Browsing by Author "González Díaz, Hernán"

Now showing 1 - 12 of 12
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    Concordancia de la citología por punción con aguja fina para la detección de cáncer de tiroides en pediatría
    (2014) Grob Lunecke, Francisca Andrea; Carrillo, D.; Martínez Aguayo, Alejandro Gregorio; Zoroquiain Vélez, José Pablo; Solar González, Antonieta Alejandra; Nicolaides, I.; González Díaz, Hernán
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    Cuándo y cómo realizar una biopsia de las lesiones cutáneas frecuentes. Lo que el cirujano debe saber
    (2015) Droppelmann Droppelmann, Katherine Ann; Cataldo C., Karina; Molgó Novell, Montserrat; Goñi Espíldora, Ignacio; León Ramírez, Augusto; Camus Appuhn, Mauricio Gonzalo; González Díaz, Hernán; Domínguez Covarrubias, Francisco José; Droppelmann, Nicolás
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    Del macro al microcarcinoma tiroideo : cambios en las características de presentación del cáncer de tiroides en un centro universitario chileno en 20 años
    (2013) Mosso Gómez, Lorena; Campusano Montaño, Claudia; González Díaz, Hernán; Domínguez Ruiz-Tagle, José Miguel; Salman, Patricio; Suazo, Valeria; Solar González, Antonieta Alejandra; Cerda, Jaime
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    Estudio y manejo de nódulos tiroideos por médicos no especialistas. Consenso SOCHED
    (2017) Tala, Hernán; Díaz, René E.; Domínguez Ruiz-Tagle, José Miguel; Sapunar Zenteno, Jorge; Pineda, Pedro; Mosso Gómez, Lorena; González Díaz, Hernán; Grob Lunecke, Francisca Andrea; Cruz Olivos, Francisco; Solar González, Antonieta Alejandra; Gac, Patricio E.; Glasinovic Pizarro, Andrea; Barberán, Marcela; Cabané, Patricio; Hidalgo Valle, Maria Soledad; Jaimovich, Rodrigo; Lanas, Alejandra; Liberman, Claudio; Lobo Guiñez, Maite; Madrid, Arturo; Moreno Seguel, Marcela; Arroyo Albala, Patricia; Munizaga, Fernando C.; Ortiz Parada, Eugenia; Osorio Gonnet, Fernando; Slater Morales, Jeannie; Stehr, Carlos; Vásquez Rodríguez, Félix; Véliz, Jesús; Villaseca Najarian, Roberto; Wohllk, Nelson
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    Genetic testing for indeterminate thyroid cytology: review and meta-analysis.
    (2018) Vargas Salas, Sergio; Martinez, Jose R.; Urra, Soledad; Domínguez Ruiz-Tagle, José Miguel; Mena, Natalia; Uslar, Thomas; Lagos Lucero, Marcela; Henríquez Henríquez, Marcela Patricia; González Díaz, Hernán
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    Hiperparatiroidismo primario : manejo quirúrgico
    (2014) Pulgar, D.; Jans, J.; D'Aguzan, N.; León Ramírez, Augusto; Goñi Espíldora, Ignacio; González Vicente, Gilberto; González Díaz, Hernán
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    Medullary thyroid cancer. Review of 28 patients
    (2013) Pulgar, D.; Jans, J.; Petric, M.; León Ramírez, Augusto; Camus Appuhn, Mauricio Gonzalo; Goñi Espíldora, Ignacio; Domínguez Covarrubias, Francisco José; Droppelmann, Nicolás; González Díaz, Hernán; Claure Saavedra, Raúl
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    Neck Sonography and Suppressed Thyroglobulin Have High Sensitivity for Identifying Recurrent/Persistent Disease in Patients With Low-risk Thyroid Cancer Treated With Total Thyroidectomy and Radioactive Iodine Ablation, Making Stimulated Thyroglobulin Unne
    (2017) Domínguez Ruiz-Tagle, José Miguel; Nilo, Flavia; Contreras, T.; Carmona, R.; Droppelmann, Nicolás; González Díaz, Hernán; Iturrieta, V.; Tuttle, R.
