Browsing by Author "Han, MeiLan K."

Now showing 1 - 3 of 3
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    Association Between Airway Caliber Changes With Lung inflation and Emphysema Assessed by Volumetric CT Scan in Subjects With COPD
    (2012) Diaz, Alejandro A.; Come, Carolyn E.; Ross, James C.; Estepar, Raul San Jose; Han, MeiLan K.; Loring, Stephen H.; Silverman, Edwin K.; Washko, George R.
    Background: An increase in airway caliber (airway distensibility) with lung inflation is attenuated in COPD. Furthermore, some subjects have a decrease in airway caliber with lung inflation. We aimed to test the hypothesis that airway caliber increases are lower in subjects with emphysema-predominant (EP) compared with airway-predominant (AP) CT scan subtypes. Additionally, we compared clinical and CT scan features of subjects with (airway constrictors) and without a decrease in airway caliber.
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    Physiological and Computed Tomographic Predictors of Outcome from Lung Volume Reduction Surgery
    (AMER THORACIC SOC, 2010) Washko, George R.; Martinez, Fernando J.; Hoffman, Eric A.; Loring, Stephen H.; Estepar, Raul San Jose; Diaz, Alejandro A.; Sciurba, Frank C.; Silverman, Edwin K.; Han, MeiLan K.; DeCamp, Malcolm; Reilly, John J.; Natl Emphysema Treatment Trial Res
    Rationale: Previous investigations have identified several potential predictors of outcomes from lung volume reduction surgery (LVRS). A concern regarding these studies has been their small sample size, which may limit generalizability. We therefore sought to examine radiographic and physiologic predictors of surgical outcomes in a large, multicenter clinical investigation, the National Emphysema Treatment Trial.
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    Statins and Pulmonary Fibrosis The Potential Role of NLRP3 Inflammasome Activation
    (2012) Xu, Jin-Fu; Washko, George R.; Nakahira, Kiichi; Hatabu, Hiroto; Patel, Avignat S.; Fernandez, Isis E.; Nishino, Mizuki; Okajima, Yuka; Yamashiro, Tsuneo; Ross, James C.; Estepar, Raul San Jose; Diaz, Alejandro A.; Li, Hui-Ping; Qu, Jie-Ming; Himes, Blanca E.; Come, Carolyn E.; D'Aco, Katherine; Martinez, Fernando J.; Han, MeiLan K.; Lynch, David A.; Crapo, James D.; Morse, Danielle; Ryter, Stefan W.; Silverman, Edwin K.; Rosas, Ivan O.; Choi, Augustine M. K.; Hunninghake, Gary M.
    Rationale: The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in the development or progression of interstitial lung disease (ILD) is controversial.