Browsing by Author "Navarrete Dechent, Cristian Patricio"

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    Author Correction: A systematic review and meta-analysis of artificial intelligence versus clinicians for skin cancer diagnosis
    (2024) Salinas Espinoza, María Paz; Sepúlveda, Javiera; Hidalgo, Leonel; Peirano, Dominga; Morel, Macarena; Uribe, Pablo; Rotemberg, Verónica; Briones, Juan; Mery, Domingo; Navarrete Dechent, Cristian Patricio
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    Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial
    (2024) Borzutzky Schachter, Arturo José; Iturriaga Ortiz, Carolina Alejandra; Pérez Mateluna, Guillermo Andres; Cristi, Francisca; Cifuentes Aguila, Lorena Isabel; Silva‐Valenzuela, Sergio; Vera Kellet, Cristian Andres; Cabalín Arenas, Carolina Andrea; Hoyos Bachiloglu, Rodrigo Andres; Navarrete Dechent, Cristian Patricio; Cossio Traverso, Maria Laura; Le Roy, Catalina; Camargo, Jr, Carlos A.
    Background: Vitamin D (VD) deficiency is common among patients with atopic dermatitis (AD) and often associated with severity. However, randomized trials of VD supplementation in AD have had equivocal results, and there is little information regarding the effect of VD supplementation on type 2 immunity in AD patients.Objectives: To investigate the efficacy of VD supplementation to decrease severity of AD and to alter type 2 immunity biomarkers.Methods: We performed a randomized, double-blind, placebo-controlled trial. We randomly assigned 101 children with AD to weekly oral vitamin D3 (VD3) or placebo for 6 weeks. The primary outcome was the change in the Severity Scoring of AD (SCORAD).Results: Mean age of subjects was 6.3 ± 4.0 years, and baseline SCORAD was 32 ± 29. At baseline, 57% of children were VD deficient, with no difference between groups. Change in 25(OH)D was significantly greater with VD3 than placebo (+43.4 ± 34.5 nmol/L vs. +2.3 ± 21.2 nmol/L, p < 0.001). SCORAD change at 6 weeks was not different between VD and placebo (-5.3 ± 11.6 vs. -5.5 ± 9.9, p = 0.91). There were no significant between-group differences in change of eosinophil counts, total IgE, Staphylococcal enterotoxin specific IgE, CCL17, CCL22, CCL27, LL-37 or Staphylococcus aureus lesional skin colonization. Vitamin D receptor (VDR) gene single nucleotide polymorphisms FokI, ApaI and TaqI did not modify subjects' response to VD supplementation.Conclusions: Among children with AD, weekly VD supplementation improved VD status but did not modify AD severity or type 2 immunity biomarkers compared to placebo (ClinicalTrials.gov NCT01996423).
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    Multiple familial trichoepithelioma: confirmation via dermoscopy.
    (2016) Navarrete Dechent, Cristian Patricio; Bajaj, Shirin; Marghoob, Ashfaq A; González, Sergio; Muñoz, Daniel
    Trichoepitheliomas are uncommon benign adnexal neoplasms that originate from the hair follicles. Multiple familial trichoepithelioma constitute an autosomal dominant disease characterized by the appearance of multiple flesh-colored, symmetrical papules, tumors and/or nodules in the central face and occasionally on the scalp. Although clinical diagnosis is usually straightforward in light of the family history and naked-eye examination, dermoscopy may aid in its confirmation. Dermoscopy of each papule revealed in-focus arborizing vessels, multiple milia-like cysts and rosettes amidst a whitish background. In a patient with multiple facial papules revealing a dermoscopic appearance described above, the diagnosis of sporadic or familial multiple trichoepithelioma should be considered.
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    "One blade, two cuts?" A multidisciplinary survey investigating practice variability of scalpel blade change for simultaneous excision of multiple skin lesions in the same patient
    (WILEY, 2024) Pietkiewicz, Pawel; Stefaniak, Aleksandra; Giedziun, Piotr; Calik, Jacek; Lewandowicz, Michal; Mazur, Ewelina; Cantisani, Carmen; Navarrete Dechent, Cristian Patricio; Akay, Bengue N.; Szepietowski, Jacek C.; Rosendahl, Cliff
    Background: Skin cancer incidence increases globally, requiring effective preventive measures and evidence-based treatment strategies. Current guidelines advocate for surgical excision as a first-line treatment for most early skin cancers. The study investigated practices regarding changing scalpel blades when excising multiple skin lesions in the same patient during the same visit (CSB) and explored how beliefs about iatrogenic seeding influence individual norms of practice.MethodsA multidisciplinary survey was conducted among 173 medical specialists involved in skin cancer care. Participants provided demographic information, years of experience, and practices regarding CSB in four clinical scenarios (first excised tumor: basal cell carcinoma, squamous cell carcinoma, melanoma suspect, and evident melanoma). Practice variations based on specialty, experience, and beliefs about seeding risk were statistically assessed.ResultsSurgeons exhibited a significantly higher tendency to change blades compared to non-surgeons across all diagnoses. Iatrogenic seeding (56.52%) and clinical training (18.84%) were the main reasons provided for CSB. Beliefs about seeding risk did not differ significantly between specialties.ConclusionsAlthough the practice of CSB lacks strong scientific rationale, the approach to this practice significantly varies among different medical specialties. Healthcare professionals should critically evaluate and standardize evidence-based practices to ensure optimal patient care and mitigate potential harm.
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    Pityriasis Versicolor-A Narrative Review on the Diagnosis and Management
    (MDPI, 2023) Labedz, Nina; Navarrete Dechent, Cristian Patricio; Kubisiak-Rzepczyk, Honorata; Bowszyc-Dmochowska, Monika; Pogorzelska-Antkowiak, Anna; Pietkiewicz, Pawel
    This narrative review presents a comprehensive overview of the diagnosis and management of pityriasis versicolor (PV), a common superficial fungal infection caused by the yeast Malassezia. PV is characterised by scaly hypopigmented or hyperpigmented patches, primarily affecting the upper trunk, neck, and upper arms. Regarding commensal interactions, Malassezia utilises nutrient sources without affecting the human host. In cases of pathogenicity, Malassezia can directly harm the host via virulence factors or toxins, or indirectly by triggering damaging host responses. The diagnosis typically relies on recognising characteristic clinical features. Due to the wide variability in its clinical presentation, recognising the differential diagnosis is critical. In this paper, we discuss the clinical differentials, with their dermatoscopic presentation, but also describe a range of helpful diagnostic techniques (microscopy, conventional and ultraviolet-induced fluorescence dermatoscopy, and confocal microscopy). Topical therapies are the primary treatment for PV, encompassing non-specific antifungal agents like sulphur with salicylic acid, selenium sulphide 2.5%, and zinc pyrithione. Additionally, specific topical antifungal medications with either fungicidal or fungistatic properties may also be incorporated into the topical treatment regimen, such as imidazoles, allylamines, and ciclopirox olamine. Systemic therapies might occasionally be used. Patient education and the promotion of good personal hygiene are pivotal to reduce the risk of recurrence. In recurrent cases, particularly during warmer and more humid periods, prolonged prophylaxis with topical agents should be considered.
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    Response to comments on the Letter to the Editor titled "Differentiating basal cell carcinoma from intradermal nevi along the eyelid margin with dermoscopy: A case series''
    (Mosby-Elsevier, 2021) Williams, Natalie M.; Navarrete Dechent, Cristian Patricio; Marghoob, Ashfaq A.; Abarzua Araya, Álvaro Rodrigo; Salerni, Gabriel; Jaimes, Natalia