Browsing by Author "Pérez, PM"

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    Schiff's bases formed between pyridoxal 5′-phosphate and 4-aminobutanoic acid.: Kinetic and thermodynamic study
    (2003) Gorostidi, GRE; Castellanos, MG; Pérez, PM; Santos, JG; Blanco, FG
    The overall and individual kinetic constants of formation (k(1) and k(1)(i)) and hydrolysis (k(2), k(OH) and k(2)(i)) of the Schiff's bases formed between pyridoxal 5'-phosphate (PLP) and 4-aminobutanoic acid (GABA) at 10, 20, 25, 30, and 37degreesC, a variable pH and a constant ionic strength of 0.1 M (1 M=1 mol dm(-3)) were determined. The formation of a Schiff's base is an intramolecular acid-catalyzed process. The activation and thermodynamic parameters for the formation and hydrolysis of the Schiff's bases were also determined. DeltaH and DeltaS for the individual processes were all found to be negative.