Browsing by Author "Nervi, Flavio"

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    A century of trends in adult human height
    (eLife Sciences Publications Ltd, 2016) Bentham, J.; Di Cesare, M.; Zhou, B.; Bixby, H.; Fortunato, L.; Bennett, J.E.; Kontis, V.; Riboli, E.; Ezzati, M.; Chan, Q.; Elliott, P.; Gunter, M.; Hihtaniemi, I. T.; Murphy, N.; Norat, T.; Ferreccio Readi, Fresia Catterina; Margozzini Maira, Paula; Miquel P., Juan Francisco; Nervi, Flavio; Valdivia Cabrera, Gonzalo
    Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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    A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
    (2007) Buch, S.; Schafmayer, C.; Völzke, H.; Becker, C.; Franke, A.; Von Eller-Eberstein, H.; Kluck, C.; Bässmann, I.; Brosch, M.; Lammert, F.; Miquel P., Juan Francisco; Nervi, Flavio; Wittig, M.; Rosskopf, D.; Timm, B.; Höll, C.; Seeger, M.; Elsharawy, A.; Lu, T.; Egberts, J.; Fändrich, F.; Fölsch, U. R.; Krawczak, M.; Schreiber, S.; Nürnberg, P.; Tepel, J.; Hampe, J.
    With an overall prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of the most frequent and economically relevant health problems of industrialized countries1,2. We performed an association scan of 4500,000 SNPs in 280 individuals with gallstones and 360 controls. A follow-up study of the 235 most significant SNPs in 1,105 affected individuals and 873 controls replicated the disease association of SNP A-1791411 in ABCG8 (allelic P value P-CCA = 4.1 x 10(-9)), which was subsequently attributed to coding variant rs11887534 (D19H). Additional replication was achieved in 728 German (P = 2.8 x 10(-7)) and 167 Chilean subjects (P = 0.02). The overall odds ratio for D19H carriership was 2.2 (95% confidence interval: 1.8-2.6, P = 1.4 x 10(-14)) in the full German sample. Association was stronger in subjects with cholesterol gallstones (odds ratio = 3.3), suggesting that His19 might be associated with a more efficient transport of cholesterol into the bile.
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    Abnormalities of lipid metabolism, gallstone disease and gallbladder function
    (2011) Zanlungo Matsuhiro, Silvana; Miquel P., Juan Francisco; Rigotti Rivera, Attilio; Nervi, Flavio
    Gallstone disease is highly prevalent with a complex and multifactorial pathogenesis. Gallstones are closely related to the metabolic syndrome associated disease conditions in which abnormal regulation of lipid metabolism secondary to insulin resistance plays a major pathogenic role. Insulin resistance increases biliary cholesterol secretion and affects gallbladder (GB) motility. Regulation of lipid metabolism and energy homeostasis is complex and the GB has been considered to have a minor regulatory role in both the intestinal absorption of lipids and metabolic homeostasis of the whole body. In fact, ablation of the GB does not affect nutrient absorption or the ability to lead a normal life. GB function regulates the cycling of bile salts through the enterohepatic circulation. Bile salts have important signaling effects that can affect whole body metabolic homeostasis. The GB and intestinal mucosa are rich in the hormone FGF15/19 and the receptor TGR5, which participate in metabolic regulation. Recent evidence supports the hypothesis that cholecystectomy may not be innocuous and that the GB has a significant role in the regulation of hepatic triglyceride metabolism. This article provides information regarding recent advances in the understanding of the interaction between regulation of lipid metabolism, insulin resistance, gallstone disease and GB function.
