Browsing by Author "Liberman Salazar, Paulina"

Now showing 1 - 9 of 9
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    Analyzing the demographics of patients with uveitis in an indigent, urban population
    (2023) Tipton, Caroline W.; Reilly, Grace R.; Chen, Kevin; Chang, Eileen; Ackert, Jessica M.; Liberman Salazar, Paulina; Berkenstock, Meghan K.
    Abstract Purpose To study the types of uveitis examined in a hospital serving indigent populations in need of low-cost care. Methods A retrospective chart review examined the electronic medical records of all patients with uveitis-related at Drexel Eye Physicians. Data collected included demographics, anatomic location of the uveitis, systemic disease associations, treatment modalities and insurance. Statistical analysis was performed using χ² or Fischer exact tests. Results 270 patients (366 eyes) were included for analysis, 67% of patients identified as African American. Most eyes (95.3%, N = 349) were treated with topical corticosteroid drops, and only 6 (1.6%) received an intravitreal implant. Immunosuppressive medications were started in 24 patients (8.9%). Nearly 80% depended to some extent on Medicare or Medicaid Assistance for treatment coverage. There was no association between insurance type and use of biologics or difluprednate. Conclusion We found no association between insurance type and the prescription of medications for uveitis that should be used at home. There was a minimal number of patients prescribed medications for implantation in the office. The adherence of use of medications at home should be investigated.
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    Changes in patient visits and diagnoses in a large academic center during the COVID-19 pandemic
    (2021) Berkenstock, Meghan K.; Liberman Salazar, Paulina; McDonnell, Peter J.; Chaon, Benjamin C.
    Abstract Background To minimize the risk of viral transmission, ophthalmology practices limited face-to-face encounters to only patients with urgent and emergent ophthalmic conditions in the weeks after the start of the COVID-19 epidemic in the United States. The impact of this is unknown. Methods We did a retrospective analysis of the change in the frequency of ICD-10 code use and patient volumes in the 6 weeks before and after the changes in clinical practice associated with COVID-19. Results The total number of encounters decreased four-fold after the implementation of clinic changes associated with COVID-19. The low vision, pediatric ophthalmology, general ophthalmology, and cornea divisions had the largest total decrease of in-person visits. Conversely, the number of telemedicine visits increased sixty-fold. The number of diagnostic codes associated with ocular malignancies, most ocular inflammatory disorders, and retinal conditions requiring intravitreal injections increased. ICD-10 codes associated with ocular screening exams for systemic disorders decreased during the weeks post COVID-19. Conclusion Ophthalmology practices need to be prepared to experience changes in practice patterns, implementation of telemedicine, and decreased patient volumes during a pandemic. Knowing the changes specific to each subspecialty clinic is vital to redistribute available resources correctly.
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    Clinical Features and Prognostic Factors in Presumed Ocular Tuberculosis
    (2017) Castiglione E.; Calonge, M.; Urzua, C.; Lantigua, Y.; Abuauad, S.; Liberman Salazar, Paulina; Berger, O.; Sabat, P.; Velásquez, V.
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    Dupilumab associated conjunctivitis in patients with atopic dermatitis
    (2020) Liberman Salazar, Paulina; Shifera, A. S.; Berkenstock, M.
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    Efectividad del moxifloxacino intracameral para reducir la Endoftalmitis posterior a cirugía de cataratas en población chilena
    (2023) Garretón Cárcamo, Rodolfo Ignacio; Liberman Salazar, Paulina; Sanhueza Pasten, Camila Alejandra; Cruzat Corssen, Andrea; Coria, Marcelo
    Estudio de cohorte no concurrente cuyo propósito fue evaluar la efectividad del moxifloxacino intracameral profiláctico para reducir la frecuencia de endoftalmitis posterior a cirugía de cataratas en el Hospital Dr. Sótero del Río. Se revisaron todos los registros quirúrgicos entre el 2012 y el 2020, evaluando si se utilizó moxifloxacino intracameral. Posteriormente se registraron todos los pacientes que recibieron tratamiento por endoftalmitis, y se evaluaron sus características, si hubo uso de moxifloxacino y si la cirugía tuvo alguna complicación. Se encontraron 22.869 cirugías de cataratas, con un promedio de 2.541 operaciones anuales. El moxifloxacino intracameral se comenzó a usar el 2014 progresivamente, ocupándose en un 80% de las cirugías en el 2018. 15 ojos evolucionaron con endoftalmitis. Hubo una tendencia a favor del uso de moxifloxacino intracameral, sin embargo, esto no fue estadísticamente significativo. En el grupo de endoftalmitis, 33,3% tenían diabetes mellitus, en 13,3% hubo rotura de capsula posterior y 60% eran de pacientes mujeres. No hay registro de endoftalmitis entre el 2018 y el 2020 luego de cirugía de cataratas. En conclusión, a pesar de haber una tendencia a favor del uso de moxifloxacino intracameral, se requiere un periodo mayor de observación para confirmar esta hipótesis.
