Browsing by Author "Nazar, C."
Now showing 1 - 1 of 1
Results Per Page
Sort Options
- ItemEstimation of the plasma-effect-site equilibration rate constant (k(e0)) of rocuronium by the time of maximum effect: a comparison with non-parametric and parametric approaches(ELSEVIER SCI LTD, 2007) Cortinez, L. I.; Nazar, C.; Munoz, H. R.Background. The first order plasma-effect-site equilibration rate constant (k(e0)) links the pharmacokinetics (PK) and pharmacodynamics (PD) of a given drug. For the calculation of the k(e0), one method uses a single point of the response curve corresponding to the time to peak effect of a drug (t(peak)); however, it has not been validated. This study compares the k(e0) calculated with the method of tpeak and the k(e0) calculated with traditional non-parametric and parametric methods.