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    Advances in the physiological and pathological implications of cholesterol
    (2013) Cortés Mora, Víctor Antonio; Busso, Dolores; Mardones, Pablo; Maiz Gurruchaga, Manuel Alberto; Arteaga Ll., Antonio; Nervi, Flavio; Rigotti Rivera, Attilio
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    Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice
    (2011) Amigo Boker, Ludwig Peter; Quiñones, Verónica; Leiva Mendoza, Andrea Alejandra; Busso, Dolores; Zanlungo Matsuhiro, Silvana; Nervi, Flavio; Rigotti Rivera, Attilio
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    Autoevaluación sobre formación en medicina paliativa en una cohorte de residentes
    (2004) Vial C, P.; Ibañez Lazo, Patricio; Umaña Valdivia, Alfredo; Reyes Donoso, María Margarita; Viviani García, Paola; Nervi, Flavio
    Background: Little is known about the status and level of medical education on palliative care, symptom control and aspects of end of life care provided by medical school programs in Chile. Aim: To determine if a cohort of residents had palliative care and end of life care education during pre graduate and post graduate training. Residents were also asked to self assess their proficiency in these areas. Material and Methods: In 2002, we contacted 200 of a total of 327 residents of the postgraduate programs of the Pontificia Universidad Catolica de Chile. They were asked to anonymously answer a preformed questionnaire addressing different aspects related to palliative care, symptom control and end of life issues. Results: Less than 25% of residents received some degree of palliative care education during their studies, and approximately half of them considered that the level of proficiency reached was less than 25%. This contrasted with a good self assessment in the management of pain and gastrointestinal symptoms. For the treatment of the anorexia-cachexia syndrome and delirium, approximately 50% of the cohort had a mean self assessment score of 3 in a scale of 1 to 7. More than 80% of residents considered that palliative medicine education is important for their medical career. Conclusions: Chilean medical schools must improve palliative care and end of life training as part of their mandatory curriculum in both the pre and post graduate levels (Rev Méd Chile 2004; 132: 445-52).
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    Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians
    (2004) Gälman, Cecilia; Miquel P., Juan Francisco; Pérez Ayuso, Rosa María; Einarsson, Curt; Stahle, Lars; Marshall Rivera, Guillermo; Nervi, Flavio; Rudling, Mats
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    Cholecystectomy and NAFLD : does gallbladder removal have metabolic consequences?
    (2013) Nervi, Flavio; Arrese Jiménez, Marco
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    Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice
    (WILEY, 2011) Amigo, Ludwig; Husche, Constanze; Zanlungo, Silvana; Luetjohann, Dieter; Arrese, Marco; Miquel, Juan F.; Rigotti, Attilio; Nervi, Flavio
    Background & aims: Bile acid (BA) pool size remains unchanged after cholecystectomy (XGB) but it circulates faster, exposing the enterohepatic system to an increased flux of BA. Triglyceride (TG) and BA metabolisms are functionally inter-related. We investigated whether ablation of the gallbladder (GB) modifies hepatic TG metabolism. Methods: Male mice were subjected to XGB and fed a normal diet. In some experiments, mice received a 1% nicotinic acid diet to block lipolysis. Parameters of BA and TG metabolism, and microsomal triglyceride transfer protein (MTTP) activity were measured 1-2 months after XGB. Serum parameters, hepatic lipids and mRNA expression of genes of lipid metabolism were determined. Results: BA pool size and synthesis were normal, but biliary BA secretion doubled during the diurnal light phase in XGB mice. Serum and hepatic TG concentrations increased 25% (P < 0.02), and hepatic very-low-density lipoproteins (VLDL)-TG and apoB-48 productions increased 15% (P < 0.03) and 50% (P < 0.01), respectively, after XGB. Feeding a 1% nicotinic acid did normalize VLDL production. MTTP activity increased 15% (P < 0.005) after XGB. Hepatic free fatty acid (FFA) synthesis and content, and mRNA levels of lipid metabolism-related genes remained normal in XGD mice. Conclusions: XGB increased serum and hepatic TG levels, and VLDL production, which were restored to normal by nicotinic acid. The results suggest that FFA flux from adipose tissue to the liver is increased in XGB mice. They support the hypothesis that the GB has a role in the regulation of hepatic TG metabolism and that XGB may favour the accumulation of fat in the liver.
