Browsing by Author "Garcia P."

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    ECOPHAGE: Combating Antimicrobial Resistance Using Bacteriophages for Eco-Sustainable Agriculture and Food Systems
    (Multidisciplinary Digital Publishing Institute (MDPI), 2023) Garcia P.; Tabla R.; Anany H.; Bastias R.; Brondsted L.; Casado S.; Cifuentes P.; Deaton J.; Denes T.G.; Islam M.A.; Lavigne R.; Moreno-Switt A.I.; Nakayama N.; Munoz Madero C.; Sulakvelidze A.; Svircev A.M.; Wagemans J.; Biosca E.G.; Rivera D.
    © 2023 by the authors.The focus of this meeting was to discuss the suitability of using bacteriophages as alternative antimicrobials in the agrifood sector. Following a One Health approach, the workshop explored the possibilities of implementing phage application strategies in the agriculture, animal husbandry, aquaculture, and food production sectors. Therefore, the meeting had gathered phage researchers, representatives of the agrifood industry, and policymakers to debate the advantages and potential shortcomings of using bacteriophages as alternatives to traditional antimicrobials and chemical pesticides. Industry delegates showed the latest objectives and demands from consumers. Representatives of regulatory agencies (European Medicines Agency (EMA) and Spanish Agency of Medicines and Health Products (AEMPS)) presented an update of new regulatory aspects that will impact and support the approval and implementation of phage application strategies across the different sectors.
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    Prognostic factors in de novo metastatic renal cell carcinoma: A report from the latin american renal cancer group
    (American Society of Clinical Oncology, 2021) Abreu D.; Decia R.; Carvalhal G.; Gueglio G.; Tobia I.; Garcia P.; Zuñiga A.; Meza L.; Bengio R.; Scorticati C.; Castillejos R.; Rodriguez F.; Autran A.M.; Gonzales C.; Gadu J.; Nolazco A.; Ameri C.; Zampolli H.; Langenhin R.; Muguruza D.; Machado M.T.; Mingote P.; Yandian J.; Clavijo J.; Nogueira L.; Clark O.; Secin F.; Rovegno A.; Vilas A.; Barrios E.; Guimarães G.; Zequi S.C.; Glina S.; Pal S.K.; Rodriguez O.; Palou J.; Spiess P.; Lara P.N.; Marston Linehan W.; Pastore A.L.
    © 2021 by American Society of Clinical Oncology.PURPOSE To assess the effect of clinical and pathological variables on cancer-specific and overall survival (OS) in de novo metastatic patients from a collaborative of primarily Latin American countries. PATIENTS AND METHODS Of 4,060 patients with renal cell carcinoma diagnosed between 1990 and 2015, a total of 530 (14.5%) had metastasis at clinical presentation. Relationships between clinical and pathological parameters and treatment-related outcomes were analyzed by Cox regression and the log-rank method. RESULTS Of 530 patients, 184 (90.6%) had died of renal cell carcinoma. The median OS of the entire cohort was 24 months. American Society of Anesthesiology classification 3-4 (hazard ratio [HR]: 1.64), perirenal fat invasion (HR: 2.02), and ≥ 2 metastatic organ sites (HR: 2.19) were independent prognostic factors for 5-year OS in multivariable analyses. We created a risk group stratification with these variables: no adverse risk factors (favorable group), median OS not reached; one adverse factor (intermediate group), median OS 33 months (HR: 2.04); and two or three adverse factors (poor risk group), median OS 14 months (HR: 3.58). CONCLUSION Our study defines novel prognostic factors that are relevant to a Latin American cohort. With external validation, these easily discerned clinical variables can be used to offer prognostic information across low- and middle-income countries.