Browsing by Author "Paris, E"

Now showing 1 - 3 of 3
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    A suicide attempt with an oral calcium channel blocker
    (COMPARATIVE TOXICOLOGY LAB, 2000) Cavagnaro, F; Aglony, M; Rios, JC; Paris, E
    Calcium channel blockers are widely used in all-aged populations. The drugs are generally safe in therapeutic dosage, but severe side effects with elevated intake are increasingly described, mainly in adult patients. We report an adolescent girl who intentionally ingested an overdose of nifedipine.
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    Adverse drug reactions (ADRs) in hospitalized pediatric patients. A prospective study
    (DUSTRI-VERLAG DR KARL FEISTLE, 1998) Gonzalez Martin, G; Caroca, CM; Paris, E
    The aim of this study was to determine the frequency and the characteristics of ADRs in 219 hospitalized pediatric patients, using an intensive and prospective drug surveillance method. The frequency of ADRs in these patients was 13.7%. The systems most commonly affected were the gastrointestinal (32.5%), the central nervous (20.0%), and the metabolic systems (17.5%). Asparaginase, methotrexate, phenytoin, phenobarbital, erythromycin, and salbutamol were probably the drugs associated with the ADRs, According to causality, 54.2% of the ADRs were regarded as probable, and 32.2% as possible. The majority of the ADRs were moderate (51.2%), 27.9% were severe. The main treatment of the ADRs was the withdrawal of the suspected drugs. The length of the slay in the hospital and the total number of drugs given to the patients influenced significantly the frequency of ADRs. 93% of the ADRs were dose-dependent.
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    Analysis of 156 cases of plant intoxication received in the Toxicologic Information Center at Catholic University of Chile
    (COMPARATIVE TOXICOLOGY LAB, 2002) Manriquez, O; Varas, J; Rios, JC; Concha, F; Paris, E
    We present a retrospective analysis of plant and mushroom ingestions reported to the Toxicologic Information Center at the Catholic University of Chile. All the phone calls of plant and mushroom intoxications received from January 1998 through June 2000, were classified according to agent, clinical presentation, affected age group, origin of the phone call, and time from exposure to the toxic agent. OF 36,580 consultations received, 156 were intoxications with plants or mushrooms, and 53.9% of them affected children <6years. Most patients were symptomatic at consultation, with digestive, neurologic, anticholinergic or cutaneous effects. The most frequent accidental ingestions were of elephant's ear (Colocasia sp) by. children, causing digestive symptoms, and by intentional ingestions of black henbane (Hyoscyamus niger) by adolescents, causing anticholinergic symptoms 5 cases of Amanita phalloides were reported with 3 fatal due to fulminant hepatic damage. Plant and mushroom intoxications are an uncommon event, but can serious compromise those that ingest them. Despite its low incidence, public and medical community education is essential to prevent and manage these intoxications efficient.