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    Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants
    (2018) Zhou, Bin; Ferreccio Readi, Catterina; Margozzini Maira, Paula; Miquel P., Juan Francisco; Nervi, Flavio; Valdivia Cabrera, Gonzalo
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    Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice
    (2010) Morales France, María Gabriela; Amigo Böker, Ludwig Peter; Balboa Castillo, Elisa Ivana; Acuña Aravena, Mariana Loreto; Castro, Juan; Molina, Héctor; Miquel P., Juan Francisco; Nervi, Flavio; Rigotti Rivera, Attilio; Zanlungo Matsuhiro, Silvana
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    Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19
    (2015) Barrera Martínez, Francisco José; Azocar, Lorena; Molina, Héctor; Schalper, Kurt A.; Ocares, Marcia; Liberona, Jessica; Villarroel del Pino, Luis A.; Pimentel Muller, Fernando; Perez Ayuso, Rosa Maria; Nervi, Flavio; Groen, Albert K.; Miquel P., Juan Francisco
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    Effect of cholecystectomy on hepatic fat accumulation and insulin resistance in non-obese Hispanic patients : a pilot study
    (2017) Cortés Mora, Víctor Antonio; Quezada Sanhueza, Nicolás; Uribe Arancibia, Sergio A.; Arrese Jiménez, Marco; Nervi, Flavio
    Abstract Background Nonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. Experimental studies have shown that cholecystectomy (XGB) increases hepatic fat content in mice and appears associated to NAFLD in large retrospective population-based studies. The aim of this study was to prospectively assess the effects of XGB on hepatic fat content (HFC) and insulin resistance (IR) in non-obese, middle aged Hispanic subjects. Methods Twenty-six gallstone patients undergoing elective XGB and 16 control subjects with normal livers and gallbladders at ultrasonography were prospectively followed 24 months for changes in HFC and IR. Clinical, biochemical determinations and hepatic imaging were performed at baseline and 24 months after surgery. MRI technique quantified HFC in four hepatic segments. IR was assessed by the Homeostasis Model Assessment (HOMA-IR) index. Results Initial body mass index (BMI) was 25.6 ± 0.4 and 24.3 ± 1.0 in the control and XGB groups of subjects, respectively. Serum insulin level increased from 8.1 ± 0.7 to 10.0 ± 1.9 (μU/ml) 24 months after surgery in XGB patients (p < 0.05); no significant changes were detected in control individuals. Median HOMA-IR index increased from 1.31 (interquartile range, 1.01-1.68) to 2.20 (interquartile range, 1.57 - 2.60) 24 months after XGB, (p < 0.003). Median HOMA-IR index of control subjects remained unchanged at the end of the study. Serum apoB concentration increased from 61.5 ± 3.4 to 79.0 ± 7.8 (μg/ml) in XGB patients (p < 0.03). Serum apoB levels remained within normal ranges in both periods of the study in control subjects. HFC significantly increased in 2 of the 4 segments 24 months after XGB: right posterior hepatic lobe (from 5.3 ± 0.2% to 6.0 ± 0.2%, p > 0.04) and right anterior hepatic lobe (from 5.8 ± 0.2% to 6.6 ± 0.3%, p < 0.02). The average HFC of the four hepatic segments studied slightly increased from 5.4 ± 0.2 to 5.8 ± 0.3 2 years after XGB (p < 0.03). No significant changes were found in HFC in the control subjects at the end of the study. Conclusions Elective XGB increases HFC, HOMA-IR index and serum apoB concentration. These results support the notion that XGB is a risk factor non-alcoholic fatty liver disease and other IR – associated disease conditions.
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    Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis : a pooled analysis of 96 population-based studies with 331288 participants
    (2015) Danaei, G.; Fahimi, S.; Lu, Y.; Zhou, B.; Hajifathalian, K.; Ferreccio Readi, Catterina; Margozzini Maira, Paula; Miquel P., Juan Francisco; Nervi, Flavio; Valdivia Cabrera, Gonzalo; Di Cesare, M.; Lo, W.; Reis, B.; Cowan, M.; Shaw, J.; Bentham, J.; Lin, J.; Bixby, H.; Magliano, D.; Bovet, P.; Danaei, G.; Fahimi, S.; Lu, Y.; Zhou, B.; Hajifathalian, K.; Ferreccio Readi, Catterina; Margozzini Maira, Paula; Miquel P., Juan Francisco; Nervi, Flavio; Valdivia Cabrera, Gonzalo; Di Cesare, M.; Lo, W.; Reis, B.; Cowan, M.; Shaw, J.; Bentham, J.; Lin, J.; Bixby, H.; Magliano, D.; Bovet, P.
