Browsing by Author "Gonzalez, MF"

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    Epoxidation of quinones with urea hydrogen peroxide
    (PERGAMON-ELSEVIER SCIENCE LTD, 2003) Valderrama, JA; Gonzalez, MF; Torres, C
    Quinones reacted with urea-hydrogen peroxide complex in the presence of a base at room temperature, to give the corresponding quinone epoxides in 22-92% yields. The advantages of this new quinone epoxidation procedure are the requirement of organic solvent media, a easily handled solid reagent and a simple workup procedure.
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    Studies on quinones. Part 32. Regioselective synthesis of benz[b]phenantridines related to phenantroviridone
    (PERGAMON-ELSEVIER SCIENCE LTD, 1999) Valderrama, JA; Gonzalez, MF; Valderrama, C
    The Diels-Alder reaction of juglone (4) and bromojuglone 18 with 1-cyclohesenecarbosaldehyde dimethylhydrazone (3) is described. Through these cycloaddition reactions 8-hydroxy-1,2,3,4-tetrahydrobenz[b]phenantridin-7,12-dione (5) was obtained in 55 and 78% yield, respectively. Oxidation of 5 to 8-hydroxybenz[b]phenantridin-7,12-dione (6) and 8-hydroxy-1,2,3,4-tetrahydrobenz[b]phenantridin-1,7,12-trione (15) is also reported. (C) 1999 Elsevier Science Ltd. All rights reserved.
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    Studies on quinones. Part 39: Synthesis and leishmanicidal activity of acylchloroquinones and hydroquinones
    (PERGAMON-ELSEVIER SCIENCE LTD, 2005) Valderrama, JA; Zamorano, C; Gonzalez, MF; Prina, E; Fournet, A
    Acylhydroquinone-based compounds are attractive targets for the design of new leishmanicidal drugs. We have previously described sesquiterpene quinones and hydroquinones series, which exhibit different degree of potency against Leishmania amazonensis. The present study details the preparation of acylchloroquinones and hydroquinones possessing lipophilic substituents and examines their in vitro activity against intracellular L. amazonensis amastigotes. The quinone or hydroquinone nucleus is essential for the activity of the members of the series. The lipophilicity of the cycloaliphatic systems in these members seems to attenuate the cytotoxical effect and increases the selectivity of those compounds containing the norbornene system. (c) 2005 Elsevier Ltd. All rights reserved.