Browsing by Author "Larrain, F"

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    Nature and extent of gastric lesions in symptomatic Chilean children with Helicobacter pylori-associated gastritis
    (WILEY, 2002) Guiraldes, E; Pena, A; Duarte, I; Trivino, X; Schultz, M; Larrain, F; Espinosa, MN; Harris, P
    Chile has one of the highest rates of gastric cancer in the world and most children and adolescents in the country are colonized by Helicobacter pylori. This study assessed the nature and extent of the gastric lesions in 73 consecutive patients aged 5-17 y, referred for upper gastrointestinal endoscopy. Their H. pylori-associated gastric pathology was characterized and these data were compared with their sociodemographic status. Endoscopic assessment was normal in 43 patients while in 30 there was a variety of mucosal lesions. Sixty patients (83%) had histological chronic gastritis of the antrum and in 45 (63%) the lesions also involved the gastric corpus; 90% of patients with chronic gastritis were colonized by H. pylori. Although most of these patients had epithelial erosions and dedifferentiation of the pit epithelium, atrophy and metaplasia were not found. Patients' socioeconomic status was inversely correlated with their rate of colonization by H. pylori (p < 0.005), the frequency of gastric lesions on endoscopy (p < 0.01) and the frequency of involvement of antral and corpus mucosa by chronic gastritis (p < 0.002). This latter feature was positively correlated with age (p < 0.001).
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    Proinflammatory cytokine expression in gastric tissue from children with Helicobacter pylori-associated gastritis
    (LIPPINCOTT WILLIAMS & WILKINS, 2001) Guiraldes, E; Duarte, I; Pena, A; Godoy, A; Espinosa, MN; Bravo, R; Larrain, F; Schultz, M; Harris, P
    Background: Helicobacter pylori infection of the gastric mucosa in humans is usually acquired early in life. The chronic inflammation that ensues involves the increased production of inflammatory cytokines. Published data on production of these mediators by gastric mucosa of H. pylori-infected children are few.