Browsing by Author "Opazo, Juan C."

Now showing 1 - 5 of 5
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    Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage
    (2016) Wichmann Pérez, Ignacio Alberto; Corvalán R., Alejandro; Amigo Donoso, Julio; Owen, Gareth Ivor; Zavala, Kattina.; Hoffmann, Federico G.; Vandewege, Michael W.; Opazo, Juan C.
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    Expression of RPRM/rprm in the olfactory system of embryonic zebrafish (Danio rerio)
    (2018) Stanic, Karen; Quiroz Vallverdu, Alonso Ingmar; Lemus, Carmen G.; Wichmann Pérez, Ignacio Alberto; Corvalán R., Alejandro; Owen, Gareth Ivor; Opazo, Juan C.; Concha, Miguel L.; Amigo Donoso, Julio
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    Phylogeography of the subterranean rodent Spalacopus cyanus (Caviomorpha, Octodontidae)
    (ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS, 2008) Opazo, Juan C.; Bugueno, Manuel P.; Carter, Mauricio J.; Palma, R. Eduardo; Bozinovic, Francisco
    Spalacopus cyanus is a subterranean rodent inhabiting coastal and mountain habitats. Individuals from mountain populations are larger than individuals from the coast, and mountain populations have a more limited geographic range. To investigate the genetic structure and biogeography of this species, we analyzed mitochondrial DNA control region sequences. We found low levels of nucleotide diversity in comparison with other subterranean rodents. Coastal populations had higher nucleotide diversity and effective population size than mountain populations. Phylogenetic analysis using maximum parsimony and a haplotype network generated using statistical parsimony recognized 3 groups of haplotypes: northern coastal and mountain populations, central coastal populations, and southern coastal population. Consistent with the presence of unshared haplotypes, migration rates were practically 0, except from Valparaiso to Ventanas and from La Parva to Huentelauquen. We observed asymmetric migration rates from mountain to coastal populations, suggesting that this species originated in the Andean mountains. A likelihood ration test could not reject the null hypothesis of a stable population when all sequences were grouped into a single population and when coastal populations were analyzed separately. However, a negative exponential growth parameter was estimated for mountain populations,suggesting that these populations have undergone recent demographic changes.
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    Reprimo tissue-specific expression pattern is conserved between zebrafish and human
    (2017) Figueroa, Ricardo J.; Wichmann Pérez, Ignacio Alberto; Owen, Gareth Ivor; Corvalán R., Alejandro; Amigo Donoso, Julio; Carrasco-Avino, Gonzalo.; Lange, Martin.; Siekmann, Arndt F.; Opazo, Juan C.
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    The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties
    (2018) Amigo Donoso, Julio; Wichmann Pérez, Ignacio Alberto; Jorquera Cifuentes, Roddy Alberto.; García Bloj, Benjamín.; Alarcón Alarcón, María Alejandra; Owen, Gareth Ivor; Corvalán R., Alejandro; Opazo, Juan C.