Browsing by Author "González, Claudia"

Now showing 1 - 8 of 8
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    Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples
    (2008) Ferreccio Readi, Catterina; Corvalán R., Alejandro; Margozzini Maira, Paula; Viviani García, Paola; González, Claudia; Aguilera, Ximena; Gravitt, Patti E
    Abstract Background Chile has broad variations in weather, economics and population from the far desert north (Region 1) to the cold, icy south (Region 12). A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus Methods The population was a national probability sample of people 17 years of age and over. Consenting women provided self-collected cervicovaginal swabs in universal collection media (UCM). DNA was extracted and typed to 37 HPV genotypes using PGMY consensus PCR and line blot assay. Weighted prevalence rates and adjusted OR were calculated. Results Of the 1,883 women participating in the health survey, 1,219 (64.7%) provided a cervicovaginal sample and in 1,110 (56.2% of participants and 66.5% of those eligible) the samples were adequate for analysis. Refusal rate was 16.9%. HPV prevalence was 29.2% (15.1% high-risk HPV and 14.1% low-risk HPV). Predominant high-risk types were HPV 16, 52, 51, 56 and 58. Predominant low-risk HPVs were HPV 84, CP6108, 62, 53 and 61. High-risk and low-risk HPV rates were inversely correlated between the regions. High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age. Conclusion Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.
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    Case-Control Study of Risk Factors for Meningococcal Disease in Chile
    (2017) Olea, Andrea; Matute, Isabel; González, Claudia; Delgado, Iris; Poffald, Lucy; Pedroni, Elena; Alfaro, Tania; Hirmas, Macarena; Nájera, Manuel; Ferreccio Readi, Catterina; Gormaz, Ana; López, Darío; Loayza, Sergio; Gallegos, Doris; Fuentes, Rodrigo; Vial, Pablo; Aguilera, Ximena
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    Determination of variables for a more accurate diagnostic approach in suspected acute invasive fungal rhinosinusitis: A non-concurrent cohort study
    (2021) Lagos Villaseca, Antonia Elisa; García-Huidobro Núñez, Francisco Gustavo; Valeria Sepúlveda; Cruz, Juan Pablo; González, Claudia; Callejas Cánepa, Claudio Andrés
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    Epithelial Cell Culture from Human Adenoids : A Functional Study Model for Ciliated and Secretory Cells
    (2013) González, Claudia; Espinosa de la Fuente, Marisol; Sánchez Dueñas, María Trinidad; Droguett, Karla; Ríos Raggio, Mariana; Fonseca Arrieta, María Ximena; Villalón, Manuel J.
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    Long-lasting neutralizing antibody responses in SARS-CoV-2 seropositive individuals are robustly boosted by immunization with the CoronaVac and BNT162b2 vaccines
    (2021) Muena, Nicolás A.; García Salum, Tamara Cristal; Pardo Roa, Catalina; Serrano García, Eileen Francisca; Levicán Asenjo, Jorge Enrique; Avendaño, María José; Almonacid Cárdenas, Leonardo Iván; Valenzuela Galaz, Gonzalo Hernán; Poblete Cárdenas, Estefany Aracely; Strohmeier, Shirin; Salinas Ortíz, Erick David; Haslwanter, Denise; Dieterle, Maria Eugenia; Jangra, Rohit K.; Chandran, Kartik; González, Claudia; Riquelme Pérez, Arnoldo Javier; Krammer, Florian; Tischler, Nicole D.; Medina, Rafael
    The durability of circulating neutralizing antibody (nAb) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their boosting by vaccination remains to be defined. We show that outpatient and hospitalized SARS-CoV-2 seropositive individuals mount a robust neutralizing antibody (nAb) response that peaks at days 23 and 27 post-symptom onset, respectively. Although nAb titers remained higher in hospitalized patients, both study groups showed long-lasting nAb responses that can persist for up to 12 months after natural infection. These nAb responses in previously seropositive individuals can be significantly boosted through immunization with two doses of the CoronaVac (Sinovac) or one dose of the BNT162b2 (BioNTech/Pfizer) vaccines, suggesting a substantial induction of B cell memory responses. Noteworthy, three obese previously seropositive individuals failed to mount a booster response upon vaccination, warranting further studies in this population. Immunization of naïve individuals with two doses of the CoronaVac vaccine or one dose of the BNT162b2 vaccine elicited similar levels of nAbs compared to seropositive individuals 4.2 to 13.3 months post-infection with SARS-CoV-2. Thus, this preliminary evidence suggests that both, seropositive and naïve individuals, require two doses of CoronaVac to ensure the induction of robust nAb titers.
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    Lung cancer and arsenic concentrations in drinking water in Chile
    (LIPPINCOTT WILLIAMS & WILKINS, 2000) Ferreccio Readi, Catterina; González, Claudia; Milosavjlevic, Vivian; Marshall Rivera, Guillermo; Sancha, Ana María; Smith, Allan H.
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    Otolaryngology residency strategies during the COVID-19 pandemic
    (2020) Alvarez Baeza, Matías Lautaro; Lagos Villaseca, Antonia Elisa; Sepúlveda Carrasco, Valeria Katalina; Napolitano Valenzuela, Carla Andrea; González, Claudia
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    TNFα Affects Ciliary Beat Response to Increased Viscosity in Human Pediatric Airway Epithelium
    (2016) González, Claudia; Droguett, Karla; Ríos, Mariana; Cohen, Noam A.; Villalón, Manuel J.