Browsing by Author "Osuna, A"

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    Characterization and trypanocidal activity of nifurtimox-containing and empty nanoparticles of polyethylcyanoacrylates
    (ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, 1998) Gonzalez Martin, G; Merino, I; Rodriguez Cabezas, MN; Torres, M; Nunez, R; Osuna, A
    The aim of this study was to evaluate the utility of nanoparticles of polyalkylcyanoacrylate as a targeted delivery system for nifurtimox against Trypanosoma cruzi, responsible for Chagas' disease. Ethylcyanoacrylate nanoparticles were prepared by an emulsion polymerization process and formulations containing different concentrations of nifurtimox, polyethylcyanoacrylates and surfactants were investigated and analysed for size and drug content.