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    Effectiveness of difluprednate in addition to systemic therapy for the treatment of anterior scleritis
    (BMJ Publishing Group, 2023) Liberman Salazar, Paulina; Thorne, Jennifer; Burkholder, Bryn; Berkenstock, Meghan K.
    Aim: To describe the effectiveness and side-effect profile of adding difluprednate therapy to patients with anterior scleritis being treated systemically.MethodsRetrospective chart review. Charts from all patients with anterior scleritis who were treated with topical difluprednate in addition to systemic therapy from 1 January 2018 to 1 January 2020 were reviewed. Data collected included: demographics, scleritis type, systemic diagnosis, presence of nodules or necrosis, changes in scleritis activity, intraocular pressure (IOP), number of difluprednate drops used, type of systemic treatment used, best-corrected visual acuity (BCVA) and lens status. The primary outcome was clinical resolution of scleritis. Secondary outcomes included BCVA loss & GE;2 lines, change in lens status or cataract surgery and IOP & GE;24 mm Hg.ResultsThirty-two patients (44 eyes) were analysed. The median age was 57 years (IQR 52, 72); 59% were female; 72% were Caucasian. An associated systemic disease was present in 59%. Systemic therapies used when difluprednate was added were: 65% immunosuppressive agents, 43% prednisone and 25% non-steroidal anti-inflammatory drugs. The addition of difluprednate resulted in clinical resolution in 79.6% of the treated eyes. Median time to inactivity was 9 weeks (IQR 5, 20). Eyes initially using 2-4 drops per day had a higher response rate (89%, p=0.005). Over a median follow-up of 34 weeks (IQR 21, 74), 11 eyes had IOP elevation; 6 eyes lost & GE;2 lines of BCVA, 5 eyes had cataract progression.ConclusionMost eyes treated with difluprednate achieved inactivity. The addition of difluprednate to systemic therapies provides an alternative to achieve control of inflammation.
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    Escalation to weekly adalimumab for the treatment of ocular Inflammation
    (2020) Liberman Salazar, Paulina; Berkenstock, M. K.; Burkholder, B. M.; Chaon, B. C.; Thorne, J. E.
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    Evaluation of the Accuracy of T-SPOT.TB for the Diagnosis of Ocular Tuberculosis in a BCG-vaccinated, Non-endemic Population
    (2016) Urzua, Cristhian A.; Liberman Salazar, Paulina; Abuauad, Sergio; Sabat, Pablo; Castiglione, Enzo; Beltran Videla, María A.; Aguilera Insunza, Raquel
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    Primer Consenso Chileno de Grupo de Estudio de Tuberculosis Ocular
    (Sociedad Chilena de Infectologia, 2023) Urzua, C.A.; Liberman Salazar, Paulina; Escobar, N.; Sabat, P.; Hernández, M.; Peña García, Luis Enrique; Stevenson, R.; Pérez, M.E.; Balcells Marty, María Elvira
    The treatment of ocular tuberculosis (TB) remains controver-sial worldwide. The development of guidelines for ocular TB can facilitate the approach and management of these patients. These guidelines should be developed regionally, considering the local TB epidemiology. The objectives of this consensus are: to initiate an in-terdisciplinary discussion about the epidemiology, pathophysiology, clinical presentation, diagnosis, workup and treatment of patients with ocular TB, to establish a treatment algorithm and define which patients should be treated in Chile and how and, to analyze and discuss the published data regarding chemoprophylaxis for patients with latent TB who need to start immunosuppressive treatment due to inflammatory ocular conditions.