Browsing by Author "Kahan, BD"

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    Prevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides
    (ELSEVIER SCIENCE INC, 2003) Ortiz, AM; Troncoso, P; Kahan, BD
    Background. Renal damage secondary to ischemia-reperfusion injuries (I-R) is frequent in organ transplantation and adversely affects the graft survival. An important component of this damage is caused by initial adhesion of neutrophils and lymphocytes to endothelial cells. FTY 720, which induces lymphopenia, has previously been shown to display protective effects in models of I-R. The purpose of the present study was to evaluate the combination of FTY 720 and intracellular adhesion molecule and ICAM-1 antisense oligonucleotides (AS-oligos), an agent designed to block the adhesion process.