primary outcomes were recurrent wheeze and asthma diagnosis. Wald risk ratios and odds ratios (ORs) were estimated, along with their 95% confidence intervals (CIs). Individual and summary ORs were visualized with forest plots. Results There were 38 studies included in the meta-analysis. Meta-analysis of eight studies that had data on the association between infant bronchiolitis and recurrent wheeze showed that the RV-bronchiolitis group were more likely to develop recurrent wheeze than the RSV-bronchiolitis group (OR 4.11; 95% CI 2.24-7.56). Similarly, meta-analysis of the nine studies that had data on asthma development showed that the RV-bronchiolitis group were more likely to develop asthma (OR 2.72; 95% CI 1.48-4.99). Conclusion This is the first meta-analysis that directly compares between-virus differences in the magnitude of virus-recurrent wheeze and virus-childhood asthma outcomes. RV-induced bronchiolitis was more strongly associated with the risk of developing wheeze and childhood asthma.