Browsing by Author "McNab, Paul"
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- ItemCardiac dyssynchrony correlates with left ventricular remodeling after myocardial infarction(SOC MEDICA SANTIAGO, 2009) McNab, Paul; Castro, Pablo; Gabrielli, Luigi; Verdejo, Hugo; Carlos Quintana, Juan; Rodriguez, Jose A.; Corbalan, RamonBackground: Cardiac dyssynchrony is common in advanced heart failure (HF), but the changes in cardiac synchrony after myocardial infarction (MI) have not been adequately described. Aim: To study the relationship between cardiac synchrony and left ventricular remodeling after acute myocardial infarction. Material and methods: Forty nine patients aged 59+/-10 years (77% men) with a first episode of a ST segment elevation MI were studied. Scintigraphic left ventricular function and synchrony analyses were performed at baseline and after a six months follow-up. Determinations were compared with 33 healthy subjects. Results: At baseline, patients with MI had a decreased left ventricular ejection fraction (LVEF) and significant dyssynchrony, when compared with controls. LVEF was 36.4%+/-10%, left ventricular end-diastolic volume (LVEDV) 127+/-38 mL, interventricular delay (IEV) 29+/-35 milliseconds (ms), and intraventricular delay (IAV), 234+/-89 ms. After 6 months, LVEF significantly improved (38%+/-10%, p = 0.042) without significant changes in LVEDV (129+/-32 mL, p = 0.97), IEV (24+/-17, p = 0.96) or IAV (231 +/- 97, p = 0.34). At baseline there were significant correlations between IAV and LVEF, and between IAV and LVEDV (r = -0.48, p = 0.001 and r = -0.41, p = 0.004, respectively). These correlations remained significant after 6 months. There was a positive correlation between IAV and LVEDV changes at six months (r = 0.403, p = 0.04). Conclusions: The development of cardiac dyssynchrony correlates with adverse left ventricular remodeling after MI (Rev Med Chile 2009; 137: 1457-62).
- ItemMarkedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure(MOSBY-ELSEVIER, 2011) Paz Ocaranza, Maria; Gabrielli, Luigi; Mora, Italo; Garcia, Lorena; McNab, Paul; Godoy, Ivan; Braun, Sandra; Cordova, Samuel; Castro, Pablo; Novoa, Ulises; Chiong, Mario; Lavandero, Sergio; Jalil, Jorge E.Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with heart failure (HF). We hypothesized that, in patients with chronic HF, Rho-kinase in circulating leukocytes is activated and related to left ventricular (LV) remodeling and dysfunction.