Browsing by Author "Garayar, B"

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    Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery
    (ARNOLD, HODDER HEADLINE PLC, 2000) Moran, SV; Lema, G; Medel, J; Irarrazaval, MJ; Zalaquett, R; Garayar, B; Flaskamp, R
    This study was designed to evaluate efficacy and tolerability of two different doses of aprotinin in patients receiving aspirin before undergoing coronary artery bypass grafting. Forty-two patients were randomized to receive either placebo (group I), or aprotinin in doses of 4 000 000 KIU (group II) or 6 000 000 KIU (group III). Drug efficacy was determined by measuring postoperative blood loss and transfusion of blood products. Both doses were effective in reducing blood loss and transfusion requirements. Blood loss through thoracotomy drainage was 450 +/- 224, 182 +/- 144, 142 +/- 98 mi, respectively, for control and treatment groups II and III (p = 0.0001). The numbers of patients with blood transfusions were seven (50%), two (17%) and two (17%) for group I and treatment groups II and ill, respectively (p = 0.10). Tolerability was excellent and complications few and reversible.