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    Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331288 participants
    (2015) Danaei, Goodarz; Fahimi, Saman; Lu, Yuan; Zhou, Bin; Hajifathalian, Kaveh; Di Cesare, Mariachiara; Lo, Wei-Cheng; Reis-Santos, Barbara; Cowan, Melanie J.; Shaw, Jonathan E.; Bentham, James; Lin, John K.; Bixby, Honor; Magliano, Dianna; Bovet, Pascal; Miranda, J. Jaime; Khang, Young-Ho; Stevens, Gretchen A.; Riley, Leanne M.; Ali, Mohammed K.; Ezzati, Majid; Abdeen, Ziad A.; Kadir, Khalid Abdul; Abu-Rmeileh, Niveen M.; Acosta-Cazares, Benjamin; Aekplakorn, Wichai; Aguilar-Salinas, Carlos A.; Ahmadvand, Alireza; Al Nsour, Mohannad; Alkerwi, Ala'a; Amouyel, Philippe; Andersen, Lars Bo; Anderssen, Sigmund A.; Andrade, Dolores S.; Anjana, Ranjit Mohan; Aounallah-Skhiri, Hajer; Aris, Tahir; Arlappa, Nimmathota; Arveiler, Dominique; Assah, Felix K.; Avdicova, Maria; Balakrishna, Nagalla; Bandosz, Piotr; Barbagallo, Carlo M.; Barcelo, Alberto; Batieha, Anwar M.; Baur, Louise A.; Ben Romdhane, Habiba; Bernabe-Ortiz, Antonio; Bhargava, Santosh K.; Bi, Yufang; Bjerregaard, Peter; Bjorkelund, Cecilia; Blake, Margaret; Blokstra, Anneke; Bo, Simona; Boehm, Bernhard O.; Boissonnet, Carlos P.; Bovet, Pascal; Brajkovich, Imperia; Breckenkamp, Juergen; Brewster, Lizzy M.; Brian, Garry R.; Bruno, Graziella; Bugge, Anna; de Leon, Antonio Cabrera; Can, Gunay; Candido, Ana Paula C.; Capuano, Vincenzo; Carvalho, Maria J.; Casanueva, Felipe F.; Caserta, Carmelo A.; Castetbon, Katia; Chamukuttan, Snehalatha; Chaturvedi, Nishi; Chen, Chien-Jen; Chen, Fangfang; Chen, Shuohua; Cheng, Ching-Yu; Chetrit, Angela; Chiou, Shu-Ti; Cho, Yumi; Chudek, Jerzy; Cifkova, Renata; Claessens, Frank; Concin, Hans; Cooper, Cyrus; Cooper, Rachel; Costanzo, Simona; Cottel, Dominique; Cowell, Chris; Crujeiras, Ana B.; D'Arrigo, Graziella; Dallongeville, Jean; Dankner, Rachel; Dauchet, Luc; de Gaetano, Giovanni; De Henauw, Stefaan; Deepa, Mohan; Dehghan, Abbas; Dhana, Klodian; Di Castelnuovo, Augusto F.; Djalalinia, Shirin; Doua, Kouamelan; Drygas, Wojciech; Du, Yong; Egbagbe, Eruke E.; Eggertsen, Robert; El Ati, Jalila; Elosua, Roberto; Erasmus, Rajiv T.; Erem, Cihangir; Ergor, Gul; Eriksen, Louise; la Penaa, Jorge Escobedo-De; Fall, Caroline H.; Farzadfar, Farshad; Felix-Redondo, Francisco J.; Ferguson, Trevor S.; Fernandez-Berges, Daniel; Ferrari, Marika; Ferreccio, Catterina; Finn, Joseph D.; Foger, Bernhard; Foo, Leng Huat; Fouad, Heba M.; Francis, Damian K.; Franco, Maria do Carmo; Franco, Oscar H.; Frontera, Guillermo; Furusawa, Takuro; Gaciong, Zbigniew; Galbarczyk, Andrzej; Garnett, Sarah P.; Gaspoz, Jean-Michel; Gasull, Magda; Gates, Louise; Geleijnse, Johanna M.; Ghasemain, Anoosheh; Giampaoli, Simona; Gianfagna, Francesco; Giovannelli, Jonathan; Gross, Marcela Gonzalez; Rivas, Juan