Browsing by Author "Godoy, Juan A."
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- ItemAge Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease(2015) Inestrosa Cantín, Nibaldo; Rios, Juvenal A.; Cisternas, Pedro; Tapia Rojas, Cheril Cecilia; Rivera, Daniela S.; Braidy, Nady; Zolezzi, Juan M.; Godoy, Juan A.; Carvajal Cachaña, Francisco Javier; Ardiles, Alvaro O.
- ItemAmyloid-B-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the AB peptide. Implications for the pathogenesis of Alzheimer's disease(2010) Dinamarca Ceballos, Margarita Constanza.; Sagal, Juan P.; Quintanilla Gómez, Rodrigo Arthur; Godoy, Juan A.; Arrázola, Macarena S; Inestrosa Cantín, NibaldoAbstract The presence of amyloid-β (Aβ) deposits in selected brain regions is a hallmark of Alzheimer's disease (AD). The amyloid deposits have "chaperone molecules" which play critical roles in amyloid formation and toxicity. We report here that treatment of rat hippocampal neurons with Aβ-acetylcholinesterase (Aβ-AChE) complexes induced neurite network dystrophia and apoptosis. Moreover, the Aβ-AChE complexes induced a sustained increase in intracellular Ca2+ as well as a loss of mitochondrial membrane potential. The Aβ-AChE oligomers complex also induced higher alteration of Ca2+ homeostasis compared with Aβ-AChE fibrillar complexes. These alterations in calcium homeostasis were reversed when the neurons were treated previously with lithium, a GSK-3β inhibitor; Wnt-7a ligand, an activator for Wnt Pathway; and an N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801), demonstrating protective roles for activation of the Wnt signaling pathway as well as for NMDA-receptor inhibition. Our results indicate that the Aβ-AChE complexes enhance Aβ-dependent deregulation of intracellular Ca2+ as well as mitochondrial dysfunction in hippocampal neurons, triggering an enhanced damage than Aβ alone. From a therapeutic point of view, activation of the Wnt signaling pathway, as well as NMDAR inhibition may be important factors to protect neurons under Aβ-AChE attack.
- ItemAmyloid-beta Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity(2016) Guivernau, Biuse; Bonet, Jaume; Valls Comamala, Victoria; Bosch Morato, Mónica; Godoy, Juan A.; Inestrosa Cantín, Nibaldo
- ItemPPARs in the central nervous system: roles in neurodegeneration and neuroinflammation(2017) Zolezzi, Juan M.; Santos Alcántara, Manuel; Bastías Candia, Sussy; Pinto, Claudio; Godoy, Juan A.; Inestrosa Cantín, Nibaldo
- ItemQuercetin Exerts Differential Neuroprotective Effects Against H2O2 and A beta Aggregates in Hippocampal Neurons: the Role of Mitochondria(2017) Godoy, Juan A.; Lindsay, Carolina B.; Quintanilla, Rodrigo A.; Carvajal Cachaña, Francisco Javier; Cerpa Nebott, Waldo Francisco; Inestrosa Cantín, Nibaldo
- ItemThe soluble extracellular fragment of neuroligin-1 targets Aβ oligomers to the postsynaptic region of excitatory synapses(2015) Dinamarca, Margarita C.; Di Luca, Mónica; Godoy, Juan A.; Inestrosa Cantín, Nibaldo
- ItemWnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production(2015) Parodi, Jorge; Montecinos Oliva, Carla; Varas, Rodrigo; Alfaro, Iván E.; Serrano, Felipe G.; Varas Godoy, Manuel; Muñoz, Francisco J.; Cerpa Nebott, Waldo Francisco; Godoy, Juan A.; Inestrosa Cantín, Nibaldo