Browsing by Author "Martínez García, Alejandra Constanza"

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    Detection of a novel severe mutation affecting the CYP21A2 gene in a Chilean male with salt wasting congenital adrenal hyperplasia
    (2020) Arteaga U., Eugenio; Valenzuela Pino, Felipe Patricio; Lagos, C. F.; Lagos, M.; Martínez García, Alejandra Constanza; Baudrand Biggs, René; Carvajal Maldonado, Cristián Andrés; Fardella B., Carlos
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    Early pregnancy thyroid hormone reference ranges in Chilean women: the influence of body mass index
    (2016) Mosso Gómez, Lorena; Martínez García, Alejandra Constanza; Rojas Villar, María Paulina; Latorre Selvat, Gonzalo Ignacio; Margozzini Maira, Paula; Lyng, Trinidad; Carvajal C., Jorge A.; Campusano Montano, Claudia V.; Arteaga U., Eugenio; Boucai, Laura
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    Estrone Is a Strong Predictor of Circulating Estradiol in Women Age 70 Years and Older
    (2020) Davis, S. R.; Martínez García, Alejandra Constanza; Robinson, P. J.; Handelsman, D. J.; Desai, R.; Wolfe, R.; Bell, R. J.
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    The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor
    (2024) Vecchiola Cárdenas, Andrea Paola; Uslar N., Thomas; Friedrich, Isidora; Aguirre, Joaquín; Sandoval, Alejandra; Carvajal, Cristian A.; Tapia Castillo, Alejandra; Martínez García, Alejandra Constanza; Fardella B., Carlos
    Blood pressure (BP) regulation is a complex process involving various hormones, including aldosterone and its mineralocorticoid receptor. Mineralocorticoid receptor is expressed in several tissues, including the kidney, and plays a crucial role in regulating BP by controlling the sodium and water balance. During different stages of life, hormonal changes can affect mineralocorticoid receptor activity and aldosterone levels, leading to changes in BP. Increasing evidence suggests that sex steroids modulate aldosterone levels. Estrogens, particularly estradiol, mediate aldosterone biosynthesis by activating classical estrogen receptors and the G protein-coupled receptor. Progesterone acts as an anti-mineralocorticoid by inhibiting the binding of aldosterone to the mineralocorticoid receptor. Moreover, progesterone inhibits aldosterone synthase enzymes. The effect of testosterone on aldosterone synthesis is still a subject of debate. However, certain studies show that testosterone downregulates the mRNA levels of aldosterone synthase, leading to decreased plasma aldosterone levels.