P. Gonzalez; Gorbea, Mariano Bonet; Gottrand, Frederic; Grant, Janet F.; Grodzicki, Tomasz; Grontved, Anders; Gruden, Grabriella; Gu, Dongfeng; Guan, Ong Peng; Guerrero, Ramiro; Guessous, Idris; Guimaraes, Andre L.; Gutierrez, Laura; Hardy, Rebecca; Kumar, Rachakulla Hari; He, Jiang; Heidemann, Christin; Hihtaniemi, Ilpo Tapani; Ho, Sai Yin; Ho, Suzanne C.; Hofman, Albert; Russo, Andrea R. V.; Hormiga, Claudia M.; Horta, Bernardo L.; Houti, Leila; Hussieni, Abdullatif S.; Huybrechts, Inge; Hwalla, Nahla; Iacoviello, Licia; Iannone, Anna G.; Ibrahim, Mohsen M.; Ikeda, Nayu; Ikram, M. Arfan; Irazola, Vilma E.; Islam, Muhammad; Iwasaki, Masanori; Jacobs, Jeremy M.; Jafar, Tazeen; Jasienska, Grazyna; Jiang, Chao Qiang; Jonas, Jost B.; Joshi, Pradeep; Kafatos, Anthony; Kalter-Leibovici, Ofra; Kasaeian, Amir; Katz, Joanne; Kaur, Prabhdeep; Kavousi, Maryam; Kelishadi, Roya; Kengne, Andre P.; Kersting, Mathilde; Khader, Yousef Saleh; Khang, Young-Ho; Kiechl, Stefan; Kim, Jeongseon; Kiyohara, Yutaka; Kolsteren, Patrick; Korrovits, Paul; Koskinen, Seppo; Kratzer, Wolfgang; Kromhout, Daan; Kula, Krzysztof; Kurjata, Pawel; Kyobutungi, Catherine; Lachat, Carl; Laid, Youcef; Lam, Tai Hing; Landrove, Orlando; Lanska, Vera; Lappas, Georg; Laxmaiah, Avula; Leclercq, Catherine; Lee, Jeannette; Lee, Jeonghee; Lehtimaki, Terho; Lekhraj, Rampal; Leon-Munoz, Luz M.; Li, Yanping; Lim, Wei-Yen; Lima-Costa, M. Fernanda; Lin, Hsien-Ho; Lin, Xu; Lissner, Lauren; Lorbeer, Roberto; Lozano, Jose Eugenio; Lundqvist, Annamari; Lytsy, Per; Ma, Guansheng; Machado-Coelho, George L. L.; Machi, Suka; Maggi, Stefania; Magliano, Dianna; Makdisse, Marcia; Rao, Kodavanti Mallikharjuna; Manios, Yannis; Manzato, Enzo; Margozzini, Paula; Marques-Vidal, Pedro; Martorell, Reynaldo; Masoodi, Shariq R.; Matsha, Tandi E.; Mbanya, Jean Claude N.; McFarlane, Shelly R.; McGarvey, Stephen T.; McLachlan, Stela; McNulty, Breige A.; Mediene-Benchekor, Sounnia; Meirhaeghe, Aline; Menezes, Ana Maria B.; Merat, Shahin; Meshram, Indrapal I.; Mi, Jie; Miquel, Juan Francisco; Miranda, J. Jaime; Mohamed, Mostafa K.; Mohammad, Kazem; Mohan, Viswanathan; Yusoff, Muhammad Fadhli Mohd; Moller, Niels C.; Molnar, Denes; Mondo, Charles K.; Moreno, Luis A.; Morgan, Karen; Moschonis, George; Mossakowska, Malgorzata; Mostafa, Aya; Mota, Jorge; Muiesan, Maria L.; Muller-Nurasyid, Martina; Mursu, Jaakko; Nagel, Gabriele; Namesna, Jana; Nang, Ei Ei K.; Nangia, Vinay B.; Navarrete-Munoz, Eva Maria; Ndiaye, Ndeye Coumba; Nervi, Flavio; Nguyen, Nguyen D.; Nieto-Martinez, Ramfi S. E.; Ning, Guang; Ninomiya, Toshiharu; Noale, Marianna; Noto, Davide; Ochoa-Aviles, Angelica M.; Oh, Kyungwon; Onat, Altan; Osmond, Clive; Otero, Johanna A.; Palmieri, Luigi; Panda-Jonas, Songhomitra; Panza, Francesco; Parsaeian, Mahboubeh; Peixoto, Sergio