Browsing by Author "Majerson Grinberg, Alejandro"

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    Bipolar or monopolar transurethral resection for benign prostatic hyperplasia?
    (2018) Inzunza, Gabriel; Rada G., Gabriel; Majerson Grinberg, Alejandro
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    Bladder squamous cell carcinoma in a pregnant woman: case report and review of the literature
    (2021) Rojas, Pablo A.; González, Cristián; Méndez Olivieri, Gonzalo Patricio; Majerson Grinberg, Alejandro; San Francisco Reyes, Ignacio Felipe
    Abstract Background Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described. Case presentation We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. After a C-section at 30 weeks, we performed radical cystectomy with extended bilateral lymphadenectomy, hysterectomy and right oophorectomy. The Studer neobladder technique was performed for urinary tract reconstruction. Definitive pathology showed invasive bladder squamous cell carcinoma, Grade 2, with microscopic infiltration of the perivesical fat, negative margins, and 3/28 lymph nodes with carcinoma (pT3aN2M0). The patient underwent 18 months of surveillance after radical cystectomy, without recurrence by PET-CT. Conclusions Bladder cancer in pregnant women is extremely rare but must be considered in those with recurrent gross hematuria and/or recurrent urinary tract infection. To our knowledge, this case involves the longest recurrence-free survival of a pregnant woman with squamous cell bladder cancer published thus far.
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    Early ureteroscopic treatment in patients with urosepsis associated with ureteral calculi is a safe approach. A pilot study
    (2019) Astroza Eulufi, Gastón Maximiliano; Sarras, M.; Salvado, José A.; Majerson Grinberg, Alejandro; Neira, R.; Domínguez C., Javier
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    Hypothermic machine perfusion versus static cold preservation in kidney transplantation
    (2018) Dominguez, J.I.; De Amesti, M.; Majerson Grinberg, Alejandro
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    Labhardt's colpoperineocleisis : subjective results of an alternative treatment for genital prolapse in patients who are not sexually active-2-year follow-up
    (2014) Pizarro Berdichevsky, Javier Alejandro; Galleguillos Leyton, Gonzalo Ignacio; Cuevas Gallegos, Rodrigo; Blümel, Bernardita; Pattillo Garnham, Alejandro; González, Silvana; Majerson Grinberg, Alejandro; Padilla Pérez, Oslando; Cuello F., Mauricio; Ortiz Castro, Juan Andrés; Goldman, Howard B.
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    Mismatch repair expression in testicular cancer predicts recurrence and survival
    (2008) Velasco Palma, Alfredo Alejandro; Corvalán Rodríguez, Alejandro; Wistuba, Ignacio I.; Riquelme, Erick; Chuaqui, Rodrigo; Majerson Grinberg, Alejandro; Leach, Fredrick S.
    We investigated mismatch repair (MMR) gene expression in testicular cancer as a molecular marker for clinical outcome (recurrence, response to chemotherapy and death) using protein expression and specific genetic alterations associated with the presence or absence of MMR activity. One hundred sixty-two cases of paraffin-embedded testis cancer specimens were subjected to immunohistochemical analysis using monoclonal antibody for MLH1 and MSH2 MMR proteins and genetic analysis using specific polymorphic markers. The degree of MMR immunoreactivity and genetic instability in the form of loss of heterozygosity (LOH) and/or microsatellite instability (MSI) were determined by comparing matched normal and tumor tissue. The degree of immunohistochemical staining for MMR expression was associated with a shorter time to tumor recurrence, resistance to chemotherapy and death. Furthermore, clinical relapse and cancer specific death was also associated with tumors exhibiting a high degree of MSI, p = 0.01 and 0.04, respectively. In contrast, LOH was not associated with recurrence, resistance to chemotherapy or death. Therefore, MMR expression defines testis cancers with distinct molecular properties and clinical behavior, such that tumors with decreased MMR immunostaining and/or increased frequency of MSI have a shorter time to recurrence and death despite chemotherapy. (c) 2007 Wiley-Liss, Inc.