Browsing by Author "Huidobro, Andrea"

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    Gestational diabetes, comparison of women diagnosed in second and third trimester of pregnancy with non GDM women: Analysis of a cohort study
    (SOC MEDICA SANTIAGO, 2010) Huidobro, Andrea; Prentice, Andrew; Fulford, Tony; Parodi, Carmen; Rozowski, Jaime
    Pregnant women are normally screened for Gestational diabetes (GDM) at week 24 of pregnancy. However sonic women develop the disease later on their pregnancies. No study has analyzed women developing GDM later in pregnancy Objective: To analyze data on a cohort study and compare women diagnosed with GDM in second and third trimester of pregnancy with women without GDM Results: GDM women diagnosed during their first two trimesters of pregnancy were older (p = 0.0008) and had higher body mass index (BMI) (p = 0.0007) than non GDM women. However, the only risk factor in women diagnosed in their third trimester of pregnancy was having first degree relatives with type 2 DM and this was independent of age and BMI (OR of 2 7, 95% CI 1.2 - 6 0) Conclusions: Women who develop GDM in their second trimester of pregnancy have known risk factors for diabetes mellitus such as age and higher BM!, however, the only recognised risk factor between non GDM women and women developing GDM late in pregnancy is family history of type 2 DM Two populations of GDM may exist and future studies should focus on analysing short and long term complications of these women to support the need to diagnosed and treat them all. (Rev Med Chile 2010; 138: 316-321).
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    Processed meat eater profile in a Latin-American cohort
    (2020) Ruedlinger, Jenny; Paredes, F.; Cid, V.; Huidobro, Andrea; Ferreccio, Catterina
    Background: We aim to describe the prevalence, distribution and factors associated to processed meat (e.g. sausages, bacon) consumption (PMC) in a Chilean population-based cohort. This is the first study to explore this exposure in Chile. Methods: We studied 7841 participants of the Maule Cohort, 4358 women, 3483 men aged 37 to 77 years, who answered an epidemiological survey (diet, alcohol, health, socioeconomic), had a medical examination, and provided fasting blood. We stratified them in five groups by weekly frequency of PMC from (1) none, (2) <1/week, (3) 1/week, (4) 2-4/week to (5) >5/week. We analyzed MAUCO cohort baseline data in association with PMC. We estimated Prevalence ratios (PR) with Poisson regression (age, schooling & sex adjusted) and with multinomial logistic regression we modelled PMC using group 1 as reference. Results: High consumers were 8% (7% women, 9% men). Binge drinking was more common among participants in groups 2, 3 & 4 (Relative Risk Ratio, RRR) 1.26, 95% confidence interval (CI) 1.04-1.52; 1.28, CI 1.0-1.55 & 1.32, CI 1.08-1.6). As for diet, participants consuming red meat (>4 /week, 2.79; CI 2.13-3.66), butter/cream (>4 times/week, 2.07; CI 1.62-2.64), sugary snacks/sweets (≥1 time/day, 2.26; 1.81-2.83) and sugary drinks (≥1 time/day, 1.85; CI 1.48-2.31) were more likely to be in the high PMC group. Cardiovascular diseases (1.72, 1.17-2.52) and large waist circumference (1.01, 1.0 - 1.02) were more common in participants in the high PMC group. Conclusions: High consumption of processed meat is accompanied by other behaviors and risk factors that can potentiate adverse health effects in this population. Key messages: In Chile, little attention has been given to potential health impacts of processed meat. This work aims to bring focus to this issue. High processed meat consumption was associated with other non-healthy foods, risky alcohol intake and unhealthy weight, all of which can increase the risk of chronic diseases.
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    The Association between Fasting Glucose and Sugar Sweetened Beverages Intake Is Greater in Latin Americans with a High Polygenic Risk Score for Type 2 Diabetes Mellitus
    (2022) Lopez-Portillo, Maria Lourdes; Huidobro, Andrea; Tobar-Calfucoy, Eduardo; Yanez, Cristian; Retamales-Ortega, Rocio; Garrido-Tapia, Macarena; Acevedo, Johanna; Paredes, Fabio; Cid-Ossandon, Vicente; Ferreccio, Catterina; Verdugo, Ricardo A.