Viana; Pereira, Alexandre C.; Peters, Annette; Peykari, Niloofar; Pilav, Aida; Pitakaka, Freda; Piwonska, Aleksandra; Piwonski, Jerzy; Plans-Rubio, Pedro; Porta, Miquel; Portegies, Marileen L. P.; Poustchi, Hossein; Pradeepa, Rajendra; Price, Jacqueline F.; Punab, Margus; Qasrawi, Radwan F.; Qorbani, Mostafa; Raitakari, Olli; Rao, Sudha Ramachandra; Ramachandran, Ambady; Ramos, Rafel; Rampal, Sanjay; Rathmann, Wolfgang; Redon, Josep; Reganit, Paul Ferdinand M.; Rigo, Fernando; Robinson, Sian M.; Robitaille, Cynthia; Rodriguez, Laura A.; Rodriguez-Artalejo, Fernando; Rodriguez-Perez, Maria del Cristo; Rojas-Martinez, Rosalba; Romaguera, Dora; Rosengren, Annika; Rubinstein, Adolfo; Rui, Ornelas; Ruiz-Betancourt, Blanca Sandra; Rutkowski, Marcin; Sabanayagam, Charumathi; Sachdev, Harshpal S.; Saidi, Olfa; Sakarya, Sibel; Salanave, Benoit; Salonen, Jukka T.; Salvetti, Massimo; Sanchez-Abanto, Jose; Nunes, Renata; Santos, Rute; Sardinha, Luis B.; Scazufca, Marcia; Schargrodsky, Herman; Scheidt-Nave, Christa; Shaw, Jonathan E.; Shibuya, Kenji; Shin, Youchan; Shiri, Rahman; Siantar, Rosalynn; Sibai, Abla M.; Simon, Mary; Simons, Judith; Simons, Leon A.; Sjostrom, Michael; Slowikowska-Hilczer, Jolanta; Slusarczyk, Przemyslaw; Smeeth, Liam; Snijder, Marieke B.; Solfrizzi, Vincenzo; Sonestedt, Emily; Soumare, Aicha; Staessen, Jan A.; Steene-Johannessen, Jostein; Stehle, Peter; Stein, Aryeh D.; Stessman, Jochanan; Stockl, Doris; Stokwiszewski, Jakub; Strufaldi, Maria Wany; Sun, Chien-An; Sundstrom, Johan; Suriyawongpaisal, Paibul; Sy, Rody G.; Tai, E. Shyong; Tarawneh, Mohammed; Tarqui-Mamani, Carolina B.; Thijs, Lutgarde; Tolstrup, Janne S.; Topbas, Murat; Torrent, Maties; Traissac, Pierre; Trinh, Oanh T. H.; Tulloch-Reid, Marshall K.; Tuomainen, Tomi-Pekka; Turley, Maria L.; Tzourio, Christophe; Ueda, Peter; Ukoli, Flora M.; Ulmer, Hanno; Valdivia, Gonzalo; Van Valkengoed, Irene G. M.; Vanderschueren, Dirk; Vanuzzo, Diego; Vega, Tomas; Velasquez-Melendez, Gustavo; Veronesi, Giovanni; Verschuren, Monique; Vioque, Jesus; Virtanen, Jyrki; Visvikis-Siest, Sophie; Viswanathan, Bharathi; Vollenweider, Peter; Voutilainen, Sari; Wade, Alisha N.; Wagner, Aline; Walton, Janette; Mohamud, Wan Nazaimoon Wan; Wang, Ming-Dong; Wang, Ya Xing; Wannamethee, S. Goya; Weerasekera, Deepa; Whincup, Peter H.; Widhalm, Kurt; Wiecek, Andrzej; Wilks, Rainford J.; Willeit, Johann; Wojtyniak, Bogdan; Wong, Tien Yin; Woo, Jean; Woodward, Mark; Wu, Aleksander Giwercman; Wu, Frederick C.; Wu, Shou Ling; Xu, Haiquan; Yang, Xiaoguang; Ye, Xingwang; Yoshihara, Akihiro; Younger-Coleman, Novie O.; Zambon, Sabina; Zargar, Abdul Hamid; Zdrojewski, Tomasz; Zhao, Wenhua; Zheng, Yingfeng
    Background Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA(1c). We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in different regions.
