Browsing by Author "Moreno, Manuel"

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    Adiponectin levels, cardiometabolic risk factors and markers of subclinical atherosclerosis in children
    (ELSEVIER IRELAND LTD, 2010) Arnaiz, Pilar; Acevedo, Monica; Barja, Salesa; Aglony, Marlene; Guzman, Beatriz; Cassis, Berta; Carvajal, Jacqueline; Moreno, Manuel; Navarrete, Carlos; Berrios, Ximena
    Background: Low levels of adiponectin have been associated with metabolic risk factors (RF) and cardiac disease. Minimal data is available about the relationship between adiponectin and subclinical atherosclerosis. Objectives: To determine the relationship of adiponectin to cardiometabolic RF, C-reactive protein (CRP), anthropometric parameters of obesity, and subclinical atherosclerosis in children.
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    Evaluation of new natural compound formulations on the modification of metabolic syndrome components among overweight adults
    (2022) Ebensperger, Roberto; Moreno, Manuel; Plaza, Cristian; Bridi, Raquel
    Overweight and obesity, increasingly frequent conditions in Chile and the world, are defined as chronic diseases characterized by the excessive accumulation of body fat, that can be detrimental to health. Excess body fat is the main pathogenic factor for the development of insulin resistance and metabolic syndrome, the latter characterized by a cluster of metabolic abnor-malities that increase risk of metabolic diseases and cardiovascular mortality. The objective of this preliminary cross-sectional, observational study was to evaluate a new formulation of natural compounds, Delphinol (R), resveratrol and oleanolic acid, against metabolic syndrome components in a young population with excess weight, through the intake during 22 weeks of the new formulation. The evaluation was carried out based on the clinical and anthropometric status of 20 volunteer subjects (both gender, 18 to 30 years and BMI26 to 42), medical evaluation and laboratory tests using each metabolic syndrome component (abdominal obesity, triglycerides, HDL, blood pressure y fasting glicaemia). It was observed that with the daily intake of this formulation there was a significant reduction in blood glucose levels, HOMA-IR index, triglycerides and an increase in HDL-cholesterol. These preliminary results would translate into a benefit in the health status of overweight and obese individuals, which would impact on reducing rates of metabolic syndrome. Thus, slowing down the progression of chronic diseases such as diabetes and dyslipidemia, and also contributing to decreasing the associated cardiometabolic risk.
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    Influence of obesity on health care costs and absenteeism among employees of a mining company
    (SOC MEDICA SANTIAGO, 2009) Zarate, Aldo; Crestto, Marco; Maiz, Alberto; Ravest, Gonzalo; Ines Pino, Maria; Valdivia, Gonzalo; Moreno, Manuel; Villarroel, Luis
    Background: The health associated costs of obesity can represent obesity on health care costs and absenteeism in a cohort of mine workers. Patients and methods: Prospective study of 4.673 of men, employees of a mining company, aged 49 +/- 7 years that were followed for 24 +/- 11 months. Total health care costs and days of sick leave were recorded for each individual. The association between obesity and these variables and analyzed by logistic regression adjusting for co-morbidities, age and other variables. Results: Mean annual health care cots for obese workers were 17% higher (p<0.001) compared to workers with normal weight and 58% higher (p<0.001) for workers with severe and morbid obesity. Mean annual days of sick leave increased by 25% in the obese (p=0.002) and by 57% in subjects with severe and morbid obesity (p<0.001). For health care costs the most significant predictors were: presence of diabetes mellitus (Odds ratio (OR) 6.21, 95% confidence intervals (95% CI) 4.9 to 7.9), hypertension (OR 3.99; 95% CI 3.4 to 4.6) and severe and morbid obesity (OR 2.55, 95% CI 1.9 to 3.4). For absenteeism the most significant predictors were; presence of diabetes mellitus (OR 1.58, 95% CI 1.2 to 2.0), hypertension (OR 1.34, 95% CI 1.2 to 1.6) and severe and morbid obesity (OR 1.50, 95% CI 1.1 to 2.1). Conclusions: Obesity increases significantly health care costs and absenteeism (Rev Med Chile 2009; 137: 337-44).