Browsing by Author "Leiva, Eduardo D."

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    Modulation of nuclear factor-kappa B activity can influence the susceptibility to systemic lupus erythematosus
    (WILEY-BLACKWELL PUBLISHING, INC, 2009) Kalergis, Alexis M.; Iruretagoyena, Mirentxu I.; Barrientos, Magaly J.; Gonzalez, Pablo A.; Herrada, Andres A.; Leiva, Eduardo D.; Gutierrez, Miguel A.; Riedel, Claudia A.; Bueno, Susan M.; Jacobelli, Sergio H.
    P>Autoimmune diseases, such as systemic lupus erythematosus (SLE), result from deficiencies in self-antigen tolerance processes, which require regulated dendritic cell (DC) function. In this study we evaluated the phenotype of DCs during the onset of SLE in a mouse model, in which deletion of the inhibitory receptor Fc gamma RIIb leads to the production of anti-nuclear antibodies and glomerulonephritis. Splenic DCs from Fc gamma RIIb-deficient mice suffering from SLE showed increased expression of co-stimulatory molecules. Furthermore, diseased mice showed an altered function of the nuclear factor-kappa B (NF-kappa B) transcription factor, which is involved in DC maturation. Compared with healthy animals, expression of the inhibitory molecule I kappa B-alpha was significantly decreased in mice suffering from SLE. Consistently, pharmacological inhibition of NF-kappa B activity in Fc gamma RIIb-deficient mice led to reduced susceptibility to SLE and prevented symptoms, such as anti-nuclear antibodies and kidney damage. Our data suggest that the occurrence of SLE is significantly influenced by alterations of NF-kappa B function, which can be considered as a new therapeutic target for this disease.
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    Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG
    (2008) Bueno Ramírez, Susan; González Muñoz, Pablo Alberto; Cautivo Reyes, Kelly Margarita; Mora, Jorge E.; Leiva, Eduardo D.; Tobar, Hugo E.; Fennelly, Glenn J.; Eugenin, Eliseo A.; Jacobs, William R. Jr; Riedel, Claudia A.; Kalergis Parra, Alexis Mikes
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    Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells
    (2008) González Muñoz, Pablo Alberto; Prado Terrazas, Carolina E.; Leiva, Eduardo D.; Carreño, Leandro J.; Bueno Ramírez, Susan; Riedel, Claudia A.; Kalergis Parra, Alexis Mikes
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    Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells
    (2010) Bueno Ramírez, Susan; Wozniak Banchero, Aniela; Leiva, Eduardo D.; Riquelme Colet, Sebastián Alejandro; Carreño Márquez, Leandro Javier; Hardt, Wolf Dietrich; Riedel, Claudia A.; Kalergis Parra, Alexis Mikes