Browsing by Author "Gago Arias, Araceli"
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- ItemA convolution model for obtaining the response of an ionization chamber in static non standard fields(2012) González-Castaño, Diego M.; Brualla González, L.; Gago Arias, Araceli; Pardo-Montero, Juan; Gómez, Faustino; Luna-Vega, Víctor; Sánchez- Garcia, Manuel; Lobato, R.
- ItemA dynamic nonlinear coupled differential equations model of tumor growth and response to radiotherapy(2018) Ortiz Guzmán, Valentina; Gago Arias, Araceli; Espinoza Bornscheuer, Ignacio Guillermo; Karger, Christian; Pontificia Universidad Católica de Chile. Facultad de Física
- ItemA Model of Indirect Cell Death Caused by Tumor Vascular Damage after High-Dose Radiotherapy(2019) Rodriguez-Barbeito, P.; Diaz-Botana, P.; Gago Arias, Araceli; Feijoo, M.; Neira, S.; Guiu-Souto, J.; Lopez-Pouso, O.; Gomez-Caamano, A.; Pardo-Montero, J.
- ItemAnalysis of ionic mobilities in liquid isooctane with low dose radiotherapy pulsed photon beams(2012) Pardo-Montero, J.; Tegami, S.; Gago Arias, Araceli; González-Castaño, D.M.; Holzscheiter, M.H.; Gómez, F.
- ItemCorrection factors for A1SL ionization chamber dosimetry in TomoTherapy: Machine-specific, plan-class, and clinical fields(2012) Gago Arias, Araceli; Rodríguez-Romero, Ruth; Sánchez-Rubio, Patricia; González-Castaño, Diego Miguel; Gómez, Faustino; Núñez, Luis; Palmans, Hugo; Sharpe, Peter; Pardo-Montero, Juan
- ItemDesarrollo e implementación de un sistema de auditoría para dosimetría absoluta con alanina y TLD en centros de radioterapia chilenos(2018) Faúndez Cifuentes, Daniel; Gago Arias, Araceli; Pontificia Universidad Católica de Chile. Facultad de Física
- ItemDevelopment of an alanine dosimetry system for radiation dose measurements in the radiotherapy range(2015) Gago Arias, Araceli; Gonzalez Castaño, D. M.; Gomez, F.; Peteiro, E.; Lodeiro, C.; Pardo Montero, J.
- ItemE-IMRT: A web platform for the verification and optimization of radiation treatment plans(2009) Pena, J.; Gonzalez-Castaño, D.M.; Gomez, F.; Gago Arias, Araceli; González-Castaño, F.J.; Rodríguez-Silva, D.A.; González, D.; Pombar, M.; Sánchez, M.; Portas, B.C.; Gómez, A.; Mouriño, C.
- ItemeIMRT: A web platform for the verification and optimization of radiation treatment plans(2009) Pena, J.; González-Castaño, D.M.; Gómez, F.; Gago Arias, Araceli; González-Castaño, F.J.; Rodríguez-Silva, D.; Gómez, A.; Mouriño, C.; Pombar, M.; Sánchez, M.
- ItemEvaluation of chamber response function influence on IMRT verification using 2D commercial detector arrays(2012) Gago Arias, Araceli; Brualla-González, L.; González-Castaño, D.M.; Gómez, F.; García, M.S.; Vega, V.L.; Sueiro, J.M.,; Pardo-Montero, J.
- ItemImpact of different biologically-adapted radiotherapy strategies on tumor control evaluated with a tumor response model(2018) Gago Arias, Araceli; Sánchez Nieto, Beatriz; Espinoza Bornscheuer, Ignacio Guillermo; Christian P. Karger,; Pardo-Montero, Juan
- ItemIncorporación de PET/CT en un modelo para predicción de respuesta tumoral a la radioterapia(2021) Casanova Granada, Ángela Verónica; Sánchez Nieto, Beatriz; Gago Arias, Araceli; Pontificia Universidad Católica de Chile. Facultad de FísicaEn el presente proyecto de tesis se utilizaron valores de captación de imágenes FDG-PET obtenidos en distintos subvolúmenes de tumores de cabeza y cuello para asociarlos con distintos niveles de radiosensibilidad. Esta relación se estableció utilizando información sobre la ganancia en niveles de control tumoral obtenida con tratamientos de dose painting frente a tratamiento convencionales (información reportada por los oncólogos radioterapeutas que trabajaron en el proyecto FiGaRo). La radiosensibilidad efectiva de cada subvolumen fue incorporada a un modelo radiobiológico que analiza el efecto en la probabilidad de control tumoral de la distribución de dosis. También la información de los valores de captación del 18F-FDG obtenida de las imágenes PET, permitió realizar una nueva segmentación del volumen GTVPET (volumen segmentado manualmente por el médico especialista a partir de las imágenes PET) con el fin de analizar el impacto que tendría este nuevo volumen en los valores de probabilidad de control tumoral.
- ItemSimulation of hypoxia PET-tracer uptake in tumours : Dependence of clinical uptake-values on transport parameters and arterial input function(2020) Paredes Cisneros, I.; Karger, C. P.; Caprile Etchart, Paola F.; Nolte, D.; Espinoza Bornscheuer, Ignacio Guillermo; Gago Arias, Araceli
- ItemSimulation of oxygen and hypoxia PET-tracer distributions in 3D vascular architectures of tumours(2018) Isabela Paredes Cisneros; Karger, Christian; Gago Arias, Araceli; Pontificia Universidad Católica de Chile. Facultad de FísicaThe outcome of radiotherapy is strongly influenced by hypoxia (low level of oxygenin the tumour), which leads to increased radioresistance and poor outcome. Positron Emission Tomography (PET) can be used to identify hypoxic regions within tumours. Hypoxia-specific tracers have been developed for this purpose. Deriving the tumour oxygen distribution from a hypoxia PET-tracer distribution is still not straightforward and computer simulations may help to better understand the limitations of this technique. In this thesis, hypoxia PET-tracer distributions were simulated in three dimensions by using mathematical models to calculate the spatiotemporal distributions of both oxygen and tracer in the tumour. The impact of necrosis in the tracer uptake was also considered. The partial differential equations in the model were solved, using the Finite Element Method for different vascular architectures. The correct functioning of the solving method was checked for simple architectures by changing parameter values and analysing the obtained distributions. Time-Activity Curves were calculated from the simulated concentrations and the impact of the vascular fraction was determined, for vascular architectures of different complexity. This study improves the understanding of the signal in hypoxia-PET studies. Future work should take into account even more complex vascular architectures, as well as acute hypoxia.