Browsing by Author "Munoz, Gonzalo"

Now showing 1 - 5 of 5
  • No Thumbnail Available
    Item
    Chile: School leadership challenged by double accountability towards schools
    (ROUTLEDGE, 2016) Weinstein, Jose; Marfan, Javiera; Horn, Andrea; Munoz, Gonzalo; Easley II, Jacob; Tulowitzki, Pierre
    The presence of accountability conceptualization in educational research is related to a pro-accountability trend in school systems, which has been described, among others, by Organization for Economic Co-operation and Development (OECD) and specifically for the United States by Darling-Hammond. Under the dictatorship of General Pinochet, Chile experienced a sort of capitalist revolution, becoming a country where the neoliberal ideas of Milton Friedman were put into full swing, elevating the market as playing a significant role in national development. The main achievement attained by this market system was the growth in numbers of students inside the school system. The Preferential School Subvention Law (SEP) revolutionized the top-down support forms, based on centralized programs, which in the 1990s the Ministry of Education set in motion in order to boost the educational quality of most vulnerable facilities. The main results that principals are supposed to achieve are in line with the two forms of accountability that have become prevalent in Chilean school system.
  • Thumbnail Image
    Item
    Dialogues and self-reference: change processes in psychotherapy from speech acts's perspective
    (FOUNDATION ADVANCEMENT PSYCHOLOGY, 2009) Aristegui, Roberto; Gaete, Joaquin; Munoz, Gonzalo; Salazar, Jose I.; Krause, Mariane; Vilches, Oriana; Tomicic, Alemka; Ramirez, Ivonne
    This article is the result of a research in the frame of therapeutic process, based on Generic Change Indicators (Krause et al., 2006a). Along with Speech Acts Theory (Searle, 2002; Aristegui et al., 2005) it is proposed to use the Dialogical Self Model (Hermans, 1996; Valsiner, 2007) as a suitable device for characterizing and differentiating change and stagnant episodes, in therapeutic conversation. The analysis unit of study is constituted by extracts from two therapies of different theoretical orientation, with change and stagnant episodes previously identified through indicators derived from Subjective Change Theory. The study of change episodes indicates dialogical characteristics of the therapeutic conversation which suppose a self-referential language game where therapist and consultant build a self-position description (subject) that commits with certain ilocutive intentions of action. The study and comparison of change episodes with stagnate episodes integrate in the discussion the distinctions of experience focus in first person and veritative symmetry applied to self referential-performativity and the notions self-dialogicality dialogicality according to the self-dialoglical theory (Hermans, 1996; Valsiner, 2007; Anderson, 1999).
  • Thumbnail Image
    Item
    Effects of uneven mass distribution on plasma dynamics in cylindrical wire array Z-pinches
    (2015) Veloso Espinosa, Felipe Eduardo; Donoso, Luis; Swadling, George; Chittenden, Jeremy; Munoz, Gonzalo; Valenzuela, Vicente; Suzuki-Vidal, Francisco; Favre Domínguez, Mario; Wyndham, Edmund
  • Thumbnail Image
    Item
    Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium
    (WILEY, 2006) Munoz, Gonzalo; San Martin, Rody; Farias, Marcelo; Cea, Luis; Vecchiola, Andrea; Casanello, Paola; Sobrevia, Luis
    L-Arginine transport and nitric oxide (NO) synthesis (L-arginine/NO pathway) are stimulated by insulin, adenosine or elevated extracellular D-glucose in human umbilical vein endothelial cells (HUVEC). Adenosine uptake via the human equilibrative nucleoside transporters 1 (hENT1) and 2 (hENT2) has been proposed as a mechanism regulating adenosine plasma concentration, and therefore its vascular effects in human umbilical veins. Thus, altered expression and/or activity of hENT1 or hENT2 could lead to abnormal physiological plasma adenosine level. We have characterized insulin effect on adenosine transport in HUVEC cultured in normal (5 mM) or high (25, mM) D-glucose. Insulin (1 nM) increased overall adenosine transport associated with higher hENT2-, but lower hENT1-mediated transport in normal D-glucose. insulin increased hENT2 protein abundance in normal or high D-glucose, but reduced hENT1 protein abundance in normal D-glucose. Insulin did not alter the reduced hENT1 protein abundance, but blocked the reduced hENT1 and hENT2 mRNA expression induced by high D-glucose. Insulin effect on hENT1 mRNA expression in normal D-glucose was blocked by N-G-nitro-L-arginine methyl ester (L-NAME, NO synthase inhibitor) and mimicked by S-nitroso-N-acetyl-L,D-penicillamine (SNAP, NO donor). L-NAME did not block insulin effect on hENT2 expression. In conclusion, insulin stimulation of overall adenosine transport results from increased hENT2 expression and activity via a NO-independent mechanism. These findings could be important in hyperglycemia-associated pathological pregnancies, such as gestational diabetes, where plasma adenosine removal by the endothelium is reduced, a condition that could alter the blood flow from the placenta to the fetus affecting fetus growth and development. J. Cell. Physiol. 209: 826-835, 2006. (c) 2006 Wiley-Liss, Inc.
  • No Thumbnail Available
    Item
    Monitoring of anticoagulant treatment with Unfractionated Heparin in pediatrics
    (2022) Aguirre, Noemi; Rivera, Carolina; Munoz, Gonzalo; Valle, Patricio; Panes, Olga; Zuniga, Pamela
    Unfractionated heparin (UFH) is the most widely used anticoagulant in hospitalized patients. The therapeutic range (TR) was defined in adults according to the prolongation of the activated Partial Thromboplastin Time (aPTT). However, the recommendation is to maintain a therapeutic range with anti-factor Xa assay (antiFXa). As this technique is more complex to perform and less available, it is recommended to make local correlation curves of aPTT with antiFXa. Objective: to determine the correlation between the values of aPTT and antiFXa in patients treated with UFH. Patients and Method: 52 patients between 2 days to 14 years of age hospitalized in the Pediatric Critical Patient Unit were recruited. They received treatment with UFH in continuous infusion for at least 24 hours. aPTT and antiFXa tests were performed according to the moment of anticoagulation. To evaluate the concordance of the levels of aPTT with those of antiFXa, the Kappa statistical coefficient of Landis and Koch was used. Results: 105 samples were collected from 52 patients. The overall concordance was 0.452 (moderate correlation). In patients aged < 1 month (n = 40), a considerable correlation was evident (r = 0.617); in those from 1 month to < 6 months (n = 18) and 6 months -< 12 months with aPTT < 120 seconds (n = 11), also showed a considerable correlation (r = 0.636 and 0.615, respec-tively), while in those aged > 12 months (n = 37) with aPTT < 120 seconds, a moderate correlation was evident (r = 0.454). Conclusion: In our population, there is a moderate correlation between the values of aPTT and antiFXa.