Browsing by Author "Fernández Verdejo, Rodrigo"

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    Axillary web syndrome among Chilean women with breast cancer : incidence and possible predisposing factors
    (2020) Ramírez Parada, Karol Lilia; Garay-Acevedo, D.; Mella Abarca, Williams Andrés; Petric Guajardo, Militza Paulina; Sánchez Rojel, César Giovanni; McNeely, M. L.; Leao-Ribeiro, I.; Fernández Verdejo, Rodrigo
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    Basal Serum Cortisol and Testosterone/Cortisol Ratio Are Related to Rate of Na+ Lost During Exercise in Elite Soccer Players
    (2019) Castro Sepúlveda, Mauricio; Cancino, Jorge; Fernández Verdejo, Rodrigo; Pérez Luco, Cristián; Jannas Vela, Sebastian; Ramírez Campillo, Rodrigo; Del Coso, Juan; Zbinden Foncea, Hermann
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    Cold-induced shivering for metabolic health
    (Springer Nature, 2024) Fernández Verdejo, Rodrigo; Galgani Fuentes, José
    This proof-of-concept study shows that 1 hour of cold exposure with shivering for 10 consecutive days improves glucose tolerance and other metabolic health outcomes in humans with overweight or obesity.
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    Contribution of brown adipose tissue to human energy metabolism
    (2019) Fernández Verdejo, Rodrigo; Marlatt, Kara L.; Ravussin, Eric; Galgani Fuentes, José
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    Direct Relationship Between Metabolic Flexibility Measured During Glucose Clamp and Prolonged Fast in Men
    (2020) Fernández Verdejo, Rodrigo; Castro Sepúlveda, Mauricio; Gutierrez-Pino, J.; Malo-Vintimilla, L.; López Fuenzalida, Antonio Eduardo; Olmos Coelho, Pablo Roberto; Santos Martín, José Luis; Galgani Fuentes, José
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    Effect of Supervised Resistance Training on Arm Volume, Quality of Life and Physical Perfomance Among Women at High Risk for Breast Cancer-Related Lymphedema: A Study Protocol for a Randomized Controlled Trial (STRONG-B)
    (Frontiers Media SA, 2022) Ramírez Parada, Karol Lilia; López Garzón, María; Sánchez Rojel, César Giovanni; Petric Guajardo, Militza Paulina; Alfaro Barra, Margarita Eugenia; Fernández Verdejo, Rodrigo; Reyes Ponce, Álvaro Renato; Merino Pereira, Gina Francesca; Cantarero Villanueva, Irene
    Objectives: To determine the preventive effects of supervised resistance training on arms volume, quality of life, physical performance, and handgrip strength in Chilean women at high risk for breast cancer-related lymphedema (BCRL) undergoing chemotherapy. Design: Randomized control trial. Participants: One hundred and six women at high risk for breast cancer-related lymphedema aged 18 to 70 years. Interventions: Participants will be randomized into two groups: [a] intervention, who will receive 12 weeks of supervised resistance training (STRONG-B) during adjuvant chemotherapy; and [b] control, who will receive education to promote lymphatic and venous return, maintain range of motion, and promote physical activity. Main Outcome Measures: The primary outcome will be arms volume measured with an optoelectric device (perometer NT1000). Secondary outcomes will be quality of life, handgrip strength, and physical performance. Primary and secondary outcomes will be measured at baseline, just after the intervention, and 3 and 6 months after. Statistical analysis will be performed following intention-to-treat and per-protocol approaches. The treatment effect will be calculated using linear mixed models. Discussion: The STRONG-B will be a tailored supervised resistance training that attempts to prevent or mitigate BCRL in a population that, due to both intrinsic and extrinsic factors, will commonly suffer from BCRL.
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    Endurance training attenuates catabolic signals Induced by TNF-[alpha] in muscle of mice
    (2016) Rodriguez, Julie; Fernández Verdejo, Rodrigo; Pierre, Nicolas; Priem, Fabian; Francaux, Marc
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    Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle
    (2018) Gnimassou, Olouyomi; Fernández Verdejo, Rodrigo; Brook, Matthew; Naslain, Damien; Balan, Estelle; Sayda, Mariwan; Cegielski, Jessica; Nielens, Henri; Decottignies, Anabelle; Demoulin, Jean-Baptiste; Smith, Kenneth; Atherton, Philip J.; Francaux, Marc; Deldicque, Louise
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    Exploring Fruit and Vegetable Waste in Homeless Shelters that Receive Surplus Donation from a Wholesale Market in Chile
    (2020) Fredes González, Carolina Paz; García, F.; Pérez, M. I.; Fernández Verdejo, Rodrigo
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    Insights on the role of putative muscle-derived factors on pancreatic beta cell function
    (2019) Mizgier Rojas, María Luisa; Fernández Verdejo, Rodrigo; Cherfan, J.; Pinget, M.; Bouzakri, K.; Galgani Fuentes, José
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    Metabolic elasticity — a new trait associated with health?
