Browsing by Author "Labbe, Pilar"

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    Mycobacterium abscessus pulmonary infection during hepatitis C treatment with telaprevir, peginterferon and ribavirin
    (2015) Soza, Alejandro; Labbe, Pilar; Arrese, Marco; Riquelme, Arnoldo; Barrera, Francisco; Benitez, Carlos; Huete, Alvaro; Elvira Balcells, M.; Labarca, Jaime
    The first generation protease inhibitors has been the mainstay of hepatitis C treatment for the last couple of years, showing marked improvement in sustained virological response, but also increased side effects. Infection has emerged as a common complication of telaprevir and boceprevir in combination with peginterferon and ribavirin, usually caused by common pathogens. We present the case of a 65 years old man who developed a Mycobacterium abscessus pulmonary infection during treatment with telaprevir, peginterferon and ribavirin. The patient was successfully treated with amikacin, imipenem and chlarithro-mycin. The present case is relevant for increasing awareness for recognition of opportunistic-infections and particularly nontuberculous mycobacterial infections in patients receiving triple therapy for chronic hepatitis C, especially in cirrhotic subjects who develop significant lymphopenia.
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    Prevalence of Advanced Liver Fibrosis and Nonalcoholic Steato-hepatitis Diagnosed by Noninvasive Methods in Chilean Type 2 Diabetic Patients
    (2014) Gallego, Consuelo; Valderas, Juan P.; Uribe, Sergio; Tejos, Cristian; Serrano, Cristobal; Huete, Alvaro; Barrera, Francisco; Liberona, Jessica; Labbe, Pilar; Quiroga, Teresa; Irarrazabal, Pablo; Arrese, Marco
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    Quantification of visceral adipose tissue using magnetic resonance imaging compared with anthropometry, in type 2 diabetic patients
    (SOC MEDICA SANTIAGO, 2012) Serrano Garcia, Cristobal; Barrera, Francisco; Labbe, Pilar; Liberona, Jessica; Arrese, Marco; Irarrazaval, Pablo; Tejos, Cristian; Uribe, Sergio
    Background: Visceral fat accumulation is associated with the development of metabolic diseases. Anthropometry is one of the methods used to quantify it. aim: to evaluate the relationship between visceral adipose tissue volume (VAT), measured with magnetic resonance imaging (MRI), and anthropometric indexes, such as body mass index (BMI) and waist circumference (WC), in type 2 diabetic patients (DM2). Patients and Methods: Twenty four type 2 diabetic patients aged 55 to 78 years (15 females) and weighting 61.5 to 97 kg, were included. The patients underwent MRI examination on a Philips Intera (R) 1.5T MR scanner. The MRI protocol included a spectral excitation sequence centered at the fat peak. The field of view included from L4-L5 to the diaphragmatic border. VAT was measured using the software Image J (R). Weight, height, BMI, WC and body fat percentage (BF%), derived from the measurement of four skinfolds with the equation of Durnin and Womersley, were also measured. The association between MRI VAT measurement and anthropometry was evaluated using the Pearson's correlation coefficient. Results: Mean VAT was 2478 +/- 758 ml, mean BMI 29.5 +/- 4.7 kg/m(2), and mean WC was 100 +/- 9.7 cm. There was a poor correlation between VAT, BMI (r = 0.18) and WC (r = 0.56). Conclusions: BMI and WC are inaccurate predictors of VAT volume in type 2 diabetic patients. (Rev Med Chile 2012; 140: 1535-1543).