Browsing by Author "Pérez, Patricia"
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- ItemA molecular electron density theory study of the insertion of CO into frustrated Lewis pair boron-amidines : a [4+1] cycloaddition reaction(2019) Ríos Gutiérrez, Mar; Domingo, Luis R.; Rojas Guerrero, René; Toro Labbé, Alejandro; Pérez, Patricia
- ItemInfluence of SARS-CoV-2 mRNA Vaccine Booster among Cancer Patients on Active Treatment Previously Immunized with Inactivated versus mRNA Vaccines: A Prospective Cohort Study(2023) Mondaca Contreras, Sebastián Patricio; Walbaum, Benjamín; Corre, Nicole Le; Ferrés Garrido, Marcela Viviana; Valdés, Alejandro; Martínez-Valdebenito, Constanza; Ruiz-Tagle, Cinthya; Macanas Pirard, Patricia; Ross, Patricio; Cisternas, Betzabé; Pérez, Patricia; Cabrera, Olivia; Cerda, Valentina; Ormazábal, Ivana; Barrera Vásquez, Aldo Vincen; Prado, María E.; Venegas, María I.; Palma, Silvia; Broekhuizen, Richard; Kalergis, Alexis; Bueno, Susan M.; Espinoza, Manuel A.; Balcells Marty, María Elvira; Nervi Nattero, BrunoCancer patients on chemotherapy have a lower immune response to SARS-CoV-2 vaccines. Therefore, through a prospective cohort study of patients with solid tumors receiving chemotherapy, we aimed to determine the immunogenicity of an mRNA vaccine booster (BNT162b2) among patients previously immunized with an inactivated (CoronaVac) or homologous (BNT162b2) SARS-CoV-2 vaccine. The primary outcome was the proportion of patients with anti-SARS-CoV-2 neutralizing antibody (NAb) seropositivity at 8–12 weeks post-booster. The secondary end points included IgG antibody (TAb) seropositivity and specific T-cell responses. A total of 109 patients were included. Eighty-four (77%) had heterologous vaccine schedules (two doses of CoronaVac followed by the BNT162b2 booster) and twenty-five had (23%) homologous vaccine schedules (three doses of BNT162b2). IgG antibody positivity for the homologous and heterologous regimen were 100% and 96% (p = 0.338), whereas NAb positivity reached 100% and 92% (p = 0.13), respectively. Absolute NAb positivity and Tab levels were associated with the homologous schedule (with a beta coefficient of 0.26 with p = 0.027 and a geometric mean ratio 1.41 with p = 0.044, respectively). Both the homologous and heterologous vaccine regimens elicited a strong humoral and cellular response after the BNT162b2 booster. The homologous regimen was associated with higher NAb positivity and Tab levels after adjusting for relevant covariates.
- ItemReaction Electronic Flux Perspective on the Mechanism of the Zimmerman Di-π-methane Rearrangement(2018) Matute, Ricardo A.; Villegas, Nery Andrés; Herrera Pisani, Bárbara Andrea; Gutiérrez Oliva, Soledad; Toro Labbé, Alejandro; Pérez, Patricia; Chamorro, Eduardo; Cortés Arriagada, Diego
- ItemSolvent effects on electrophilicity(2001) Pérez, Patricia; Toro Labbé, Alejandro; Contreras, Renato
- ItemThe Mechanism of Double Proton Transfer in Dimers of Uracil and 2-Thiouracil-The Reaction Force Perspective(2009) Mokhtar Lamsabhi, Al; Mó, Otilia; Gutiérrez Oliva, Soledad; Pérez, Patricia; Toro Labbé, Alejandro; Yáñez, Manuel
- ItemTheoretical study of the trans-N2H2 -> cis-N2H2 and F2S2 -> FSSF reactions in gas and solution phases(2002) Chattaraj, Pratim K.; Pérez, Patricia; Zevallos Dávila, Jenny Janet; Toro Labbé, Alejandro