    (Nature Research, 2023) Fernández Verdejo, Rodrigo; Galgani Fuentes, José
    A recent study by Zhou and colleagues proposed that low metabolic elasticity and gene elasticity are involved in the metabolic alterations observed in ageing and obesity. Here, we discuss some of their findings to provide a viewpoint on these potential new traits associated with metabolic health.
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    Metabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity
    (2018) Fernández Verdejo, Rodrigo; Bajpeyi, Sudip; Ravussin, Eric; Galgani Fuentes, José
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    Metabolic flexibility to lipid during exercise is not associated with metabolic health outcomes in individuals without obesity
    (Nature Research, 2024) Fernández Verdejo, Rodrigo; Gutierrez-Pino, Juan; Hayes Ortiz, Thomas Emilio; Zbinden Foncea, Hermann; Cabello Verrugio, Claudio Alejandro; Valero-Breton, Mayalen; Tunon-Suarez, Mauro; Vargas-Foitzick, Ronald; Galgani Fuentes, José
    A low metabolic flexibility to lipid (MetF-lip) in skeletal muscle may promote ectopic lipid accumulation, thus inducing metabolic disturbances. We aimed to determine the association between MetF-lip in skeletal muscle and metabolic health outcomes in individuals without obesity. We also explored the association between MetF-lip and the inflammatory signaling pathway in skeletal muscle. This was a cross-sectional study in 17 individuals aged (median [IQR]) 55.4 [48.6, 58.5] years, with a BMI of 24.4 [22.6, 26.0] kg/m(2). MetF-lip was assessed as the increase in relative lipid oxidation during a single exercise session (similar to 50% VO(2)max, 2 hours), quantified as the drop in whole-body respiratory exchange ratio (Delta RER = RER at 2 hours - maximum RER attained). HOMA-IR, metabolic syndrome z-score, fat percentage, trunk-to-appendicular fat, and VO(2)max were included as metabolic health outcomes. The abundance of proteins of the inflammatory pathway was analyzed in resting muscle. Acute exercise progressively increased relative lipid oxidation (Delta RER = -0.04 [-0.08, -0.02]). MetF-lip was not associated with any metabolic health outcome but correlated inversely with p-p38(Thr180/Tyr182) in muscle. A low MetF-lip in skeletal muscle does not seem a major determinant of metabolic disturbances but associates with a partial activation of the inflammatory signaling in individuals without obesity.
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    Metabolic health and its association with lifestyle habits according to nutritional status in Chile : A cross-sectional study from the National Health Survey 2016-2017
    (2020) Fernández Verdejo, Rodrigo; Moya Osorio, José Luis; Fuentes López, Eduardo; Galgani Fuentes, José
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    Physical activity levels and preferences of patients with breast cancer receiving chemotherapy in Chile
    (2019) Ramírez Parada, Karol Lilia; Courneya, K. S.; Muniz, S.; Sánchez Rojel, César Giovanni; Fernández Verdejo, Rodrigo
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    Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals
    (2018) Cataldo Bascuñan, Luis Rodrigo; Fernández Verdejo, Rodrigo; Santos Martín, José Luis; Galgani Fuentes, José
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    Predictive equations for energy expenditure in adult humans: From resting to free-living conditions
    (WILEY, 2022) Fernández Verdejo, Rodrigo; Galgani Fuentes, José
    Humans acquire energy from the environment for survival. A central question for nutritional sciences is how much energy is required to sustain cellular work while maintaining an adequate body mass. Because human energy balance is not exempt from thermodynamic principles, the energy requirement can be approached from the energy expenditure. Conceptual and technological advances have allowed understanding of the physiological determinants of energy expenditure. Body mass, sex, and age are the main factors determining energy expenditure. These factors constitute the basis for predictive equations for resting (REE) and total (TEE) energy expenditure in healthy adults. These equations yield predictions that differ up to similar to 400 kcal/d for REE and similar to 550 kcal/d for TEE. Identifying additional factors accounting for such variability and the most valid equations appears relevant. This review used novel approaches based on mathematical modeling of REE and analyses of the data from which REE predictive equations were generated. As for TEE, R-2 and SE were considered because only a few predictive equations are available. From these analyses, Oxford's and Plucker's equations appear valid for predicting REE and TEE in adults, respectively.
