Browsing by Author "Maggio, L"

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    Pharmacokinetics of ketorolac in children after abdominal surgery
    (DUSTRI-VERLAG DR KARL FEISTLE, 1997) GonzalezMartin, G; Maggio, L; GonzalezSotomayor, J; Zuniga, S
    The pharmacokinetics of 2 doses of intravenous ketorolac (0.5 and 0.9 mg x kg(-1)) were studied in 14 children (age 2 - 8 years). A single dose of the drug was injected into the dorsum vein of one hand. Blood samples were collected at regular time intervals for 6 hours. Serum ketorolac concentrations were assayed using a high pressure liquid chromatography method. Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume (Vd(area)), the total clearance (Cl-total), and elimination half-life (t(1/2 beta)) were similar in both groups of children who either received 0.5 or 0.9 mg x kg(-1) of ketorolac. The estimated geometric mean Vd(area), Cl-total, and t(1/2 beta) ratios (95% CI in parentheses) for 0.9 mg x kg(-1): 0.5 mg x kg(-1) were 1.24 (0.82, 1.50), 1.14 (0.88, 1.23), and 1.083 (0.40, 1.81), respectively. The pharmacokinetic parameters found in this study are different from those found by other authors in adult subjects.