    Chile is one of the largest consumers of sugar-sweetened beverages (SSB) world-wide. However, it is unknown whether the effects from this highly industrialized food will mimic those reported in industrialized countries or whether they will be modified by local lifestyle or population genetics. Our goal is to evaluate the interaction effect between SSB intake and T2D susceptibility on fasting glucose. We calculated a weighted genetic risk score (GRSw) based on 16 T2D risk SNPs in 2828 non-diabetic participants of the MAUCO cohort. SSB intake was categorized in four levels using a food frequency questionnaire. Log-fasting glucose was regressed on SSB and GRSw tertiles while accounting for socio-demography, lifestyle, obesity, and Amerindian ancestry. Fasting glucose increased systematically per unit of GRSw (beta = 0.02 +/- 0.006, p = 0.00002) and by SSB intake (beta[cat4] = 0.04 +/- 0.01, p = 0.0001), showing a significant interaction, where the strongest effect was observed in the highest GRSw-tertile and in the highest SSB consumption category (beta = 0.05 +/- 0.02, p = 0.02). SNP-wise, SSB interacted with additive effects of rs7903146 (TCF7L2) (beta = 0.05 +/- 0.01, p = 0.002) and with the G/G genotype of rs10830963 (MTNRB1B) (beta = 0.19 +/- 0.05, p = 0.001). Conclusions: The association between SSB intake and fasting glucose in the Chilean population without diabetes is modified by T2D genetic susceptibility.
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    The association between walking pace and grip strength and all-cause mortality: A prospective analysis from the MAUCO cohort
    (2023) Petermann-Rocha, Fanny; -Soto, Solange Parra; Cid, Vicente; Venegas, Pia; Huidobro, Andrea; Ferreccio, Catterina; Celis-Morales, Carlos
    Objective: This study investigated the individual and combined association of walking pace and grip strength with all-cause mortality in Chilean adults.
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    The Chile Biliary Longitudinal Study: A Gallstone Cohort
    (2021) Koshiol, Jill; Van de Wyngard, Vanessa; McGee, Emma E.; Cook, Paz; Pfeiffer, Ruth M.; Mardones, Noldy; Medina, Karie; Olivo, Vanessa; Pettit, Karen; Jackson, Sarah S.; Paredes, Fabio; Sanchez, Raul; Huidobro, Andrea; Villaseca, Miguel; Bellolio, Enrique; Losada, Hector; Carlos Roa, Juan; Hildesheim, Allan; Carlos Araya, Juan; Ferreccio, Catterina
    Gallbladder cancer (GBC) is a highly fatal cancer that can be cured through cholecystectomy if identified early. The presence of gallstones is the primary risk factor for GBC, but few people with gallstones develop GBC. A key question is what drives the development of GBC among persons with gallstones. We initiated the Chile Biliary Longitudinal Study (Chile BiLS) to address this question. From 2016 to 2019, Chile BiLS enrolled 4,726 women aged 50-74 years with ultrasound-detected gallstones from southern-central Chile, accounting for an estimated 36% of eligible women with gallstones in the study area. The median age was 59 years; 25% of the women were Amerindian (Mapuche), 60% were obese, 25% had diabetes, and 6% had cardiovascular disease. Participants will be followed for gallbladder dysplasia or cancer for 6 years. As of April 30, 2020, over 91% of those eligible completed the year 2 follow-up visit. Data being collected include epidemiologic and sociodemographic information, anthropometric measurements, blood pressure, and tooth counts. Biosamples being taken include baseline plasma, buffy coat, red blood cells, serum, blood clot from serum, and PAXgene whole blood (PreAnalytiX GmbH, Hombrechtikon, Switzerland). Complete gallbladder sampling is conducted for most participants undergoing cholecystectomy. The Chile BiLS cohort study will increase our understanding of GBC etiology and could identify potential risk stratification and early detection strategies in high-risk areas.