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    Relationship between fat distribution and metabolic flexibility in humans
    (2021) Glaves Behrmann, Alice; Fernández Verdejo, Rodrigo; Pontificia Universidad Católica de Chile. Facultad de Medicina
    Introducción: En humanos, la masa grasa del tronco se asocia con alteraciones metabólicas, mientras que la masa grasa gluteofemoral se asocia con buena salud. Estas asociaciones pueden deberse a que estos tejidos secretan distintas adipocinas que regulan la flexibilidad metabólica (FlexMet) de otros tejidos. Sin embargo, se desconoce si la distribución de grasa se asocia con FlexMet. Nuestro objetivo fue determinar la relación entre distribución de grasa y FlexMet en humanos y sus posibles determinantes. Metodos: Recopilamos evidencia de la relación entre masa grasa segmental y FlexMet mediante una revision sistemática. Realizamos un estudio en 26 adultos sanos (61,5% mujeres, 25-64 años, índice de masa corporal entre 18,5-40,0 kg/m2. La composición corporal se midió mediante DEXA, considerando como distribución de grasa: masa grasa en brazos, piernas y tronco (ajustado por la masa grasa total, edad y sexo); además, el cociente masa grasa tronco-periferica (piernas + brazos) y cociente piernas-tronco. Los sujetos se clasificaron como “bajo” o “alto” según el valor de la mediana de cada marcador de distribución de grasa. FlexMet se midió como el cambio en el cociente respiratorio en respuesta a infusiones de glucosa e insulina (ajustado por la tasa de infusión de glucosa y el RQ inicial). Se midieron las concentraciones de TNFα y adiponectina en ayunas. Resultados: La revisión sistemática incluyó 13 estudios que midieron FlexMet y la masa grasa segmental. Diez no mostraron relación entre FlexMet y la masa grasa segmental. En el estudio en humanos, encontramos que FlexMet es más baja en los sujetos con un alto vs. bajo cociente masa grasa tronco-periférica (media [DE]: 0,063 [0,049] frente a 0,102 [0,045], respectivamente, P < 0,05). TNFα se asoció directamente con la masa grasa del tronco (Pearson r = 0,42, P = 0,03). Conclusión: La distribución de grasa operacionalizada como cociente tronco-periférica está inversamente relacionada con FlexMet, pudiendo estar involucrado la secreción central de TNFα. El deterioro de FlexMet precede el desarrollo de alteraciones metabólicas.
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    Relative lipid oxidation associates directly with mitochondrial fusion phenotype and mitochondria-sarcoplasmic reticulum interactions in human skeletal muscle
    (2020) Castro Sepúlveda, Mauricio; Jannas Vela, S.; Fernández Verdejo, Rodrigo; Ávalos Allele, D.; Tapia, G.; Villagrán, C.; Quezada Sanhueza, Nicolás; Zbinden Foncea, H.
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    Upper-Limb Disability and the Severity of Lymphedema Reduce the Quality of Life of Patients with Breast Cancer-Related Lymphedema
    (2023) Ramírez Parada, Karol Lilia; González Santos, Angela ; Riady Aleuy, Layla ; Pinto, Mauricio P.; Ibáñez Cáceres, Carolina; Merino Lara, Tomás Rodrigo; Acevedo Claros, Francisco Nicolás; Walbaum García, Benjamín Vicente; Fernández Verdejo, Rodrigo ; Sánchez Rojel, César Giovanni
    Breast cancer-related lymphedema (BCRL) is characterized by arm swelling, pain, and discomfort, reducing the quality of life (QoL) of affected individuals. BRCL is caused via the blockage or disruption of the lymphatic vessels following cancer treatments, leading to an accumulation of fluid in the affected arm. While current BCRL rehabilitation treatments seek to reduce arm swelling, our study aimed to examine the impact of both the magnitude of lymphedema (ΔVolume) and arm disability on three dimensions of QoL: social, physical, and psychological. Using the Disabilities of the Arm, Shoulder, and Hand questionnaire (DASH) and the Upper Limb Lymphedema 27 questionnaire (ULL) in a group of 30 patients, we found that the magnitude of lymphedema (ΔVolume) was associated with the social dimension of QoL (r = 0.37, p = 0.041), but not with other dimensions. On the other hand, arm disability was associated with all evaluated dimensions of QoL (social, physical, and psychological: p < 0.001, p = 0.019, and p = 0.050 (borderline), respectively). These findings suggest that BCRL rehabilitation strategies should not only aim to reduce the magnitude of lymphedema but should also seek to improve or preserve arm functionality to enhance the QoL of BCRL patients.