Browsing by Author "Mendez, C"

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    Chronic nonbacterial osteomyelitis in children: a multicenter case series
    (2020) Concha, S; Hernández-Ojeda, A; Contreras Olea, Oscar; Mendez, C; Talesnik Guendelman, Eduardo; Borzutzky Schachter, Arturo
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    The Chilean version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)
    (2001) Miranda, M; Ruperto, N; Toso, MS; Lira, LW; Gonzalez, B; Norambuena, X; Quezada, A; De Inocencio, J; Mendez, C
    We report herein the results of the cross-cultural adaptation and validation into the Chilean language of the parent's version of two health related quality of life instruments. The Childhood Health Assessment Questionnaire (CHAQ) is a disease specific health instrument that measures functional ability in daily living activities in children with juvenile idiopathic arthritis (RA). The Child Health Questionnaire (CHQ) is a generic health instrument designed to, capture the physical and psychosocial wellbeing of children independently from the underlying disease. The Chilean CHAQ-CHQ were derived from the European Spanish version with changing of the few words whose use is different in the 2 countries. A total of 126 subjects were enrolled: 72 patients with RA (29% systemic onset, 39% polyarticular onset, 4% extended oligoarticular subtype, and 28% persistent oligoarticular subtype) and 54 healthy children. The CHAQ clinically discriminated between healthy subjects and RA patients, with the RA patients having a higher degree of disability pain, and a lower overall well-being when compared to their healthy, peers. Also the CHQ clinically, discriminated between healthy, subjects and RA patients, with the RA patients having a lower physical and psychosocial well-being when compared to their healthy, peers.
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    Time course of antibody response to tetanus toxoid and pneumococcal capsular polysaccharides in patients infected with HIV
    (LIPPINCOTT WILLIAMS & WILKINS, 1998) Talesnik, E; Vial, PA; Labarca, J; Mendez, C; Soza, X
    The temporal course of the humoral immune response to T-cell-dependent and T-cell-independent type 2 antigens was evaluated in HIV-infected patients. In all, 26 seropositive patients were vaccinated with tetanus toroid and 23-valent pneumococcal vaccines; total IgG and IgG1 antibodies to tetanus toroid (Ttox) and total IgG and IgG2 antibodies against 23 Streptococcus pneumoniae capsular antigens (PPS) were measured at baseline, 2 months, and 12 months after vaccination. For the Ttox, baseline levels of IgG1 (Ttox-IgG1) increased from 11.0 to 19.5 mg/L at 2 months postimmunization. Overall only 6 patients (23%) showed a significant response. At 12 months postvaccination, Ttox-IgG and T-tox-IgG1 were significantly lower than baseline levels (Ttox IgG basal; 11.0 mg/L, 12 months; 0.8 mg/L, Ttox IgG1 baseline; 13.1 mg/L, Ttox IgG1 12 months; 2.4 mg/L) and in 10 patients, antibodies that fell below protective levels (0.6 mg/L). In contrast with PPS, a significant response was observed at 2 and 12 months (PPS-IgG basal; 35.9 U/ml, 2 months; 151.4 U/ml, 12 months; 59.7 U/ml; PPS-IgG2 baseline 20.3 U/ml, 2 months; 113.2 U/ml, 12 months; 51..9 U/ml). Overall, 19 patients (76%) showed an immune response to pneumococcal polysaccharides antigens. Immunization with the Ttox T-cell-dependent antigen fails to elicit a significant immune response and may induce inhibition of antibody production in HIV-infected patients. In contrast, immunization with a T-cell-independent type 2 antigen can cause the pneumococcal polysaccharides to induce significant immune response in a high proportion of HIV-infected patients.