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    Nuevas terapias sistémicas para el tratamiento del melanoma
    (2016) Droppelmann, Nicolás; León Ramírez, Augusto; Goñi Espíldora, Ignacio; González Díaz, Hernán; Domínguez Covarrubias, Francisco José; Camus Appuhn, Mauricio Gonzalo; Nervi Nattero, Bruno; Uribe González, Pablo Francisco; Molgó Novell, Montserrat; Acevedo Claros, Francisco Nicolás
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    Papillary thyroid microcarcinoma: characteristics at presentation, and evaluation of clinical and histological features associated with a worse prognosis in a Latin American cohort
    (2018) Domínguez Ruiz-Tagle, José Miguel; Nilo, Flavia; Martinez, Maria T.; Massardo, Jose M.; Munoz, Sueli; Contreras, Tania; Carmona, Rocio; Jerez, Joaquin; González Díaz, Hernán; Droppelmann, Nicolás; León Ramírez, Augusto
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    The role of VEGF-R3 pathway switch induced by M2-like tumour associated macrophages on the development of a pro-metastatic phenotype in papillary thyroid carcinoma
    (2020) Vargas Salas, Sergio; González Díaz, Hernán; Pontificia Universidad Católica de Chile. Escuela de Medicina
    Cancer is the second leading cause of death globally. The major determinant of mortality in cancer patients is the presence of distant organ metastasis, and one of the most important clinical risk factors is the compromise of locoregional lymph nodes by cancer cells (lymph nodes metastasis or LNM). The pathogenesis of LNM includes many processes, and one of the main focuses of translational research in oncology has been the understanding of the biological mechanisms underlying those processes to develop novel diagnostic, prognostic and therapeutic clinical tools. Among solid tumours, Papillary Thyroid Cancer (PTC) is an excellent model to study early events in LNM development, mainly due to three arguments: a significant number of samples can be potentially studied in a wide spectrum of the disease, from non-metastatic to widely invasive tumours; PTC is a well-differentiated tumour, so being possible to study early events in the cell transformation from a non-metastatic to a pro-metastatic phenotype; and PTC spreading occurs by lymphatic system in 95% of metastatic cases. Previous background suggests that VEGF-R3/VEGF-C system could be an important signalling pathway by which epithelial tumours could develop a pro-metastatic architecture, not only by inducing the development of lymphatic vessels, but also by promoting the transformation of tumour epithelial cells to a pro-metastatic phenotype. Furthermore, M2-like tumour associated macrophages (M2-TAMs) seem to be key players in the pro-metastatic transformation as well. However, no previous studies have provided evidence suggesting that both, M2-TAMs and the VEGF-R3 pro-metastatic switch, could be associated. From prior results of our group, we postulate that, in PTC, M2-TAMs induce a VEGF-R3 pro-metastatic switch at the epithelial tumour cell, promoting the transformation toward a pro-metastatic phenotype. This work takes over two emerging questions aimed to confirm this hypothesis: which TAM subtype (M1-like or M2-like cells) induce a VEGF-R3 pro-metastatic switch in PTC?, and does the VEGF-R3 pro-metastatic switch activate biological mechanisms that lead to a pro-metastatic phenotype in epithelial tumour cells? Our results showed that conditioned medium from M2-TAM induces the overexpression of VEGF-R3 in TPC-1 (a non-metastatic PTC cell model) but not in B-CPAP (a metastatic PTC cell model), which suggest that the switch is a pre-metastatic event. Furthermore, the receptor is functionally active when cells are treated with VEGF-C (the specific ligand of VEGF-R3), inducing pro-metastatic morphological changes, the overexpression of genomic regulator of epithelial-to-mesenchymal transition, and increasing the cell migration capability. Taken together, these results support our working hypothesis; however, further studies are required to better understand the real meaning of this signalling pathway in the LNM development, as well as to determine the mechanisms by which M2-TAMs could induce the switch. We expect that this work can help, in the future, to a better understanding of the mechanisms underlying the LNM development process in PTC, with potential applications in other solid tumours. Ultimately, this could be useful to generate important advances in diagnostic, prognostic and therapeutic tools, with potential impact in thousands of patients with cancer.
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    Tratamiento quirúrgico del hiperparatiroidismo asociado a insuficiencia renal crónica
    (2015) Pulgar B., Dahiana; Jara Contreras, Aquiles; González Vicente, Gilberto; González Díaz, Hernán