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    Erratum: \"Insulin and cholesterol gallstones: New insights for a complex pathogenic relationship\" (Hepatology (2008) (48) (2078-2080) 10.1002/hep.22618)
    (2009) Zanlungo Matsuhiro, Silvana; Miquel P., Juan Francisco; Rigotti Rivera, Attilio; Nervi, Flavio
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    Escala numérica para evaluar síntomas espirituales en cuidados paliativos
    (2017) Bonati, P.; Nervi, Flavio; Reyes, M.; De Lima, L.; Taboada R., Paulina; Villarroel del Pino, Luis A.; Vial Correa, Juan de Dios; Blanco, O.; González, Rina; Parra, I.; Toledo, G.
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    Factores de riesgo del cáncer de la vía biliar
    (1987) Bull Simpfendorfer, Paulina; Nervi, Flavio
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    Fecal bile acid excretion and messenger RNA expression levels of ileal transporters in high risk gallstone patients
    (2009) Herrera Sepúlveda, Jorge Gabriel; Amigo Boker, Ludwig Peter; Benítez, Carlos; Zanlungo Matsuhiro, Silvana; Miquel P., Juan Francisco; Nervi, Flavio; Husche, Constanze; Lütjohann, Dieter
    Abstract Background Cholesterol gallstone disease (GS) is highly prevalent among Hispanics and American Indians. In GS, the pool of bile acids (BA) is decreased, suggesting that BA absorption is impaired. In Caucasian GS patients, mRNA levels for ileal BA transporters are decreased. We aimed to determine fecal BA excretion rates, mRNA levels for ileal BA transporter genes and of regulatory genes of BA synthesis in Hispanic GS patients. Results Excretion of fecal BA was measured in seven GS females and in ten GS-free individuals, all with a body mass index < 29. Participants ingested the stool marker Cr2O3 (300 mg/day) for 10 days, and fecal specimens were collected on the last 3 days. Chromium was measured by a colorimetric method, and BA was quantitated by gas chromatography/mass spectroscopy. Intake of calories, nutrients, fiber and cholesterol were similar in the GS and GS-free subjects. Mean BA excretion levels were 520 ± 80 mg/day for the GS-free group, and 461 ± 105 mg/day for the GS group. Messenger RNA expression levels were determined by RT-PCR on biopsy samples obtained from ileum during diagnostic colonoscopy (14 GS-free controls and 16 GS patients) and from liver during surgery performed at 8 and 10 AM (12 GS and 10 GS-free patients operated on for gastrointestinal malignancies), all with a body mass index < 29. Messenger RNA level of the BA transporter genes for ileal lipid binding protein, multidrug resistance-associated protein 3, organic solute transporter alpha, and organic solute transporter beta were similar in GS and GS-free subjects. Messenger RNA level of Cyp27A1, encoding the enzyme 27α-hydroxylase, the short heterodimer partner and farnesoid X receptor remained unchanged, whereas the mRNA level of Cyp7A1, the rate limiting step of BA synthesis, was increased more than 400% (p < 0.01) in the liver of GS compared to GS-free subjects. Conclusion Hispanics with GS have fecal BA excretion rates and mRNA levels of genes for ileal BA transporters that are similar to GS-free subjects. However, mRNA expression levels of Cyp7A1 are increased in GS, indicating that regulation of BA synthesis is abnormal in Hispanics with GS.